TY - JOUR T1 - Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults. JF - Am J Clin Nutr Y1 - 2007 A1 - Mukamal, Kenneth J A1 - Jenny, Nancy S A1 - Tracy, Russell P A1 - Siscovick, David S KW - Aged KW - Alcohol Drinking KW - Apolipoprotein E4 KW - Apolipoproteins E KW - Blood Glucose KW - C-Reactive Protein KW - Cohort Studies KW - Female KW - Genotype KW - Humans KW - Interleukin-6 KW - Male KW - Promoter Regions, Genetic KW - Serum Amyloid P-Component AB -

BACKGROUND: Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain.

OBJECTIVE: We determined how alcohol intake and apolipoprotein E (apo E) and IL-6 promoter (IL-6 -174G-->C) polymorphisms interact for concentrations of IL-6 and SAP.

DESIGN: In the Cardiovascular Health Study, 2454 older adults reported their intake of beer, wine, and liquor and underwent measurements of circulating IL-6 and SAP.

RESULTS: Alcohol intake was not associated with IL-6 concentrations among apo E4-negative or IL-6C-positive participants but was positively associated among both apo E4-positive and IL-6C-negative participants (P for trend = 0.02 for both). The corresponding interactions on SAP were not significant for alcohol overall but were similar for liquor intake.

CONCLUSIONS: Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Genetic heterogeneity should be considered in understanding the cardiovascular effects of alcohol intake.

VL - 86 IS - 2 U1 - https://www.ncbi.nlm.nih.gov/pubmed/17684217?dopt=Abstract ER -