TY - JOUR T1 - The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study. JF - J Am Coll Cardiol Y1 - 2006 A1 - Bryson, Chris L A1 - Mukamal, Kenneth J A1 - Mittleman, Murray A A1 - Fried, Linda P A1 - Hirsch, Calvin H A1 - Kitzman, Dalane W A1 - Siscovick, David S KW - Aged KW - Alcohol Drinking KW - Chi-Square Distribution KW - Comorbidity KW - Female KW - Heart Failure KW - Humans KW - Life Style KW - Male KW - Multicenter Studies as Topic KW - Myocardial Infarction KW - Proportional Hazards Models KW - Risk Factors KW - Smoking AB -

OBJECTIVES: We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI).

BACKGROUND: Moderate alcohol consumption has been associated with lower risk of CHF and MI.

METHODS: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects > or =65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption.

RESULTS: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week (hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.67 to 1.00, p = 0.05) and 7 to 13 drinks per week (HR 0.66, 95% CI 0.47 to 0.91, p = 0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF (for 1 to 6 drinks per week, HR 0.84, 95% CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95% CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers (HR 1.51, p < 0.01), but those who quit during the study did not have a higher risk (HR 0.83, 95% CI 0.66 to 1.03).

CONCLUSIONS: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.

VL - 48 IS - 2 U1 - https://www.ncbi.nlm.nih.gov/pubmed/16843180?dopt=Abstract ER -