TY - JOUR
T1 - Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.
JF - Am J Hum Genet
Y1 - 2021
A1 - Graff, Mariaelisa
A1 - Justice, Anne E
A1 - Young, Kristin L
A1 - Marouli, Eirini
A1 - Zhang, Xinruo
A1 - Fine, Rebecca S
A1 - Lim, Elise
A1 - Buchanan, Victoria
A1 - Rand, Kristin
A1 - Feitosa, Mary F
A1 - Wojczynski, Mary K
A1 - Yanek, Lisa R
A1 - Shao, Yaming
A1 - Rohde, Rebecca
A1 - Adeyemo, Adebowale A
A1 - Aldrich, Melinda C
A1 - Allison, Matthew A
A1 - Ambrosone, Christine B
A1 - Ambs, Stefan
A1 - Amos, Christopher
A1 - Arnett, Donna K
A1 - Atwood, Larry
A1 - Bandera, Elisa V
A1 - Bartz, Traci
A1 - Becker, Diane M
A1 - Berndt, Sonja I
A1 - Bernstein, Leslie
A1 - Bielak, Lawrence F
A1 - Blot, William J
A1 - Bottinger, Erwin P
A1 - Bowden, Donald W
A1 - Bradfield, Jonathan P
A1 - Brody, Jennifer A
A1 - Broeckel, Ulrich
A1 - Burke, Gregory
A1 - Cade, Brian E
A1 - Cai, Qiuyin
A1 - Caporaso, Neil
A1 - Carlson, Chris
A1 - Carpten, John
A1 - Casey, Graham
A1 - Chanock, Stephen J
A1 - Chen, Guanjie
A1 - Chen, Minhui
A1 - Chen, Yii-der I
A1 - Chen, Wei-Min
A1 - Chesi, Alessandra
A1 - Chiang, Charleston W K
A1 - Chu, Lisa
A1 - Coetzee, Gerry A
A1 - Conti, David V
A1 - Cooper, Richard S
A1 - Cushman, Mary
A1 - Demerath, Ellen
A1 - Deming, Sandra L
A1 - Dimitrov, Latchezar
A1 - Ding, Jingzhong
A1 - Diver, W Ryan
A1 - Duan, Qing
A1 - Evans, Michele K
A1 - Falusi, Adeyinka G
A1 - Faul, Jessica D
A1 - Fornage, Myriam
A1 - Fox, Caroline
A1 - Freedman, Barry I
A1 - Garcia, Melissa
A1 - Gillanders, Elizabeth M
A1 - Goodman, Phyllis
A1 - Gottesman, Omri
A1 - Grant, Struan F A
A1 - Guo, Xiuqing
A1 - Hakonarson, Hakon
A1 - Haritunians, Talin
A1 - Harris, Tamara B
A1 - Harris, Curtis C
A1 - Henderson, Brian E
A1 - Hennis, Anselm
A1 - Hernandez, Dena G
A1 - Hirschhorn, Joel N
A1 - McNeill, Lorna Haughton
A1 - Howard, Timothy D
A1 - Howard, Barbara
A1 - Hsing, Ann W
A1 - Hsu, Yu-Han H
A1 - Hu, Jennifer J
A1 - Huff, Chad D
A1 - Huo, Dezheng
A1 - Ingles, Sue A
A1 - Irvin, Marguerite R
A1 - John, Esther M
A1 - Johnson, Karen C
A1 - Jordan, Joanne M
A1 - Kabagambe, Edmond K
A1 - Kang, Sun J
A1 - Kardia, Sharon L
A1 - Keating, Brendan J
A1 - Kittles, Rick A
A1 - Klein, Eric A
A1 - Kolb, Suzanne
A1 - Kolonel, Laurence N
A1 - Kooperberg, Charles
A1 - Kuller, Lewis
A1 - Kutlar, Abdullah
A1 - Lange, Leslie
A1 - Langefeld, Carl D
A1 - Le Marchand, Loïc
A1 - Leonard, Hampton
A1 - Lettre, Guillaume
A1 - Levin, Albert M
A1 - Li, Yun
A1 - Li, Jin
A1 - Liu, Yongmei
A1 - Liu, Youfang
A1 - Liu, Simin
A1 - Lohman, Kurt
A1 - Lotay, Vaneet
A1 - Lu, Yingchang
A1 - Maixner, William
