TY - JOUR T1 - Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. JF - Nat Genet Y1 - 2010 A1 - Hancock, Dana B A1 - Eijgelsheim, Mark A1 - Wilk, Jemma B A1 - Gharib, Sina A A1 - Loehr, Laura R A1 - Marciante, Kristin D A1 - Franceschini, Nora A1 - van Durme, Yannick M T A A1 - Chen, Ting-Hsu A1 - Barr, R Graham A1 - Schabath, Matthew B A1 - Couper, David J A1 - Brusselle, Guy G A1 - Psaty, Bruce M A1 - van Duijn, Cornelia M A1 - Rotter, Jerome I A1 - Uitterlinden, André G A1 - Hofman, Albert A1 - Punjabi, Naresh M A1 - Rivadeneira, Fernando A1 - Morrison, Alanna C A1 - Enright, Paul L A1 - North, Kari E A1 - Heckbert, Susan R A1 - Lumley, Thomas A1 - Stricker, Bruno H C A1 - O'Connor, George T A1 - London, Stephanie J KW - Databases, Genetic KW - Female KW - Forced Expiratory Volume KW - Genetic Predisposition to Disease KW - Genome, Human KW - Genome-Wide Association Study KW - Humans KW - Lung KW - Lung Diseases KW - Male KW - Meta-Analysis as Topic KW - Polymorphism, Single Nucleotide KW - Spirometry KW - Vital Capacity AB -

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

VL - 42 IS - 1 U1 - http://www.ncbi.nlm.nih.gov/pubmed/20010835?dopt=Abstract ER -