TY - JOUR T1 - Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. JF - Nat Commun Y1 - 2021 A1 - Harris, William S A1 - Tintle, Nathan L A1 - Imamura, Fumiaki A1 - Qian, Frank A1 - Korat, Andres V Ardisson A1 - Marklund, Matti A1 - Djoussé, Luc A1 - Bassett, Julie K A1 - Carmichael, Pierre-Hugues A1 - Chen, Yun-Yu A1 - Hirakawa, Yoichiro A1 - Küpers, Leanne K A1 - Laguzzi, Federica A1 - Lankinen, Maria A1 - Murphy, Rachel A A1 - Samieri, Cecilia A1 - Senn, Mackenzie K A1 - Shi, Peilin A1 - Virtanen, Jyrki K A1 - Brouwer, Ingeborg A A1 - Chien, Kuo-Liong A1 - Eiriksdottir, Gudny A1 - Forouhi, Nita G A1 - Geleijnse, Johanna M A1 - Giles, Graham G A1 - Gudnason, Vilmundur A1 - Helmer, Catherine A1 - Hodge, Allison A1 - Jackson, Rebecca A1 - Khaw, Kay-Tee A1 - Laakso, Markku A1 - Lai, Heidi A1 - Laurin, Danielle A1 - Leander, Karin A1 - Lindsay, Joan A1 - Micha, Renata A1 - Mursu, Jaako A1 - Ninomiya, Toshiharu A1 - Post, Wendy A1 - Psaty, Bruce M A1 - Riserus, Ulf A1 - Robinson, Jennifer G A1 - Shadyab, Aladdin H A1 - Snetselaar, Linda A1 - Sala-Vila, Aleix A1 - Sun, Yangbo A1 - Steffen, Lyn M A1 - Tsai, Michael Y A1 - Wareham, Nicholas J A1 - Wood, Alexis C A1 - Wu, Jason H Y A1 - Hu, Frank A1 - Sun, Qi A1 - Siscovick, David S A1 - Lemaitre, Rozenn N A1 - Mozaffarian, Dariush KW - Aged KW - Aged, 80 and over KW - Cause of Death KW - Fatty Acids, Omega-3 KW - Female KW - Follow-Up Studies KW - Humans KW - Male KW - Middle Aged KW - Mortality, Premature KW - Prospective Studies KW - Protective Factors KW - Risk Factors AB -

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

VL - 12 IS - 1 ER -