Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA, Kuller LH, Manolio TA, Mittelmark MB, Newman A. The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991  ;1(3):263-76.

Psaty BM, Lee M, Savage PJ, Rutan GH, German PS, Lyles M. Assessing the use of medications in the elderly: methods and initial experience in the Cardiovascular Health Study. The Cardiovascular Health Study Collaborative Research Group. J Clin Epidemiol. 1992  ;45(6):683-92.

O'Leary DH, Polak JF, Kronmal RA, Kittner SJ, Bond MG, Wolfson SK, Bommer W, Price TR, Gardin JM, Savage PJ. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke. 1992  ;23(12):1752-60.

Gardin JM, Wong ND, Bommer W, Klopfenstein HS, Smith VE, Tabatznik B, Siscovick D, Lobodzinski S, Anton-Culver H, Manolio TA. Echocardiographic design of a multicenter investigation of free-living elderly subjects: the Cardiovascular Health Study. J Am Soc Echocardiogr. 1992  ;5(1):63-72.

Manolio TA, Furberg CD, Wahl PW, Tracy RP, Borhani NO, Gardin JM, Fried LP, O'Leary DH, Kuller LH. Eligibility for cholesterol referral in community-dwelling older adults. The Cardiovascular Health Study. Ann Intern Med. 1992  ;116(8):641-9.

Price TR, Psaty B, O'Leary D, Burke G, Gardin J. Assessment of cerebrovascular disease in the Cardiovascular Health Study. Ann Epidemiol. 1993  ;3(5):504-7.

Mittelmark MB, Psaty BM, Rautaharju PM, Fried LP, Borhani NO, Tracy RP, Gardin JM, O'Leary DH. Prevalence of cardiovascular diseases among older adults. The Cardiovascular Health Study. Am J Epidemiol. 1993  ;137(3):311-7.

Polak JF, O'Leary DH, Kronmal RA, Wolfson SK, Bond MG, Tracy RP, Gardin JM, Kittner SJ, Price TR, Savage PJ. Sonographic evaluation of carotid artery atherosclerosis in the elderly: relationship of disease severity to stroke and transient ischemic attack. Radiology. 1993  ;188(2):363-70.

Psaty BM, Savage PJ, Tell GS, Polak JF, Hirsch CH, Gardin JM, McDonald RH. Temporal patterns of antihypertensive medication use among elderly patients. The Cardiovascular Health Study. JAMA. 1993  ;270(15):1837-41.

Manolio TA, Furberg CD, Rautaharju PM, Siscovick D, Newman AB, Borhani NO, Gardin JM, Tabatznik B. Cardiac arrhythmias on 24-h ambulatory electrocardiography in older women and men: the Cardiovascular Health Study. J Am Coll Cardiol. 1994  ;23(4):916-25.

Manolio TA, Kronmal RA, Burke GL, Poirier V, O'Leary DH, Gardin JM, Fried LP, Steinberg EP, Bryan RN. Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke. 1994  ;25(2):318-27.

Fried LP, Ettinger WH, Lind B, Newman AB, Gardin J. Physical disability in older adults: a physiological approach. Cardiovascular Health Study Research Group. J Clin Epidemiol. 1994  ;47(7):747-60.

Schulz R, Mittelmark M, Kronmal R, Polak JF, Hirsch CH, German P, Bookwala J. Predictors of perceived health status in elderly men and women. The Cardiovascular Health Study. J Aging Health. 1994  ;6(4):419-47.

Furberg CD, Psaty BM, Manolio TA, Gardin JM, Smith VE, Rautaharju PM. Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am J Cardiol. 1994  ;74(3):236-41.

Kuller L, Borhani N, Furberg C, Gardin J, Manolio T, O'Leary D, Psaty B, Robbins J. Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study. Am J Epidemiol. 1994  ;139(12):1164-79.

Rautaharju PM, Manolio TA, Furberg CD, Siscovick D, Newman AB, Borhani NO, Gardin JM. Ischemic episodes in 24-h ambulatory electrocardiograms of elderly persons: the Cardiovascular Health Study. Int J Cardiol. 1995  ;51(2):165-75.

Enright PL, Kronmal RA, Smith VE, Gardin JM, Schenker MB, Manolio TA. Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy. The Cardiovascular Health Study. Chest. 1995  ;107(1):28-35.

Gardin JM, Siscovick D, Anton-Culver H, Lynch JC, Smith VE, Klopfenstein HS, Bommer WJ, Fried L, O'Leary D, Manolio TA. Sex, age, and disease affect echocardiographic left ventricular mass and systolic function in the free-living elderly. The Cardiovascular Health Study. Circulation. 1995  ;91(6):1739-48.

Kuller LH, Shemanski L, Psaty BM, Borhani NO, Gardin J, Haan MN, O'Leary DH, Savage PJ, Tell GS, Tracy R. Subclinical disease as an independent risk factor for cardiovascular disease. Circulation. 1995  ;92(4):720-6.

Psaty BM, Koepsell TD, Yanez ND, Smith NL, Manolio TA, Heckbert SR, Borhani NO, Gardin JM, Gottdiener JS, Rutan GH. Temporal patterns of antihypertensive medication use among older adults, 1989 through 1992. An effect of the major clinical trials on clinical practice?. JAMA. 1995  ;273(18):1436-8.

Kronmal RA, Smith VE, O'Leary DH, Polak JF, Gardin JM, Manolio TA. Carotid artery measures are strongly associated with left ventricular mass in older adults (a report from the Cardiovascular Health Study). Am J Cardiol. 1996  ;77(8):628-33.

Rautaharju PM, Manolio TA, Siscovick D, Zhou SH, Gardin JM, Furberg CD, Borhani NO, Newman AB. Classification accuracy of electrocardiographic criteria for left ventricular hypertrophy in normal weight and overweight older adults: the Cardiovascular Health Study. Annals of Noninvasive Electrocardiology. 1996  ;1(2):132.

Polak JF, Kronmal RA, Tell GS, O'Leary DH, Savage PJ, Gardin JM, Rutan GH, Borhani NO. Compensatory increase in common carotid artery diameter. Relation to blood pressure and artery intima-media thickness in older adults. Cardiovascular Health Study. Stroke. 1996  ;27(11):2012-5.

O'Leary DH, Polak JF, Kronmal RA, Savage PJ, Borhani NO, Kittner SJ, Tracy R, Gardin JM, Price TR, Furberg CD. Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke. 1996  ;27(2):224-31.

Rautaharju PM, Manolio TA, Siscovick D, Zhou SH, Gardin JM, Kronmal R, Furberg CD, Borhani NO, Newman A. Utility of new electrocardiographic models for left ventricular mass in older adults. The Cardiovascular Health Study Collaborative Research Group. Hypertension. 1996  ;28(1):8-15.

Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol. 1997  ;29(3):630-4.

Lee M, Gardin JM, Lynch JC, Smith VE, Tracy RP, Savage PJ, Szklo M, Ward BJ. Diabetes mellitus and echocardiographic left ventricular function in free-living elderly men and women: The Cardiovascular Health Study. Am Heart J. 1997  ;133(1):36-43.

Duncan PW, Samsa GP, Weinberger M, Goldstein LB, Bonito A, Witter DM, Enarson C, Matchar D. Health status of individuals with mild stroke. Stroke. 1997  ;28(4):740-5.

Samsa GP, Cohen SJ, Goldstein LB, Bonito AJ, Duncan PW, Enarson C, DeFriese GH, Horner RD, Matchar DB. Knowledge of risk among patients at increased risk for stroke. Stroke. 1997  ;28(5):916-21.

Gardin JM, Arnold A, Gottdiener JS, Wong ND, Fried LP, Klopfenstein HS, O'Leary DH, Tracy R, Kronmal R. Left ventricular mass in the elderly. The Cardiovascular Health Study. Hypertension. 1997  ;29(5):1095-103.

Burton LC, Newsom JT, Schulz R, Hirsch CH, German PS. Preventive health behaviors among spousal caregivers. Prev Med. 1997  ;26(2):162-9.

Letovsky SI, Whitehead SH, Paik CH, Miller GA, Gerber J, Herskovits EH, Fulton TK, Bryan RN. A brain image database for structure/function analysis. AJNR Am J Neuroradiol. 1998  ;19(10):1869-77.

Gleason PP, Schulz R, Smith NL, Newsom JT, Kroboth PD, Kroboth FJ, Psaty BM. Correlates and prevalence of benzodiazepine use in community-dwelling elderly. J Gen Intern Med. 1998  ;13(4):243-50.

Robbins JA, Yanez D, Powe NR, Savage PJ, Ives DG, Gardin JM, Lyles M. Factors Associated With Hospital Utilization in the Elderly: From the Cardiovascular Health Study. Am J Geriatr Cardiol. 1998  ;7(3):27-35.

Visser M, Langlois J, Guralnik JM, Cauley JA, Kronmal RA, Robbins J, Williamson JD, Harris TB. High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr. 1998  ;68(3):584-90.

Gardin JM, Arnold AM, Bild DE, Smith VE, Lima JA, Klopfenstein HS, Kitzman DW. Left ventricular diastolic filling in the elderly: the cardiovascular health study. Am J Cardiol. 1998  ;82(3):345-51.

Redline S, Sanders MH, Lind BK, Quan SF, Iber C, Gottlieb DJ, Bonekat WH, Rapoport DM, Smith PL, Kiley JP. Methods for obtaining and analyzing unattended polysomnography data for a multicenter study. Sleep Heart Health Research Group. Sleep. 1998  ;21(7):759-67.

Whitney CW, Gottlieb DJ, Redline S, Norman RG, Dodge RR, Shahar E, Surovec S, Nieto FJ. Reliability of scoring respiratory disturbance indices and sleep staging. Sleep. 1998  ;21(7):749-57.

Fried LP, Kronmal RA, Newman AB, Bild DE, Mittelmark MB, Polak JF, Robbins JA, Gardin JM. Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA. 1998  ;279(8):585-92.

Smith NL, Psaty BM, Pitt B, Garg R, Gottdiener JS, Heckbert SR. Temporal patterns in the medical treatment of congestive heart failure with angiotensin-converting enzyme inhibitors in older adults, 1989 through 1995. Arch Intern Med. 1998  ;158(10):1074-80.

Lemaitre RN, Furberg CD, Newman AB, Hulley SB, Gordon DJ, Gottdiener JS, McDonald RH, Psaty BM. Time trends in the use of cholesterol-lowering agents in older adults: the Cardiovascular Health Study. Arch Intern Med. 1998  ;158(16):1761-8.

Samsa GP, Matchar DB, Goldstein L, Bonito A, Duncan PW, Lipscomb J, Enarson C, Witter D, Venus P, Paul JE, et al. Utilities for major stroke: results from a survey of preferences among persons at increased risk for stroke. Am Heart J. 1998  ;136(4 Pt 1):703-13.

Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999  ;341(3):142-7.

White RH, McBurnie MA, Manolio T, Furberg CD, Gardin JM, Kittner SJ, Bovill E, Knepper L. Oral anticoagulation in patients with atrial fibrillation: adherence with guidelines in an elderly cohort. Am J Med. 1999  ;106(2):165-71.

Gottlieb DJ, Whitney CW, Bonekat WH, Iber C, James GD, Lebowitz M, Nieto FJ, Rosenberg CE. Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am J Respir Crit Care Med. 1999  ;159(2):502-7.

Psaty BM, Furberg CD, Kuller LH, Bild DE, Rautaharju PM, Polak JF, Bovill E, Gottdiener JS. Traditional risk factors and subclinical disease measures as predictors of first myocardial infarction in older adults: the Cardiovascular Health Study. Arch Intern Med. 1999  ;159(12):1339-47.

Enright PL, McClelland RL, Newman AB, Gottlieb DJ, Lebowitz MD. Underdiagnosis and undertreatment of asthma in the elderly. Cardiovascular Health Study Research Group. Chest. 1999  ;116(3):603-13.

Siscovick DS, Schwartz SM, Corey L, Grayston JT, Ashley R, Wang SP, Psaty BM, Tracy RP, Kuller LH, Kronmal RA. Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study. Circulation. 2000  ;102(19):2335-40.

Newman AB, Naydeck B, Sutton-Tyrrell K, Edmundowicz D, Gottdiener J, Kuller LH. Coronary artery calcification in older adults with minimal clinical or subclinical cardiovascular disease. J Am Geriatr Soc. 2000  ;48(3):256-63.

Gottlieb DJ, Yao Q, Redline S, Ali T, Mahowald MW. Does snoring predict sleepiness independently of apnea and hypopnea frequency?. Am J Respir Crit Care Med. 2000  ;162(4 Pt 1):1512-7.

Redline S, Kapur VK, Sanders MH, Quan SF, Gottlieb DJ, Rapoport DM, Bonekat WH, Smith PL, Kiley JP, Iber C. Effects of varying approaches for identifying respiratory disturbances on sleep apnea assessment. Am J Respir Crit Care Med. 2000  ;161(2 Pt 1):369-74.

Gottdiener JS, Yanez D, Rautaharju, ii P, Gardin JM, Bild DE, Lima J, Newman AB. Orthostatic Hypotension in the Elderly: Contributions of Impaired LV Filling and Altered Sympathovagal Balance. Am J Geriatr Cardiol. 2000  ;9(5):273-280.

Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW, Gardin JM, Rutledge JE, Boineau RC. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol. 2000  ;35(6):1628-37.

Sheifer SE, Gersh BJ, Yanez ND, Ades PA, Burke GL, Manolio TA. Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly. J Am Coll Cardiol. 2000  ;35(1):119-26.

Rautaharju PM, Park LP, Gottdiener JS, Siscovick D, Boineau R, Smith V, Powe NR. Race- and sex-specific ECG models for left ventricular mass in older populations. Factors influencing overestimation of left ventricular hypertrophy prevalence by ECG criteria in African-Americans. J Electrocardiol. 2000  ;33(3):205-18.

Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol. 2001  ;153(3):242-50.

Baldwin CM, Griffith KA, Nieto FJ, O'Connor GT, Walsleben JA, Redline S. The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study. Sleep. 2001  ;24(1):96-105.

Newman AB, Gottdiener JS, McBurnie MA, Hirsch CH, Kop WJ, Tracy R, Walston JD, Fried LP. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci. 2001  ;56(3):M158-66.

Guidry UC, Mendes LA, Evans JC, Levy D, O'Connor GT, Larson MG, Gottlieb DJ, Benjamin EJ. Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart Study. Am J Respir Crit Care Med. 2001  ;164(6):933-8.

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001  ;56(3):M146-56.

Kitzman DW, Gardin JM, Gottdiener JS, Arnold A, Boineau R, Aurigemma G, Marino EK, Lyles M, Cushman M, Enright PL. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study. Am J Cardiol. 2001  ;87(4):413-9.

Gardin JM, McClelland R, Kitzman D, Lima JA, Bommer W, Klopfenstein HS, Wong ND, Smith VE, Gottdiener J. M-mode echocardiographic predictors of six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study). Am J Cardiol. 2001  ;87(9):1051-7.

Aurigemma GP, Gottdiener JS, Shemanski L, Gardin J, Kitzman D. Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol. 2001  ;37(4):1042-8.

Griffith KA, Sherrill DL, Siegel EM, Manolio TA, Bonekat HW, Enright PL. Predictors of loss of lung function in the elderly: the Cardiovascular Health Study. Am J Respir Crit Care Med. 2001  ;163(1):61-8.

Barzilay JI, Spiekerman CF, Kuller LH, Burke GL, Bittner V, Gottdiener JS, Brancati FL, Orchard TJ, O'Leary DH, Savage PJ. Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders: the Cardiovascular Health Study. Diabetes Care. 2001  ;24(7):1233-9.

de Simone G, McClelland R, Gottdiener JS, Celentano A, Kronmal RA, Gardin JM. Relation of hemodynamics and risk factors to ventricular-vascular interactions in the elderly: the Cardiovascular Health Study. J Hypertens. 2001  ;19(10):1893-903.

Newman AB, Nieto FJ, Guidry U, Lind BK, Redline S, Pickering TG, Quan SF. Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am J Epidemiol. 2001  ;154(1):50-9.

Rautaharju PM, Nelson JC, Kronmal RA, Zhang ZM, Robbins J, Gottdiener JS, Furberg CD, Manolio T, Fried L. Usefulness of T-axis deviation as an independent risk indicator for incident cardiac events in older men and women free from coronary heart disease (the Cardiovascular Health Study). Am J Cardiol. 2001  ;88(2):118-23.

Walston J, McBurnie MAnn, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002  ;162(20):2333-41.

Kop WJ, Gottdiener JS, Tangen CM, Fried LP, McBurnie MAnn, Walston J, Newman A, Hirsch C, Tracy RP. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol. 2002  ;89(4):419-24.

Manolio TA, Gottdiener JS, Tsang TSM, Gardin JM. Left atrial dimensions determined by M-mode echocardiography in black and white older (> or =65 years) adults (The Cardiovascular Health Study). Am J Cardiol. 2002  ;90(9):983-7.

Gottdiener JS, McClelland RL, Marshall R, Shemanski L, Furberg CD, Kitzman DW, Cushman M, Polak J, Gardin JM, Gersh BJ, et al. Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study. Ann Intern Med. 2002  ;137(8):631-9.

Young T, Shahar E, F Nieto J, Redline S, Newman AB, Gottlieb DJ, Walsleben JA, Finn L, Enright P, Samet JM. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002  ;162(8):893-900.

Klein R, Marino EK, Kuller LH, Polak JF, Tracy RP, Gottdiener JS, Burke GL, Hubbard LD, Boineau R. The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study. Br J Ophthalmol. 2002  ;86(1):84-90.

Crum RM, Puddey I, Gilbert CG, Fried LP. Reproducibility of two approaches for assessing alcohol consumption among older adults. Addiction Research and Theory. 2002  ;10(4):385.

Green DM, Ropper AH, Kronmal RA, Psaty BM, Burke GL. Serum potassium level and dietary potassium intake as risk factors for stroke. Neurology. 2002  ;59(3):314-20.

Quan SF, Griswold ME, Iber C, F Nieto J, Rapoport DM, Redline S, Sanders M, Young T. Short-term variability of respiration and sleep during unattended nonlaboratory polysomnography--the Sleep Heart Health Study. [corrected]. Sleep. 2002  ;25(8):843-9.

Lumley T, Kronmal RA, Cushman M, Manolio TA, Goldstein S. A stroke prediction score in the elderly: validation and Web-based application. J Clin Epidemiol. 2002  ;55(2):129-36.

Psaty BM, Manolio TA, Smith NL, Heckbert SR, Gottdiener JS, Burke GL, Weissfeld J, Enright P, Lumley T, Powe N, et al. Time trends in high blood pressure control and the use of antihypertensive medications in older adults: the Cardiovascular Health Study. Arch Intern Med. 2002  ;162(20):2325-32.

Robbins J, Nelson JClark, Rautaharju PM, Gottdiener JS. The association between the length of the QT interval and mortality in the Cardiovascular Health Study. Am J Med. 2003  ;115(9):689-94.

Resnick HE, Redline S, Shahar E, Gilpin A, Newman A, Walter R, Ewy GA, Howard BV, Punjabi NM. Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care. 2003  ;26(3):702-9.

Wong TYin, Klein R, A Sharrett R, Manolio TA, Hubbard LD, Marino EK, Kuller L, Burke G, Tracy RP, Polak JF, et al. The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study. Ophthalmology. 2003  ;110(4):658-66.

Lind BK, Goodwin JL, Hill JG, Ali T, Redline S, Quan SF. Recruitment of healthy adults into a study of overnight sleep monitoring in the home: experience of the Sleep Heart Health Study. Sleep Breath. 2003  ;7(1):13-24.

Fried LF, Shlipak MG, Crump C, Bleyer AJ, Gottdiener JS, Kronmal RA, Kuller LH, Newman AB. Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals. J Am Coll Cardiol. 2003  ;41(8):1364-72.

Newman AB, Arnold AM, Naydeck BL, Fried LP, Burke GL, Enright P, Gottdiener J, Hirsch C, O'Leary D, Tracy R. "Successful aging": effect of subclinical cardiovascular disease. Arch Intern Med. 2003  ;163(19):2315-22.

Gottlieb DJ, DeStefano AL, Foley DJ, Mignot E, Redline S, Givelber RJ, Young T. APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: the Sleep Heart Health Study. Neurology. 2004  ;63(4):664-8.

Barzilay JI, Kronmal RA, Gottdiener JS, Smith NL, Burke GL, Tracy R, Savage PJ, Carlson M. The association of fasting glucose levels with congestive heart failure in diabetic adults > or =65 years: the Cardiovascular Health Study. J Am Coll Cardiol. 2004  ;43(12):2236-41.

Nordstrom CK, Roux AVDiez, Jackson SA, Gardin JM. The association of personal and neighborhood socioeconomic indicators with subclinical cardiovascular disease in an elderly cohort. The cardiovascular health study. Soc Sci Med. 2004  ;59(10):2139-47.

S Johnston C, O'Meara ES, Manolio TA, Lefkowitz D, O'Leary DH, Goldstein S, Carlson MC, Fried LP, Longstreth WT. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Ann Intern Med. 2004  ;140(4):237-47.

Mathew ST, Gottdiener JS, Kitzman D, Aurigemma G. Congestive heart failure in the elderly: the Cardiovascular Health Study. Am J Geriatr Cardiol. 2004  ;13(2):61-8.

Redline S, H Kirchner L, Quan SF, Gottlieb DJ, Kapur V, Newman A. The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med. 2004  ;164(4):406-18.

