TY - JOUR T1 - Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults. JF - J Thromb Haemost Y1 - 2006 A1 - Jenny, N S A1 - Arnold, A M A1 - Kuller, L H A1 - Sharrett, A R A1 - Fried, L P A1 - Psaty, B M A1 - Tracy, R P KW - Aged KW - Aged, 80 and over KW - Angina Pectoris KW - Biomarkers KW - Cardiovascular Diseases KW - Female KW - Humans KW - Incidence KW - Intercellular Adhesion Molecule-1 KW - Male KW - Mortality KW - Myocardial Infarction KW - Regression Analysis KW - Risk Factors KW - Sex Factors KW - Solubility KW - Stroke AB -

BACKGROUND: Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.

OBJECTIVES: We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.

METHODS: Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.

RESULTS: sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.

CONCLUSIONS: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.

VL - 4 IS - 1 U1 - https://www.ncbi.nlm.nih.gov/pubmed/16409459?dopt=Abstract ER -