TY - JOUR T1 - Dietary protein intake and change in estimated GFR in the Cardiovascular Health Study. JF - Nutrition Y1 - 2014 A1 - Beasley, Jeannette M A1 - Katz, Ronit A1 - Shlipak, Michael A1 - Rifkin, Dena E A1 - Siscovick, David A1 - Kaplan, Robert KW - Aged KW - Aging KW - Diet KW - Dietary Proteins KW - Feeding Behavior KW - Female KW - Glomerular Filtration Rate KW - Health KW - Humans KW - Kidney KW - Male KW - Regression Analysis KW - Surveys and Questionnaires AB -

OBJECTIVE: With aging, kidney function declines, as evidenced by reduced glomerular filtration rate. It is controversial whether or not high protein intake accelerates this decline. The aim of this study was to determine whether high protein intake was associated with declines in kidney function among older patients.

METHODS: We examined whether dietary protein is associated with change in kidney function (mean follow-up 6.4 y [SD = 1.4, range = 2.5-7.9] in the Cardiovascular Health Study (N = 3623). We estimated protein intake using a food frequency questionnaire and estimated glomerular filtration rate from cystatin C. Associations between protein intake and kidney function were determined by linear and logistic regression models.

RESULTS: Average protein intake was 19% of energy intake (SD = 5%). Twenty-seven percent (n = 963) of study participants had rapid decline in kidney function, as defined by (ΔeGFRcysC > 3 mL•min•1.73 m(2)). Protein intake (characterized as g/d and % energy/d), was not associated with change in estimated glomerular filtration rate (P > 0.05 for all comparisons). There were also no significant associations when protein intake was separated by source (animal and vegetable).

CONCLUSION: These data suggest that higher protein intake does not have a major effect on kidney function decline among elderly men and women.

VL - 30 IS - 7-8 U1 - http://www.ncbi.nlm.nih.gov/pubmed/24984995?dopt=Abstract ER -