Drazner MH, J Rame E, Marino EK, Gottdiener JS, Kitzman DW, Gardin JM, Manolio TA, Dries DL, Siscovick DS. Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study. J Am Coll Cardiol. 2004  ;43(12):2207-15.

Seliger SL, Siscovick DS, Stehman-Breen CO, Gillen DL, Fitzpatrick A, Bleyer A, Kuller LH. Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol. 2004  ;15(7):1904-11.

Iber C, Redline S, Gilpin AMKaplan, Quan SF, Zhang L, Gottlieb DJ, Rapoport D, Resnick HE, Sanders M, Smith P. Polysomnography performed in the unattended home versus the attended laboratory setting--Sleep Heart Health Study methodology. Sleep. 2004  ;27(3):536-40.

Manolio TA, Cushman M, Gottdiener JS, Dobs A, Kuller LH, Kronmal RA. Predictors of falling cholesterol levels in older adults: the Cardiovascular Health Study. Ann Epidemiol. 2004  ;14(5):325-31.

Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol. 2004  ;160(6):521-30.

Smith NL, Chan JD, Rea TD, Wiggins KL, Gottdiener JS, Lumley T, Psaty BM. Time trends in the use of beta-blockers and other pharmacotherapies in older adults with congestive heart failure. Am Heart J. 2004  ;148(4):710-7.

Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, F Nieto J. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med. 2005  ;165(8):863-7.

Lenze EJ, Schulz R, Martire LM, Zdaniuk B, Glass T, Kop WJ, Jackson SA, Reynolds CF. The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study. J Am Geriatr Soc. 2005  ;53(4):569-75.

Seliger SL, Longstreth WT, Katz R, Manolio T, Fried LF, Shlipak M, Stehman-Breen CO, Newman A, Sarnak M, Gillen DL, et al. Cystatin C and subclinical brain infarction. J Am Soc Nephrol. 2005  ;16(12):3721-7.

Fried LF, Katz R, Sarnak MJ, Shlipak MG, Chaves PHM, Jenny NSwords, Stehman-Breen C, Gillen D, Bleyer AJ, Hirsch C, et al. Kidney function as a predictor of noncardiovascular mortality. J Am Soc Nephrol. 2005  ;16(12):3728-35.

Podewils LJean, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, Lyketsos CG. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005  ;161(7):639-51.

Newman AB, Foster G, Givelber R, F Nieto J, Redline S, Young T. Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study. Arch Intern Med. 2005  ;165(20):2408-13.

Kapur VK, Baldwin CM, Resnick HE, Gottlieb DJ, F Nieto J. Sleepiness in patients with moderate to severe sleep-disordered breathing. Sleep. 2005  ;28(4):472-7.

Stein PK, Domitrovich PP, Hui N, Rautaharju P, Gottdiener J. Sometimes higher heart rate variability is not better heart rate variability: results of graphical and nonlinear analyses. J Cardiovasc Electrophysiol. 2005  ;16(9):954-9.

Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, H Kirchner L, Sahadevan J, Redline S. Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study. Am J Respir Crit Care Med. 2006  ;173(8):910-6.

Hirsch C, Anderson ML, Newman A, Kop W, Jackson S, Gottdiener J, Tracy R, Fried LP. The association of race with frailty: the cardiovascular health study. Ann Epidemiol. 2006  ;16(7):545-53.

Gottlieb DJ, Redline S, F Nieto J, Baldwin CM, Newman AB, Resnick HE, Punjabi NM. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep. 2006  ;29(8):1009-14.

Barasch E, Gottdiener JS, Larsen EKMarino, Chaves PHM, Newman AB. Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study). Am J Cardiol. 2006  ;97(9):1281-6.

Conley YP, Jakobsdottir J, Mah T, Weeks DE, Klein R, Kuller L, Ferrell RE, Gorin MB. CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses. Hum Mol Genet. 2006  ;15(21):3206-18.

Barasch E, Gottdiener JS, Larsen EKMarino, Chaves PHM, Newman AB, Manolio TA. Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS). Am Heart J. 2006  ;151(1):39-47.

Rautaharju PM, Ge S, Nelson JC, Larsen EKMarino, Psaty BM, Furberg CD, Zhang Z-M, Robbins J, Gottdiener JS, Chaves PHM. Comparison of mortality risk for electrocardiographic abnormalities in men and women with and without coronary heart disease (from the Cardiovascular Health Study). Am J Cardiol. 2006  ;97(3):309-15.

Liao L, Jollis JG, Anstrom KJ, Whellan DJ, Kitzman DW, Aurigemma GP, Mark DB, Schulman KA, Gottdiener JS. Costs for heart failure with normal vs reduced ejection fraction. Arch Intern Med. 2006  ;166(1):112-8.

Mozaffarian D, Gottdiener JS, Siscovick DS. Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics. Am J Cardiol. 2006  ;97(2):216-22.

Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA. Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study). Am J Cardiol. 2006  ;97(1):83-9.

McNeill AMarie, Katz R, Girman CJ, Rosamond WD, Wagenknecht LE, Barzilay JI, Tracy RP, Savage PJ, Jackson SA. Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health study. J Am Geriatr Soc. 2006  ;54(9):1317-24.

Patwardhan AA, Larson MG, Levy D, Benjamin EJ, Leip EP, Keyes MJ, Wang TJ, Gottlieb DJ, Vasan RS. Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample. Sleep. 2006  ;29(10):1301-6.

Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, Kaszniak A, Boland LL, Caccappolo E, Bootzin RR. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med. 2006  ;7(6):498-507.

Buxbaum J, Jacobson DR, Tagoe C, Alexander A, Kitzman DW, Greenberg B, Thaneemit-Chen S, Lavori P. Transthyretin V122I in African Americans with congestive heart failure. J Am Coll Cardiol. 2006  ;47(8):1724-5.

Gardin JM, Arnold AM, Polak J, Jackson S, Smith V, Gottdiener J. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular Health Study). Am J Cardiol. 2006  ;97(2):270-5.

Mukamal KJ, Psaty BM, Rautaharju PM, Furberg CD, Kuller LH, Mittleman MA, Gottdiener JS, Siscovick DS. Alcohol consumption and risk and prognosis of atrial fibrillation among older adults: the Cardiovascular Health Study. Am Heart J. 2007  ;153(2):260-6.

Tikellis G, Sun C, Gorin MB, Klein R, Klein BEK, Larsen EKMarino, Siscovick DS, Hubbard LD, Wong TY. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. Arch Ophthalmol. 2007  ;125(1):68-73.

Novaro GM, Katz R, Aviles RJ, Gottdiener JS, Cushman M, Psaty BM, Otto CM, Griffin BP. Clinical factors, but not C-reactive protein, predict progression of calcific aortic-valve disease: the Cardiovascular Health Study. J Am Coll Cardiol. 2007  ;50(20):1992-8.

Ballantyne C, Cushman M, Psaty B, Furberg C, Khaw KT, Sandhu M, Oldgren J, Rossi GP, Maiolino G, Cesari M, et al. Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases. Eur J Cardiovasc Prev Rehabil. 2007  ;14(1):3-11.

Curtis LH, Hammill BG, M Bethel A, Anstrom KJ, Gottdiener JS, Schulman KA. Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health Study. Diabetes Care. 2007  ;30(10):2553-8.

Danesh J, Erqou S, Walker M, Thompson SG, Tipping R, Ford C, Pressel S, Walldius G, Jungner I, Folsom AR, et al. The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol. 2007  ;22(12):839-69.

Gottlieb DJ, O'Connor GT, Wilk JB. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet. 2007  ;8 Suppl 1:S9.

Lopez OL, Kuller LH, Becker JT, Dulberg C, Sweet RA, H Gach M, DeKosky ST. Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Arch Neurol. 2007  ;64(3):416-20.

Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, Aviv A. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007  ;165(1):14-21.

Liao L, Anstrom KJ, Gottdiener JS, Pappas PA, Whellan DJ, Kitzman DW, Aurigemma GP, Mark DB, Schulman KA, Jollis JG. Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study. Am Heart J. 2007  ;153(2):245-52.

Podewils LJ, Guallar E, Beauchamp N, Lyketsos CG, Kuller LH, Scheltens P. Physical activity and white matter lesion progression: assessment using MRI. Neurology. 2007  ;68(15):1223-6.

Silva GE, Goodwin JL, Sherrill DL, Arnold JL, Bootzin RR, Smith T, Walsleben JA, Baldwin CM, Quan SF. Relationship between reported and measured sleep times: the sleep heart health study (SHHS). J Clin Sleep Med. 2007  ;3(6):622-30.

Stein PK, Barzilay JI, Domitrovich PP, Chaves PM, Gottdiener JS, Heckbert SR, Kronmal RA. The relationship of heart rate and heart rate variability to non-diabetic fasting glucose levels and the metabolic syndrome: the Cardiovascular Health Study. Diabet Med. 2007  ;24(8):855-63.

Maurer MS, Burkhoff D, Fried LP, Gottdiener J, King DL, Kitzman DW. Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: the Cardiovascular Health Study. J Am Coll Cardiol. 2007  ;49(9):972-81.

Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, H Gach M. Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension. Stroke. 2008  ;39(2):349-54.

Kizer JR, Barzilay JI, Kuller LH, Gottdiener JS. Adiponectin and risk of coronary heart disease in older men and women. J Clin Endocrinol Metab. 2008  ;93(9):3357-64.

Fowkes FGR, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008  ;300(2):197-208.

Winkelman JW, Shahar E, Sharief I, Gottlieb DJ. Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. Neurology. 2008  ;70(1):35-42.

Mittalhenkle A, Stehman-Breen CO, Shlipak MG, Fried LF, Katz R, Young BA, Seliger S, Gillen D, Newman AB, Psaty BM, et al. Cardiovascular risk factors and incident acute renal failure in older adults: the cardiovascular health study. Clin J Am Soc Nephrol. 2008  ;3(2):450-6.

Moran A, Katz R, Smith NL, Fried LF, Sarnak MJ, Seliger SL, Psaty B, Siscovick DS, Gottdiener JS, Shlipak MG. Cystatin C concentration as a predictor of systolic and diastolic heart failure. J Card Fail. 2008  ;14(1):19-26.

Sharief I, Silva GE, Goodwin JL, Quan SF. Effect of sleep disordered breathing on the sleep of bed partners in the Sleep Heart Health Study. Sleep. 2008  ;31(10):1449-56.

Stamatakis K, Sanders MH, Caffo B, Resnick HE, Gottlieb DJ, Mehra R, Punjabi NM. Fasting glycemia in sleep disordered breathing: lowering the threshold on oxyhemoglobin desaturation. Sleep. 2008  ;31(7):1018-24.

Stein PK, Barzilay JI, Chaves PHM, Traber J, Domitrovich PP, Heckbert SR, Gottdiener JS. Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study. J Am Geriatr Soc. 2008  ;56(2):315-21.

