TY - JOUR T1 - Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. JF - Am J Hum Genet Y1 - 2008 A1 - Reiner, Alexander P A1 - Barber, Mathew J A1 - Guan, Yongtao A1 - Ridker, Paul M A1 - Lange, Leslie A A1 - Chasman, Daniel I A1 - Walston, Jeremy D A1 - Cooper, Gregory M A1 - Jenny, Nancy S A1 - Rieder, Mark J A1 - Durda, J Peter A1 - Smith, Joshua D A1 - Novembre, John A1 - Tracy, Russell P A1 - Rotter, Jerome I A1 - Stephens, Matthew A1 - Nickerson, Deborah A A1 - Krauss, Ronald M KW - Aged KW - Bayes Theorem KW - C-Reactive Protein KW - Female KW - Hepatocyte Nuclear Factor 1-alpha KW - Humans KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Male KW - Middle Aged KW - Polymorphism, Single Nucleotide KW - Pravastatin KW - Simvastatin AB -

Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.

VL - 82 IS - 5 U1 - https://www.ncbi.nlm.nih.gov/pubmed/18439552?dopt=Abstract ER -