A1 - Manson, JoAnn E
A1 - McKnight, Barbara
A1 - Meng, Yan
A1 - Monda, Keri L
A1 - Monroe, Kris
A1 - Moore, Jason H
A1 - Mosley, Thomas H
A1 - Mudgal, Poorva
A1 - Murphy, Adam B
A1 - Nadukuru, Rajiv
A1 - Nalls, Mike A
A1 - Nathanson, Katherine L
A1 - Nayak, Uma
A1 - N'diaye, Amidou
A1 - Nemesure, Barbara
A1 - Neslund-Dudas, Christine
A1 - Neuhouser, Marian L
A1 - Nyante, Sarah
A1 - Ochs-Balcom, Heather
A1 - Ogundiran, Temidayo O
A1 - Ogunniyi, Adesola
A1 - Ojengbede, Oladosu
A1 - Okut, Hayrettin
A1 - Olopade, Olufunmilayo I
A1 - Olshan, Andrew
A1 - Padhukasahasram, Badri
A1 - Palmer, Julie
A1 - Palmer, Cameron D
A1 - Palmer, Nicholette D
A1 - Papanicolaou, George
A1 - Patel, Sanjay R
A1 - Pettaway, Curtis A
A1 - Peyser, Patricia A
A1 - Press, Michael F
A1 - Rao, D C
A1 - Rasmussen-Torvik, Laura J
A1 - Redline, Susan
A1 - Reiner, Alex P
A1 - Rhie, Suhn K
A1 - Rodriguez-Gil, Jorge L
A1 - Rotimi, Charles N
A1 - Rotter, Jerome I
A1 - Ruiz-Narvaez, Edward A
A1 - Rybicki, Benjamin A
A1 - Salako, Babatunde
A1 - Sale, Michèle M
A1 - Sanderson, Maureen
A1 - Schadt, Eric
A1 - Schreiner, Pamela J
A1 - Schurmann, Claudia
A1 - Schwartz, Ann G
A1 - Shriner, Daniel A
A1 - Signorello, Lisa B
A1 - Singleton, Andrew B
A1 - Siscovick, David S
A1 - Smith, Jennifer A
A1 - Smith, Shad
A1 - Speliotes, Elizabeth
A1 - Spitz, Margaret
A1 - Stanford, Janet L
A1 - Stevens, Victoria L
A1 - Stram, Alex
A1 - Strom, Sara S
A1 - Sucheston, Lara
A1 - Sun, Yan V
A1 - Tajuddin, Salman M
A1 - Taylor, Herman
A1 - Taylor, Kira
A1 - Tayo, Bamidele O
A1 - Thun, Michael J
A1 - Tucker, Margaret A
A1 - Vaidya, Dhananjay
A1 - Van Den Berg, David J
A1 - Vedantam, Sailaja
A1 - Vitolins, Mara
A1 - Wang, Zhaoming
A1 - Ware, Erin B
A1 - Wassertheil-Smoller, Sylvia
A1 - Weir, David R
A1 - Wiencke, John K
A1 - Williams, Scott M
A1 - Williams, L Keoki
A1 - Wilson, James G
A1 - Witte, John S
A1 - Wrensch, Margaret
A1 - Wu, Xifeng
A1 - Yao, Jie
A1 - Zakai, Neil
A1 - Zanetti, Krista
A1 - Zemel, Babette S
A1 - Zhao, Wei
A1 - Zhao, Jing Hua
A1 - Zheng, Wei
A1 - Zhi, Degui
A1 - Zhou, Jie
A1 - Zhu, Xiaofeng
A1 - Ziegler, Regina G
A1 - Zmuda, Joe
A1 - Zonderman, Alan B
A1 - Psaty, Bruce M
A1 - Borecki, Ingrid B
A1 - Cupples, L Adrienne
A1 - Liu, Ching-Ti
A1 - Haiman, Christopher A
A1 - Loos, Ruth
A1 - Ng, Maggie C Y
A1 - North, Kari E
AB - Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) < 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p < 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained ≤20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations.

VL - 108
IS - 4
ER -