Roddam AW, Allen NE, Appleby P, Key TJ, Ferrucci L, H Carter B, E Metter J, Chen C, Weiss NS, Fitzpatrick A, et al. Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies. Ann Intern Med. 2008  ;149(7):461-71, W83-8.

Crane PK, Narasimhalu K, Gibbons LE, Mungas DM, Haneuse S, Larson EB, Kuller L, Hall K, van Belle G. Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline. J Clin Epidemiol. 2008  ;61(10):1018-27.e9.

de Simone G, Gottdiener JS, Chinali M, Maurer MS. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study. Eur Heart J. 2008  ;29(6):741-7.

Chami HA, Devereux RB, Gottdiener JS, Mehra R, Roman MJ, Benjamin EJ, Gottlieb DJ. Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study. Circulation. 2008  ;117(20):2599-607.

Szekely CA, Green RC, Breitner JCS, stbye TØ, Beiser AS, Corrada MM, Dodge HH, Ganguli M, Kawas CH, Kuller LH, et al. No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology. 2008  ;70(24):2291-8.

Stein PK, Barzilay JI, Chaves PHM, Mistretta SQ, Domitrovich PP, Gottdiener JS, Rich MW, Kleiger RE. Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS). J Cardiovasc Electrophysiol. 2008  ;19(11):1169-74.

Curtis LH, Hammill BG, M Bethel A, Anstrom KJ, Liao L, Gottdiener JS, Schulman KA. Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study. Curr Med Res Opin. 2008  ;24(1):41-50.

Lopez OL, Kuller LH, Mehta PD, Becker JT, Gach HM, Sweet RA, Chang YF, Tracy R, DeKosky ST. Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study. Neurology. 2008  ;70(19):1664-71.

Reiner AP, Barber MJ, Guan Y, Ridker PM, Lange LA, Chasman DI, Walston JD, Cooper GM, Jenny NS, Rieder MJ, et al. Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet. 2008  ;82(5):1193-201.

Kapur VK, Resnick HE, Gottlieb DJ. Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association?. Sleep. 2008  ;31(8):1127-32.

Seicean S, H Kirchner L, Gottlieb DJ, Punjabi NM, Resnick H, Sanders M, Budhiraja R, Singer M, Redline S. Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study. Diabetes Care. 2008  ;31(5):1001-6.

Rodondi N, Bauer DC, Cappola AR, Cornuz J, Robbins J, Fried LP, Ladenson PW, Vittinghoff E, Gottdiener JS, Newman AB. Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health study. J Am Coll Cardiol. 2008  ;52(14):1152-9.

Sink KM, Leng X, Williamson J, Kritchevsky SB, Yaffe K, Kuller L, Yasar S, Atkinson H, Robbins M, Psaty B, et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med. 2009  ;169(13):1195-202.

Barasch E, Gottdiener JS, Aurigemma G, Kitzman DW, Han J, Kop WJ, Tracy RP. Association between elevated fibrosis markers and heart failure in the elderly: the cardiovascular health study. Circ Heart Fail. 2009  ;2(4):303-10.

Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen M-H, Baumert J, Lowe GDO, et al. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet. 2009  ;2(2):125-33.

Asselbergs FW, Mozaffarian D, Katz R, Kestenbaum B, Fried LF, Gottdiener JS, Shlipak MG, Siscovick DS. Association of renal function with cardiac calcifications in older adults: the cardiovascular health study. Nephrol Dial Transplant. 2009  ;24(3):834-40.

Chami HA, Keyes MJ, Vita JA, Mitchell GF, Larson MG, Fan S, Vasan RS, O'Connor GT, Benjamin EJ, Gottlieb DJ. Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing. Vasc Med. 2009  ;14(4):351-60.

Psaty BM, O'Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, Rotter JI, Uitterlinden AG, Harris TB, Witteman JCM, Boerwinkle E. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet. 2009  ;2(1):73-80.

Reiner AP, Gross MD, Carlson CS, Bielinski SJ, Lange LA, Fornage M, Jenny NS, Walston J, Tracy RP, O Williams D, et al. Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascula. Circ Cardiovasc Genet. 2009  ;2(3):244-54.

DiMartino LD, Hammill BG, Curtis LH, Gottdiener JS, Manolio TA, Powe NR, Schulman KA. External validity of the cardiovascular health study: a comparison with the Medicare population. Med Care. 2009  ;47(8):916-23.

Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, et al. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA. 2009  ;302(2):168-78.

Bis JC, Glazer NL, Psaty BM. Genome-wide association studies of cardiovascular risk factors: design, conduct and interpretation. J Thromb Haemost. 2009  ;7 Suppl 1:308-11.

Ikram AM, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, et al. Genomewide association studies of stroke. N Engl J Med. 2009  ;360(17):1718-28.

Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009  ;41(6):677-87.

Stein PK, Barzilay JI, Chaves PHM, Domitrovich PP, Gottdiener JS. Heart rate variability and its changes over 5 years in older adults. Age Ageing. 2009  ;38(2):212-8.

Lee C, Lopez OL, Becker JT, Raji C, Dai W, Kuller LH, H Gach M. Imaging cerebral blood flow in the cognitively normal aging brain with arterial spin labeling: implications for imaging of neurodegenerative disease. J Neuroimaging. 2009  ;19(4):344-52.

Kaplan RC, Fitzpatrick AL, Pollak MN, Gardner JP, Jenny NS, McGinn AP, Kuller LH, Strickler HD, Kimura M, Psaty BM, et al. Insulin-like growth factors and leukocyte telomere length: the cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2009  ;64(11):1103-6.

Aurigemma GP, Gottdiener JS, Arnold AM, Chinali M, Hill JC, Kitzman D. Left atrial volume and geometry in healthy aging: the Cardiovascular Health Study. Circ Cardiovasc Imaging. 2009  ;2(4):282-9.

Silva GE, An M-W, Goodwin JL, Shahar E, Redline S, Resnick H, Baldwin CM, Quan SF. Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS). Sleep. 2009  ;32(8):1049-57.

Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, H Gach M. Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology. 2009  ;250(3):856-66.

Köttgen A, Glazer NL, Dehghan A, Hwang S-J, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 2009  ;41(6):712-7.

Ganesh SK, Zakai NA, van Rooij FJA, Soranzo N, Smith AV, Nalls MA, Chen M-H, Köttgen A, Glazer NL, Dehghan A, et al. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet. 2009  ;41(11):1191-8.

Heard-Costa NL, Zillikens CM, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 2009  ;5(6):e1000539.

Patton KK, Ellinor PT, Heckbert SR, Christenson RH, DeFilippi C, Gottdiener JS, Kronmal RA. N-terminal pro-B-type natriuretic peptide is a major predictor of the development of atrial fibrillation: the Cardiovascular Health Study. Circulation. 2009  ;120(18):1768-74.

Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. Sleep. 2009  ;32(6):772-8.

Parashar S, Katz R, Smith NL, Arnold AM, Vaccarino V, Wenger NK, Gottdiener JS. Race, gender, and mortality in adults > or =65 years of age with incident heart failure (from the Cardiovascular Health Study). Am J Cardiol. 2009  ;103(8):1120-7.

N Yanez D, Burke GL, Manolio T, Gardin JM, Polak J. Sibling history of myocardial infarction or stroke and risk of cardiovascular disease in the elderly: the Cardiovascular Health Study. Ann Epidemiol. 2009  ;19(12):858-66.

Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 2009  ;6(8):e1000132.

Jackson D, White I, Kostis JB, Wilson AC, Folsom AR, Wu K, Chambless L, Benderly M, Goldbourt U, Willeit J, et al. Systematically missing confounders in individual participant data meta-analysis of observational cohort studies. Stat Med. 2009  ;28(8):1218-37.

Cappola AR, O'Meara ES, Guo W, Bartz TM, Fried LP, Newman AB. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2009  ;64(12):1268-74.

Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009  ;41(8):879-81.

Odden MC, Tager IB, Gansevoort RT, Bakker SJL, Katz R, Fried LF, Newman AB, Canada RB, Harris T, Sarnak MJ, et al. Age and cystatin C in healthy adults: a collaborative study. Nephrol Dial Transplant. 2010  ;25(2):463-9.

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HLango, Lindgren CM, Luan J'an, Mägi R, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010  ;42(11):937-48.

Kop WJ, Kuhl EA, Barasch E, Jenny NS, Gottlieb SS, Gottdiener JS. Association between depressive symptoms and fibrosis markers: the Cardiovascular Health Study. Brain Behav Immun. 2010  ;24(2):229-35.

Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Cupples AL, Dehghan A, Lumley T, Rosamond WD, et al. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Circ Cardiovasc Genet. 2010  ;3(3):256-66.

Stein PK, Sanghavi D, Sotoodehnia N, Siscovick DS, Gottdiener J. Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health Study. J Electrocardiol. 2010  ;43(3):251-9.

deFilippi CR, de Lemos JA, Christenson RH, Gottdiener JS, Kop WJ, Zhan M, Seliger SL. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA. 2010  ;304(22):2494-502.

Zanobetti A, Redline S, Schwartz J, Rosen D, Patel S, O'Connor GT, Lebowitz M, Coull BA, Gold DR. Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas. Am J Respir Crit Care Med. 2010  ;182(6):819-25.

Kop WJ, Stein PK, Tracy RP, Barzilay JI, Schulz R, Gottdiener JS. Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med. 2010  ;72(7):626-35.

Burgess S, Thompson SG, Burgess S, Thompson SG, Andrews G, Samani NJ, Hall A, Whincup P, Morris R, Lawlor DA, et al. Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Stat Med. 2010  ;29(12):1298-311.

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010  ;466(7307):707-13.

Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen M-H, Lapchyk N, et al. Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet. 2010  ;3(3):267-75.

Wang TJ, Zhang F, J Richards B, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010  ;376(9736):180-8.

Kestenbaum B, Glazer NL, Köttgen A, Felix JF, Hwang S-J, Liu Y, Lohman K, Kritchevsky SB, Hausman DB, Petersen A-K, et al. Common genetic variants associate with serum phosphorus concentration. J Am Soc Nephrol. 2010  ;21(7):1223-32.

Sotoodehnia N, Isaacs A, de Bakker PIW, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010  ;42(12):1068-76.

Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PIW, Mueller M, Lubitz SA, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010  ;42(3):240-4.

O'Seaghdha CM, Yang Q, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao LWH, Lohman K, Hwang S-J, Johnson AD, et al. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet. 2010  ;19(21):4296-303.

Sarwar N, Gao P, Seshasai SRKondapal, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010  ;375(9733):2215-22.

Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen L-K, Gokulakrishnan K, Hanefeld M, Ingelsson E, et al. Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One. 2010  ;5(10):e13405.

deFilippi CR, Christenson RH, Gottdiener JS, Kop WJ, Seliger SL. Dynamic cardiovascular risk assessment in elderly people. The role of repeated N-terminal pro-B-type natriuretic peptide testing. J Am Coll Cardiol. 2010  ;55(5):441-50.

M Ikram K, Sim X, Xueling S, Jensen RA, Cotch MFrances, Hewitt AW, Ikram AM, Wang JJin, Klein R, Klein BEK, et al. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 2010  ;6(10):e1001184.

McGovern DPB, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, et al. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet. 2010  ;19(17):3468-76.

Kumar R, Seibold MA, Aldrich MC, L Williams K, Reiner AP, Colangelo L, Galanter J, Gignoux C, Hu D, Sen S, et al. Genetic ancestry in lung-function predictions. N Engl J Med. 2010  ;363(4):321-30.

Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, et al. Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis. 2010  ;16(11):1830-40.

Seshadri S, Fitzpatrick AL, Ikram AM, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JCharles, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010  ;303(18):1832-40.

Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PIW, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, et al. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010  ;19(19):3885-94.

McGovern DPB, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RTH, Lagacé C, Li C, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010  ;42(4):332-7.

Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang S-J, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010  ;107(20):9293-8.

Debette S, Bis JC, Fornage M, Schmidt H, Ikram AM, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, et al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke. 2010  ;41(2):210-7.

Meyer TE, Verwoert GC, Hwang S-J, Glazer NL, Smith AV, van Rooij FJA, Ehret GB, Boerwinkle E, Felix JF, Leak TS, et al. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet. 2010  ;6(8).

Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, Smith AVernon, Tarasov KV, Müller M, Sotoodehnia N, Sinner MF, et al. Genome-wide association study of PR interval. Nat Genet. 2010  ;42(2):153-9.

Franke A, McGovern DPB, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010  ;42(12):1118-25.

Morrison AC, Felix JF, Cupples AL, Glazer NL, Loehr LR, Dehghan A, Demissie S, Bis JC, Rosamond WD, Aulchenko YS, et al. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet. 2010  ;3(3):248-55.

Chaudhry SI, McAvay G, Ning Y, Allore HG, Newman AB, Gill TM. Geriatric impairments and disability: the cardiovascular health study. J Am Geriatr Soc. 2010  ;58(9):1686-92.

Allen HLango, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010  ;467(7317):832-8.

Lubitz SA, Sinner MF, Lunetta KL, Makino S, Pfeufer A, Rahman R, Veltman CE, Barnard J, Bis JC, Danik SP, et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation. 2010  ;122(10):976-84.

Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E, Wojczynski MK, Ye Z, et al. Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care. 2010  ;33(12):2684-91.

Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010  ;19(9):1863-72.

Thompson A, Gao P, Orfei L, Watson S, Di Angelantonio E, Kaptoge S, Ballantyne C, Cannon CP, Criqui M, Cushman M, et al. Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet. 2010  ;375(9725):1536-44.

Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YMTA, Chen T-H, R Barr G, et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 2010  ;42(1):45-52.

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens CM, Speliotes EK, Mägi R, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010  ;42(11):949-60.

Newman AB, Walter S, Lunetta KL, Garcia ME, P Slagboom E, Christensen K, Arnold AM, Aspelund T, Aulchenko YS, Benjamin EJ, et al. A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci. 2010  ;65(5):478-87.

Yang Q, Köttgen A, Dehghan A, Smith AV, Glazer NL, Chen M-H, Chasman DI, Aspelund T, Eiriksdottir G, Harris TB, et al. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet. 2010  ;3(6):523-30.

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010  ;42(2):105-16.

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, et al. New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010  ;42(5):376-84.

Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010  ;182(2):269-77.

Hirsch CH, Diehr P, Newman AB, Gerrior SA, Pratt C, Lebowitz MD, Jackson SA. Physical activity and years of healthy life in older adults: results from the cardiovascular health study. J Aging Phys Act. 2010  ;18(3):313-34.

Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C, Newman AB, Gach HM, Thompson PM, Ho AJ, Kuller LH. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology. 2010  ;75(16):1415-22.

de Weerd M, Greving JP, Hedblad B, Lorenz MW, Mathiesen EB, O'Leary DH, Rosvall M, Sitzer M, Buskens E, Bots ML. Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis. Stroke. 2010  ;41(6):1294-7.

Gottlieb DJ, Yenokyan G, Newman AB, O'Connor GT, Punjabi NM, Quan SF, Redline S, Resnick HE, Tong EK, Diener-West M, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010  ;122(4):352-60.

Chami HA, Baldwin CM, Silverman A, Zhang Y, Rapoport D, Punjabi NM, Gottlieb DJ. Sleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathing. Am J Respir Crit Care Med. 2010  ;181(9):997-1002.

Rodondi N, Elzen WPJ den, Bauer DC, Cappola AR, Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi M, Collet T-H, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010  ;304(12):1365-74.

Schnabel RB, Aspelund T, Li G, Sullivan LM, Suchy-Dicey A, Harris TB, Pencina MJ, D'Agostino RB, Levy D, Kannel WB, et al. Validation of an atrial fibrillation risk algorithm in whites and African Americans. Arch Intern Med. 2010  ;170(21):1909-17.

Kalogeropoulos A, Psaty BM, Vasan RS, Georgiopoulou V, Smith AL, Smith NL, Kritchevsky SB, Wilson PWF, Newman AB, Harris TB, et al. Validation of the health ABC heart failure model for incident heart failure risk prediction: the Cardiovascular Health Study. Circ Heart Fail. 2010  ;3(4):495-502.

Rodriguez CJ, Bartz TM, Longstreth WT, Kizer JR, Barasch E, Lloyd-Jones DM, Gottdiener JS. Association of annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults: the cardiovascular health study. J Am Coll Cardiol. 2011  ;57(21):2172-80.

Böger CA, Gorski M, Li M, Hoffmann MM, Huang C, Yang Q, Teumer A, Krane V, O'Seaghdha CM, Kutalik Z, et al. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genet. 2011  ;7(9):e1002292.

Franceschini N, Carty C, B?zková P, Reiner AP, Garrett T, Lin Y, Vöckler J-S, Hindorff LA, Cole SA, Boerwinkle E, et al. Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. Circ Cardiovasc Genet. 2011  ;4(6):661-72.

Fox ER, Young HJ, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, et al. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011  ;20(11):2273-84.

Wassel CL, Lange LA, Keating BJ, Taylor KC, Johnson AD, Palmer C, Ho LA, Smith NL, Lange EM, Li Y, et al. Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). Blood. 2011  ;117(1):268-75.

Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC, Launer LJ, Gudnason V, et al. Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension. 2011  ;57(5):903-10.

Chami HA, Resnick HE, Quan SF, Gottlieb DJ. Association of incident cardiovascular disease with progression of sleep-disordered breathing. Circulation. 2011  ;123(12):1280-6.

Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, Sovio U, Mathias RA, Sun YV, Franceschini N, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011  ;60(4):1329-39.

Sobrin L, Green T, Sim X, Jensen RA, Tai SE, Tay WTing, Wang JJin, Mitchell P, Sandholm N, Liu Y, et al. Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci. 2011  ;52(10):7593-602.

Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, et al. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011  ;21(5):280-8.

Pandhi J, Gottdiener JS, Bartz TM, Kop WJ, Mehra MR. Comparison of characteristics and outcomes of asymptomatic versus symptomatic left ventricular dysfunction in subjects 65 years old or older (from the Cardiovascular Health Study). Am J Cardiol. 2011  ;107(11):1667-74.

Böger CA, Chen M-H, Tin A, Olden M, Köttgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, et al. CUBN is a gene locus for albuminuria. J Am Soc Nephrol. 2011  ;22(3):555-70.

Win S, Parakh K, Eze-Nliam CM, Gottdiener JS, Kop WJ, Ziegelstein RC. Depressive symptoms, physical inactivity and risk of cardiovascular mortality in older adults: the Cardiovascular Health Study. Heart. 2011  ;97(6):500-5.

Seshasai SRao Kondap, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011  ;364(9):829-841.

Reshef S, Fried L, Beauchamp N, Scharfstein D, Reshef D, Goodman S. Diastolic blood pressure levels and ischemic stroke incidence in older adults with white matter lesions. J Gerontol A Biol Sci Med Sci. 2011  ;66(1):74-81.

Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EBarrett, et al. Gait speed and survival in older adults. JAMA. 2011  ;305(1):50-8.

Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, Smith NL, Delaney JA, Kumari M, Hingorani A, et al. A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet. 2011  ;20(17):3525-34.

Liu C-T, Garnaas MK, Tin A, Köttgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Atkinson E, Ding J, et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 2011  ;7(9):e1002264.

Lemaitre RN, Tanaka T, Tang W, Manichaikul A, Foy M, Kabagambe EK, Nettleton JA, King IB, Weng L-C, Bhattacharya S, et al. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet. 2011  ;7(7):e1002193.

Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin S-Y, Baumert J, Vitart V, et al. Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011  ;123(17):1864-72.

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang S-J, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011  ;478(7367):103-9.

Schmidt H, Zeginigg M, Wiltgen M, Freudenberger P, Petrovic K, Cavalieri M, Gider P, Enzinger C, Fornage M, Debette S, et al. Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease. Brain. 2011  ;134(Pt 11):3384-97.

Kilpeläinen TO, Zillikens CM, Stan?áková A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J'an, Vandenput L, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011  ;43(8):753-60.

Artigas MSoler, Loth DW, Wain LV, Gharib SA, Obeidat M'en, Tang W, Zhai G, Zhao JH, Smith AVernon, Huffman JE, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011  ;43(11):1082-90.

Fornage M, Debette S, Bis JC, Schmidt H, Ikram AM, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, et al. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol. 2011  ;69(6):928-39.

Kaplan RC, Petersen A-K, Chen M-H, Teumer A, Glazer NL, Döring A, Lam CSP, Friedrich N, Newman A, Müller M, et al. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet. 2011  ;20(6):1241-51.

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011  ;43(10):1005-11.

Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, et al. A genome-wide association study of aging. Neurobiol Aging. 2011  ;32(11):2109.e15-28.

Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, et al. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY). 2011  ;3(1):63-76.

Arking DE, M Junttila J, Goyette P, Huertas-Vazquez A, Eijgelsheim M, Blom MT, Newton-Cheh C, Reinier K, Teodorescu C, Uy-Evanado A, et al. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet. 2011  ;7(6):e1002158.

Silva GE, Vana KD, Goodwin JL, Sherrill DL, Quan SF. Identification of patients with sleep disordered breathing: comparing the four-variable screening tool, STOP, STOP-Bang, and Epworth Sleepiness Scales. J Clin Sleep Med. 2011  ;7(5):467-72.

Brown MA, Goodwin JL, Silva GE, Behari A, Newman AB, Punjabi NM, Resnick HE, Robbins JA, Quan SF. The Impact of Sleep-Disordered Breathing on Body Mass Index (BMI): The Sleep Heart Health Study (SHHS). Southwest J Pulm Crit Care. 2011  ;3:159-168.

Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, et al. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011  ;4(5):557-64.

deFilippi CR, Christenson RH, Kop WJ, Gottdiener JS, Zhan M, Seliger SL. Left ventricular ejection fraction assessment in older adults: an adjunct to natriuretic peptide testing to identify risk of new-onset heart failure and cardiovascular death?. J Am Coll Cardiol. 2011  ;58(14):1497-506.

Fitzpatrick AL, Kronmal RA, Kimura M, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Hardikar S, Aviv A. Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2011  ;66(4):421-9.

Kop WJ, Seliger SL, Fink JC, Katz R, Odden MC, Fried LF, Rifkin DE, Sarnak MJ, Gottdiener JS. Longitudinal association of depressive symptoms with rapid kidney function decline and adverse clinical renal disease outcomes. Clin J Am Soc Nephrol. 2011  ;6(4):834-44.

Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J. Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts. Kidney Int. 2011  ;80(1):93-104.

Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U, Post WS, Smith AV, Cupples AL, Markus HS, et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet. 2011  ;43(10):940-7.

Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, et al. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011  ;123(7):731-8.

Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 2011  ;480(7376):201-8.

Patton KK, Sotoodehnia N, DeFilippi C, Siscovick DS, Gottdiener JS, Kronmal RA. N-terminal pro-B-type natriuretic peptide is associated with sudden cardiac death risk: the Cardiovascular Health Study. Heart Rhythm. 2011  ;8(2):228-33.

van den Broek KC, deFilippi CR, Christenson RH, Seliger SL, Gottdiener JS, Kop WJ. Predictive value of depressive symptoms and B-type natriuretic peptide for new-onset heart failure and mortality. Am J Cardiol. 2011  ;107(5):723-9.

Barasch E, Gottdiener JS, Aurigemma G, Kitzman DW, Han J, Kop WJ, Tracy RP. The relationship between serum markers of collagen turnover and cardiovascular outcome in the elderly: the Cardiovascular Health Study. Circ Heart Fail. 2011  ;4(6):733-9.

Chaudhry SI, McAvay G, Ning Y, Allore HG, Newman AB, Gill TM. Risk factors for onset of disability among older persons newly diagnosed with heart failure: the Cardiovascular Health Study. J Card Fail. 2011  ;17(9):764-70.

Butler J, Kalogeropoulos AP, Georgiopoulou VV, Bibbins-Domingo K, Najjar SS, Sutton-Tyrrell KC, Harris TB, Kritchevsky SB, Lloyd-Jones DM, Newman AB, et al. Systolic blood pressure and incident heart failure in the elderly. The Cardiovascular Health Study and the Health, Ageing and Body Composition Study. Heart. 2011  ;97(16):1304-11.

Kanoni S, Nettleton JA, Hivert M-F, Ye Z, van Rooij FJA, Shungin D, Sonestedt E, Ngwa JS, Wojczynski MK, Lemaitre RN, et al. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes. 2011  ;60(9):2407-16.

Djoussé L, Bartz TM, Ix JH, Zieman SJ, Delaney JA, Mukamal KJ, Gottdiener JS, Siscovick DS, Kizer JR. Adiposity and incident heart failure in older adults: the cardiovascular health study. Obesity (Silver Spring). 2012  ;20(9):1936-41.

Hallan SI, Matsushita K, Sang Y, Mahmoodi BK, Black C, Ishani A, Kleefstra N, Naimark D, Roderick P, Tonelli M, et al. Age and association of kidney measures with mortality and end-stage renal disease. JAMA. 2012  ;308(22):2349-60.

Liu C-T, Estrada K, Yerges-Armstrong LM, Amin N, Evangelou E, Li G, Minster RL, Carless MA, Kammerer CM, Oei L, et al. Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res. 2012  ;27(10):2051-64.

Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al. Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet. 2012  ;5(1):100-12.

de Hollander EL, Bemelmans WJe, Boshuizen HC, Friedrich N, Wallaschofski H, Guallar-Castillón P, Walter S, Zillikens CM, Rosengren A, Lissner L, et al. The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. Int J Epidemiol. 2012  ;41(3):805-17.

Patel SR, Goodloe R, De G, Kowgier M, Weng J, Buxbaum SG, Cade B, Fulop T, Gharib SA, Gottlieb DJ, et al. Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe). PLoS One. 2012  ;7(11):e48836.

Mahmoodi BK, Gansevoort RT, Næss IAnne, Lutsey PL, Brækkan SK, Veeger NJGM, Brodin EE, Meijer K, Sang Y, Matsushita K, et al. Association of mild to moderate chronic kidney disease with venous thromboembolism: pooled analysis of five prospective general population cohorts. Circulation. 2012  ;126(16):1964-71.

Carnethon MR, De Chavez PJohn D, Biggs ML, Lewis CE, Pankow JS, Bertoni AG, Golden SH, Liu K, Mukamal KJ, Campbell-Jenkins B, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012  ;308(6):581-90.

Kop WJ, Gottdiener JS, deFilippi CR, Barasch E, Seliger SL, Jenny NS, Christenson RH. Cardiac microinjury measured by troponin T predicts collagen metabolism in adults aged >=65 years with heart failure. Circ Heart Fail. 2012  ;5(4):406-13.

Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen T-P, Sander D, Plichart M, Catapano AL, Robertson CM, et al. Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data. Lancet. 2012  ;379(9831):2053-62.

Rajagopalan P, Jahanshad N, Stein JL, Hua X, Madsen SK, Kohannim O, Hibar DP, Toga AW, Jack CR, Saykin AJ, et al. Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. Neuroimage Clin. 2012  ;1(1):179-87.

Walford GA, Green T, Neale B, Isakova T, Rotter JI, Grant SFA, Fox CS, Pankow JS, Wilson JG, Meigs JB, et al. Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism. Diabetologia. 2012  ;55(2):331-9.

Matsushita K, Mahmoodi BK, Woodward M, Emberson JR, Jafar TH, Jee SHa, Polkinghorne KR, Shankar A, Smith DH, Tonelli M, et al. Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA. 2012  ;307(18):1941-51.

Haiman CA, Fesinmeyer MD, Spencer KL, B?zková P, V Voruganti S, Wan P, Haessler J, Franceschini N, Monroe KR, Howard BV, et al. Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium. Diabetes. 2012  ;61(6):1642-7.

Rosenberg MA, Gottdiener JS, Heckbert SR, Mukamal KJ. Echocardiographic diastolic parameters and risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012  ;33(7):904-12.

Kalogeropoulos AP, Georgiopoulou VV, deFilippi CR, Gottdiener JS, Butler J. Echocardiography, natriuretic peptides, and risk for incident heart failure in older adults: the Cardiovascular Health Study. JACC Cardiovasc Imaging. 2012  ;5(2):131-40.

Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, et al. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. Eur Heart J. 2012  ;33(2):238-51.

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science. 2012  ;337(6090):64-9.

Yang J, Loos RJF, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012  ;490(7419):267-72.

Wassel CL, Lamina C, Nambi V, Coassin S, Mukamal KJ, Ganesh SK, Jacobs DR, Franceschini N, Papanicolaou GJ, Gibson Q, et al. Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis. 2012  ;222(1):138-47.

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng Y-C, Fornage M, Ikram AM, Malik R, Bevan S, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 2012  ;11(11):951-62.

Williams JM, Johnson AC, Stelloh C, Dreisbach AW, Franceschini N, Regner KR, Townsend RR, Roman RJ, Garrett MR. Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. Hypertension. 2012  ;60(5):1157-68.

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen M-H, Tin A, Taliun D, et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 2012  ;8(3):e1002584.

Wilk JB, Shrine NRG, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AVernon, Heckbert SR, Smolonska J, Tang W, et al. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012  ;186(7):622-32.

Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin S-Y, Ding J, Baumert J, Oudot-Mellakh T, Folkersen L, Johnson AD, et al. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012  ;120(24):4873-81.

Hancock DB, Artigas MSoler, Gharib SA, Henry A, Manichaikul A, Ramasamy A, Loth DW, Imboden M, Koch B, McArdle WL, et al. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012  ;8(12):e1003098.

Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012  ;44(5):491-501.

Mangino M, Hwang S-J, Spector TD, Hunt SC, Kimura M, Fitzpatrick AL, Christiansen L, Petersen I, Elbers CC, Harris T, et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet. 2012  ;21(24):5385-94.

Girotra S, Kitzman DW, Kop WJ, Stein PK, Gottdiener JS, Mukamal KJ. Heart rate response to a timed walk and cardiovascular outcomes in older adults: the cardiovascular health study. Cardiology. 2012  ;122(2):69-75.

Zieman SJ, Kamineni A, Ix JH, Barzilay J, Djoussé L, Kizer JR, Biggs ML, de Boer IH, Chonchol M, Gottdiener JS, et al. Hemoglobin A1c and arterial and ventricular stiffness in older adults. PLoS One. 2012  ;7(10):e47941.

Rosenberg MA, Patton KK, Sotoodehnia N, Karas MG, Kizer JR, Zimetbaum PJ, Chang JD, Siscovick D, Gottdiener JS, Kronmal RA, et al. The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012  ;33(21):2709-17.

Lopez OL, Becker JT, Chang Y-F, Sweet RA, DeKosky ST, Gach MH, Carmichael OT, McDade E, Kuller LH. Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. Neurology. 2012  ;79(15):1599-606.

Britton KA, Mukamal KJ, Ix JH, Siscovick DS, Newman AB, de Boer IH, Thacker EL, Biggs ML, J Gaziano M, Djoussé L. Insulin resistance and incident peripheral artery disease in the Cardiovascular Health Study. Vasc Med. 2012  ;17(2):85-93.

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J'an, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012  ;44(9):991-1005.

Puhan MA, Hansel NN, Sobradillo P, Enright P, Lange P, Hickson D, Menezes AM, Riet Gter, Held U, Domingo-Salvany A, et al. Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts. BMJ Open. 2012  ;2(6).

Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P, Van Horn L, Tracy RP, Lloyd-Jones DM. Lifetime risks of cardiovascular disease. N Engl J Med. 2012  ;366(4):321-9.

Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A, Butterworth AS, Sarwar N, Wormser D, Saleheen D, et al. Lipid-related markers and cardiovascular disease prediction. JAMA. 2012  ;307(23):2499-506.

Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012  ;44(3):260-8.

Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012  ;44(6):670-5.

Musunuru K, Romaine SPR, Lettre G, Wilson JG, Volcik KA, Tsai MY, Taylor HA, Schreiner PJ, Rotter JI, Rich SS, et al. Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. PLoS One. 2012  ;7(5):e36473.

Parthasarathy S, Fitzgerald MP, Goodwin JL, Unruh M, Guerra S, Quan SF. Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort. PLoS One. 2012  ;7(2):e30969.

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen L-P, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012  ;8(3):e1002607.

deFilippi CR, de Lemos JA, Tkaczuk AT, Christenson RH, Carnethon MR, Siscovick DS, Gottdiener JS, Seliger SL. Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults. J Am Coll Cardiol. 2012  ;60(24):2539-47.

Collet T-H, Gussekloo J, Bauer DC, Elzen WPJ den, Cappola AR, Balmer P, Iervasi G, Asvold BO, Sgarbi JA, Völzke H, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012  ;172(10):799-809.

Gencer B, Collet T-H, Virgini V, Bauer DC, Gussekloo J, Cappola AR, Nanchen D, Elzen WPJ den, Balmer P, Luben RN, et al. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation. 2012  ;126(9):1040-9.

Glazer NL, Macy EM, Lumley T, Smith NL, Reiner AP, Psaty BM, King GL, Tracy RP, Siscovick DS. Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study. Cytokine. 2012  ;60(2):341-5.

Chiang CWK, Liu C-T, Lettre G, Lange LA, Jorgensen NW, Keating BJ, Vedantam S, Nock NL, Franceschini N, Reiner AP, et al. Ultraconserved elements in the human genome: association and transmission analyses of highly constrained single-nucleotide polymorphisms. Genetics. 2012  ;192(1):253-66.

Raji CA, Lopez OL, Kuller LH, Carmichael OT, Longstreth WT, H Gach M, Boardman J, Bernick CB, Thompson PM, Becker JT. White matter lesions and brain gray matter volume in cognitively normal elders. Neurobiol Aging. 2012  ;33(4):834.e7-16.

Zhang L, Spencer KL, V Voruganti S, Jorgensen NW, Fornage M, Best LG, Brown-Gentry KD, Cole SA, Crawford DC, Deelman E, et al. Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. Am J Epidemiol. 2013  ;177(9):923-32.

Broer L, Demerath EW, Garcia ME, Homuth G, Kaplan RC, Lunetta KL, Tanaka T, Tranah GJ, Walter S, Arnold AM, et al. Association of heat shock proteins with all-cause mortality. Age (Dordr). 2013  ;35(4):1367-76.

Dewland TA, Vittinghoff E, Mandyam MC, Heckbert SR, Siscovick DS, Stein PK, Psaty BM, Sotoodehnia N, Gottdiener JS, Marcus GM. Atrial ectopy as a predictor of incident atrial fibrillation: a cohort study. Ann Intern Med. 2013  ;159(11):721-8.

Thacker EL, McKnight B, Psaty BM, Longstreth WT, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013  ;81(2):119-25.

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples AL, Fornage M, et al. Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One. 2013  ;8(7):e68095.

Suchy-Dicey AM, Wallace ER, Mitchell SVElkind, Aguilar M, Gottesman RF, Rice K, Kronmal R, Psaty BM, Longstreth WT. Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study. Am J Hypertens. 2013  ;26(10):1210-7.

Hussein AA, Gottdiener JS, Bartz TM, Sotoodehnia N, DeFilippi C, Dickfeld T, Deo R, Siscovick D, Stein PK, Lloyd-Jones D. Cardiomyocyte injury assessed by a highly sensitive troponin assay and sudden cardiac death in the community: the Cardiovascular Health Study. J Am Coll Cardiol. 2013  ;62(22):2112-20.

Ruijter HM den, Peters SAE, Groenewegen KA, Anderson TJ, Britton AR, Dekker JM, Engstrom G, Eijkemans MJ, Evans GW, de Graaf J, et al. Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative. Diabetologia. 2013  ;56(7):1494-502.

van Meurs JBJ, Paré G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013  ;98(3):668-76.

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013  ;45(11):1345-52.

Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, et al. Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013  ;24(12):2105-17.

Shlipak MG, Matsushita K, Arnlöv J, Inker LA, Katz R, Polkinghorne KR, Rothenbacher D, Sarnak MJ, Astor BC, Coresh J, et al. Cystatin C versus creatinine in determining risk based on kidney function. N Engl J Med. 2013  ;369(10):932-43.

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013  ;45(11):1274-1283.

Fesinmeyer MD, North KE, Lim U, B?zková P, Crawford DC, Haessler J, Gross MD, Fowke JH, Goodloe R, Love S-A, et al. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med Genet. 2013  ;14:6.

Norton N, Li D, Rampersaud E, Morales A, Martin ER, Zuchner S, Guo S, Gonzalez M, Hedges DJ, Robertson PD, et al. Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circ Cardiovasc Genet. 2013  ;6(2):144-53.

Djoussé L, Bartz TM, Ix JH, Kochar J, Kizer JR, Gottdiener JS, Tracy RP, Mozaffarian D, Siscovick DS, Mukamal KJ, et al. Fatty acid-binding protein 4 and incident heart failure: the Cardiovascular Health Study. Eur J Heart Fail. 2013  ;15(4):394-9.

Jovanovich A, Ix JH, Gottdiener J, McFann K, Katz R, Kestenbaum B, de Boer IH, Sarnak M, Shlipak MG, Mukamal KJ, et al. Fibroblast growth factor 23, left ventricular mass, and left ventricular hypertrophy in community-dwelling older adults. Atherosclerosis. 2013  ;231(1):114-9.

Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, B?zková P, Fornage M, et al. Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet. 2013  ;93(4):661-71.

Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ. Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet. 2013  ;22(1):184-201.

Hamidovic A, Goodloe RJ, Young TR, Styn MA, Mukamal KJ, Choquet H, Kasberger JL, Buxbaum SG, Papanicolaou GJ, White W, et al. Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites. J Clin Psychopharmacol. 2013  ;33(2):206-10.

Sim X, Jensen RA, M Ikram K, Cotch MFrances, Li X, Macgregor S, Xie J, Smith AVernon, Boerwinkle E, Mitchell P, et al. Genetic loci for retinal arteriolar microcirculation. PLoS One. 2013  ;8(6):e65804.

Fesinmeyer MD, North KE, Ritchie MD, Lim U, Franceschini N, Wilkens LR, Gross MD, B?zková P, Glenn K, P Quibrera M, et al. Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring). 2013  ;21(4):835-46.

Fesinmeyer MD, Meigs JB, North KE, Schumacher FR, B?zková P, Franceschini N, Haessler J, Goodloe R, Spencer KL, Voruganti VSaroja, et al. Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. BMC Med Genet. 2013  ;14:98.

Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013  ;22(16):3381-93.

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013  ;45(2):145-54.

Liu C-T, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013  ;9(8):e1003681.

Tang W, Teichert M, Chasman DI, Heit JA, Morange P-E, Li G, Pankratz N, Leebeek FW, Paré G, de Andrade M, et al. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Genet Epidemiol. 2013  ;37(5):512-521.

H Y Wu J, Lemaitre RN, Manichaikul A, Guan W, Tanaka T, Foy M, Kabagambe EK, Djoussé L, Siscovick D, Fretts AM, et al. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu. Circ Cardiovasc Genet. 2013  ;6(2):171-83.

Fox ER, Musani SK, Barbalic M, Lin H, Yu B, Ogunyankin KO, Smith NL, Kutlar A, Glazer NL, Post WS, et al. Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study. Circ Cardiovasc Genet. 2013  ;6(1):37-46.

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013  ;73(7):667-78.

Perry JRB, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, et al. A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013  ;22(7):1465-72.

Jensen RA, Sim X, Li X, Cotch MFrances, M Ikram K, Holliday EG, Eiriksdottir G, Harris TB, Jonasson F, Klein BEK, et al. Genome-wide association study of retinopathy in individuals without diabetes. PLoS One. 2013  ;8(2):e54232.

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013  ;45(5):501-12.

Hruby A, Ngwa JS, Renstrom F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T, et al. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr. 2013  ;143(3):345-53.

Odden MC, Tager IB, Gansevoort RT, Bakker SJL, Fried LF, Newman AB, Katz R, Satterfield S, Harris TB, Sarnak MJ, et al. Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study. Ann Epidemiol. 2013  ;23(3):106-11.

Hoed Mden, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013  ;45(6):621-31.

Tehrani DM, Gardin JM, Yanez D, Hirsch CH, Lloyd-Jones DM, Stein PK, Wong ND. Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: cardiovascular Health Study. Atherosclerosis. 2013  ;231(2):246-51.

Hussein AA, Gottdiener JS, Bartz TM, Sotoodehnia N, DeFilippi C, See V, Deo R, Siscovick D, Stein PK, Lloyd-Jones D. Inflammation and sudden cardiac death in a community-based population of older adults: the Cardiovascular Health Study. Heart Rhythm. 2013  ;10(10):1425-32.

Graff M, Gordon-Larsen P, Lim U, Fowke JH, Love S-A, Fesinmeyer M, Wilkens LR, Vertilus S, Ritchie MD, Prentice RL, et al. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes. 2013  ;62(5):1763-7.

Holliday EG, Smith AV, Cornes BK, Buitendijk GHS, Jensen RA, Sim X, Aspelund T, Aung T, Baird PN, Boerwinkle E, et al. Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One. 2013  ;8(1):e53830.

Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PMW, et al. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013  ;73(1):16-31.

Zhang L, B?zková P, Wassel CL, Roman MJ, North KE, Crawford DC, Boston J, Brown-Gentry KD, Cole SA, Deelman E, et al. Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis. 2013  ;228(2):390-9.

Huffman MD, Berry JD, Ning H, Dyer AR, Garside DB, Cai X, Daviglus ML, Lloyd-Jones DM. Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project. J Am Coll Cardiol. 2013  ;61(14):1510-7.

Rosano C, Chang Y-F, Kuller LH, Guralnik JM, Studenski SA, Aizenstein HJ, Gianaros PJ, Lopez OL, Longstreth WT, Newman AB. Long-term survival in adults 65 years and older with white matter hyperintensity: association with performance on the digit symbol substitution test. Psychosom Med. 2013  ;75(7):624-31.

Glick D, deFilippi CR, Christenson R, Gottdiener JS, Seliger SL. Long-term trajectory of two unique cardiac biomarkers and subsequent left ventricular structural pathology and risk of incident heart failure in community-dwelling older adults at low baseline risk. JACC Heart Fail. 2013  ;1(4):353-360.

Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, C Y Ng M, Adeyemo AA, Allison MA, Bielak LF, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013  ;45(6):690-6.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013  ;45(12):1452-8.

O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AMercier, Köttgen A, Stoudmann C, Teumer A, Kutalik Z, et al. Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet. 2013  ;9(9):e1003796.

Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, Heijer Mden, Freathy RM, et al. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet. 2013  ;9(2):e1003266.

Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013  ;128(12):1310-24.

Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, B?zková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, et al. No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. Hum Genet. 2013  ;132(12):1427-31.

Djoussé L, Benkeser D, Arnold A, Kizer JR, Zieman SJ, Lemaitre RN, Tracy RP, Gottdiener JS, Mozaffarian D, Siscovick DS, et al. Plasma free fatty acids and risk of heart failure: the Cardiovascular Health Study. Circ Heart Fail. 2013  ;6(5):964-9.

Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, B?zková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, et al. Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study. Ann Hum Genet. 2013  ;77(5):416-25.

van Ballegooijen AJ, Visser M, Kestenbaum B, Siscovick DS, de Boer IH, Gottdiener JS, deFilippi CR, Brouwer IA. Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). Am J Cardiol. 2013  ;111(3):418-24.

Carty CL, Spencer KL, Setiawan VW, Fernandez-Rhodes L, Malinowski J, Buyske S, Young A, Jorgensen NW, Cheng I, Carlson CS, et al. Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Reprod. 2013  ;28(6):1695-706.

Chaudhry SI, McAvay G, Chen S, Whitson H, Newman AB, Krumholz HM, Gill TM. Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the Cardiovascular Health Study. J Am Coll Cardiol. 2013  ;61(6):635-42.

Simone B, De Stefano V, Leoncini E, Zacho J, Martinelli I, Emmerich J, Rossi E, Folsom AR, Almawi WY, Scarabin PY, et al. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol. 2013  ;28(8):621-47.

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013  ;9(6):e1003500.

Alonso A, Krijthe BP, Aspelund T, Stepas KA, Pencina MJ, Moser CB, Sinner MF, Sotoodehnia N, Fontes JD, A Janssens CJW, et al. Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: the CHARGE-AF consortium. J Am Heart Assoc. 2013  ;2(2):e000102.

Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, et al. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013  ;9(1):e1003171.

Kizer JR, Benkeser D, Arnold AM, Djoussé L, Zieman SJ, Mukamal KJ, Tracy RP, Mantzoros CS, Siscovick DS, Gottdiener JS, et al. Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults. J Clin Endocrinol Metab. 2013  ;98(1):255-63.

Wu Y, Waite LL, Jackson AU, Sheu WH-H, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, et al. Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet. 2013  ;9(3):e1003379.

Morrison AC, Voorman A, Johnson AD, Liu X, Yu J, Li A, Muzny D, Yu F, Rice K, Zhu C, et al. Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet. 2013  ;45(8):899-901.

London SJ, Gao W, Gharib SA, Hancock DB, Wilk JB, House JS, Gibbs RA, Muzny DM, Lumley T, Franceschini N, et al. ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014  ;7(3):350-8.

M Gore O, Seliger SL, deFilippi CR, Nambi V, Christenson RH, Hashim IA, Hoogeveen RC, Ayers CR, Sun W, McGuire DK, et al. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J Am Coll Cardiol. 2014  ;63(14):1441-8.

Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ. 2014  ;349:g4164.

Mahmoodi BK, Yatsuya H, Matsushita K, Sang Y, Gottesman RF, Astor BC, Woodward M, Longstreth WT, Psaty BM, Shlipak MG, et al. Association of kidney disease measures with ischemic versus hemorrhagic strokes: pooled analyses of 4 prospective community-based cohorts. Stroke. 2014  ;45(7):1925-31.

Cornes BK, Brody JA, Nikpoor N, Morrison AC, Chu H, Ahn BSoo, Wang S, Dauriz M, Barzilay JI, Dupuis J, et al. Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014  ;7(3):374-382.

Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014  ;94(2):223-32.

Bis JC, DeStefano A, Liu X, Brody JA, Choi SHoan, Verhaaren BFJ, Debette S, Ikram AM, Shahar E, Butler KR, et al. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014  ;9(6):e99798.

Sinner MF, Stepas KA, Moser CB, Krijthe BP, Aspelund T, Sotoodehnia N, Fontes JD, A Janssens CJW, Kronmal RA, Magnani JW, et al. B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies. Europace. 2014  ;16(10):1426-33.

van Leeuwen EM, Smouter FAS, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, et al. The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels. PLoS One. 2014  ;9(10):e109290.

Rosenberg MA, Maziarz M, Tan AY, Glazer NL, Zieman SJ, Kizer JR, Ix JH, Djoussé L, Siscovick DS, Heckbert SR, et al. Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS). Am Heart J. 2014  ;167(5):723-8.e2.

Bots ML, Groenewegen KA, Anderson TJ, Britton AR, Dekker JM, Engström G, Evans GW, de Graaf J, Grobbee DE, Hedblad B, et al. Common carotid intima-media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE-IMT collaboration. Hypertension. 2014  ;63(6):1173-81.

Lemaitre RN, Johnson CO, Hesselson S, Sotoodehnia N, Sotoodhenia N, McKnight B, Sitlani CM, Rea TD, King IB, Kwok P-Y, et al. Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Heart Rhythm. 2014  ;11(3):471-7.

Wilkins JT, Ning H, Stone NJ, Criqui MH, Zhao L, Greenland P, Lloyd-Jones DM. Coronary heart disease risks associated with high levels of HDL cholesterol. J Am Heart Assoc. 2014  ;3(2):e000519.

Coresh J, Turin TChowdhury, Matsushita K, Sang Y, Ballew SH, Appel LJ, Arima H, Chadban SJ, Cirillo M, Djurdjev O, et al. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA. 2014  ;311(24):2518-2531.

Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Chen Y-DIda, de Craen AJM, Eijgelsheim M, et al. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Pharmacogenomics J. 2014  ;14(1):6-13.

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang M-L, Zhang Y, et al. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am J Hum Genet. 2014  ;95(1):49-65.

Nyquist PA, Bilgel MS, Gottesman R, Yanek LR, Moy TF, Becker LC, Cuzzocreo J, Prince J, Yousem DM, Becker DM, et al. Extreme deep white matter hyperintensity volumes are associated with African American race. Cerebrovasc Dis. 2014  ;37(4):244-50.

Garimella PS, Ix JH, Katz R, Chonchol MB, Kestenbaum BR, de Boer IH, Siscovick DS, Shastri S, Hiramoto JS, Shlipak MG, et al. Fibroblast growth factor 23, the ankle-brachial index, and incident peripheral artery disease in the Cardiovascular Health Study. Atherosclerosis. 2014  ;233(1):91-6.

Brown JR, Katz R, Ix JH, de Boer IH, Siscovick DS, Grams ME, Shlipak M, Sarnak MJ. Fibroblast growth factor-23 and the long-term risk of hospital-associated AKI among community-dwelling older individuals. Clin J Am Soc Nephrol. 2014  ;9(2):239-46.

Agarwal I, Glazer NL, Barasch E, Biggs ML, Djoussé L, Fitzpatrick AL, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, et al. Fibrosis-related biomarkers and incident cardiovascular disease in older adults: the cardiovascular health study. Circ Arrhythm Electrophysiol. 2014  ;7(4):583-9.

Agarwal I, Glazer NL, Barasch E, Biggs ML, Djoussé L, Fitzpatrick AL, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, et al. Fibrosis-related biomarkers and risk of total and cause-specific mortality: the cardiovascular health study. Am J Epidemiol. 2014  ;179(11):1331-9.

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renstrom F, Lin X, et al. FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet. 2014  ;23(25):6961-72.

Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, et al. Gender and telomere length: systematic review and meta-analysis. Exp Gerontol. 2014  ;51:15-27.

Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang S-J, Sijbrands E, Smith AV, et al. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. Am J Hum Genet. 2014  ;95(1):24-38.

Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, et al. Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014  ;23(9):2498-510.

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014  ;46(8):826-36.

Restrepo NA, Spencer KL, Goodloe R, Garrett TA, Heiss G, B?zková P, Jorgensen N, Jensen RA, Matise TC, Hindorff LA, et al. Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. Invest Ophthalmol Vis Sci. 2014  ;55(10):6839-50.

Bihlmeyer NA, Brody JA, Smith AVernon, Lunetta KL, Nalls M, Smith JA, Tanaka T, Davies G, Yu L, Mirza SSaeed, et al. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014  ;15:159.

Escott-Price V, Bellenguez C, San Wang L-, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One. 2014  ;9(6):e94661.

Loth DW, Artigas MSoler, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AVernon, Duan Q, Oldmeadow C, et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet. 2014  ;46(7):669-77.

Huang J, Huffman JE, Yamakuchi M, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët D-A, Chen W-M, Smith NL, et al. Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol. 2014  ;34(5):1093-101.

Lüneburg N, Lieb W, Zeller T, Chen M-H, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, et al. Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet. 2014  ;7(6):864-72.

Guan W, Steffen BT, Lemaitre RN, H Y Wu J, Tanaka T, Manichaikul A, Foy M, Rich SS, Wang L, Nettleton JA, et al. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet. 2014  ;7(3):321-331.

Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Seshasai SRao Kondap, Thompson A, Sarwar N, Willeit P, et al. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA. 2014  ;311(12):1225-33.

Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA, Rawal R, Roef GL, Plantinga TS, Vermeulen SH, et al. Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genet. 2014  ;10(2):e1004123.

Jensen PN, Gronroos NN, Chen LY, Folsom AR, deFilippi C, Heckbert SR, Alonso A. Incidence of and risk factors for sick sinus syndrome in the general population. J Am Coll Cardiol. 2014  ;64(6):531-8.

Sinner MF, Tucker NR, Lunetta KL, Ozaki K, J Smith G, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, et al. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014  ;130(15):1225-35.

Ellis J, Lange EM, Li J, Dupuis J, Baumert J, Walston JD, Keating BJ, Durda P, Fox ER, Palmer CD, et al. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans. Hum Genet. 2014  ;133(8):985-95.

Tang W, Kowgier M, Loth DW, Artigas MSoler, Joubert BR, Hodge E, Gharib SA, Smith AV, Ruczinski I, Gudnason V, et al. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS One. 2014  ;9(7):e100776.

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014  ;46(9):989-93.

Gray KE, Schiff MA, Fitzpatrick AL, Kimura M, Aviv A, Starr JR. Leukocyte telomere length and age at menopause. Epidemiology. 2014  ;25(1):139-46.

Crosby J, Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y, Tang Z-Z, Zhang H, Hindy G, et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014  ;371(1):22-31.

Waterworth DM, Li L, Scott R, Warren L, Gillson C, Aponte J, Sarov-Blat L, Sprecher D, Dupuis J, Reiner A, et al. A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker. J Am Heart Assoc. 2014  ;3(4).

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, et al. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology. 2014  ;83(8):678-85.

C Y Ng M, Shriner D, Chen BH, Li J, Chen W-M, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014  ;10(8):e1004517.

Chen CTL, Liu C-T, Chen GK, Andrews JS, Arnold AM, Dreyfus J, Franceschini N, Garcia ME, Kerr KF, Li G, et al. Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet. 2014  ;23(12):3327-42.

Garg PK, Biggs ML, Carnethon M, Ix JH, Criqui MH, Britton KA, Djoussé L, Sutton-Tyrrell K, Newman AB, Cushman M, et al. Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study. Hypertension. 2014  ;63(2):413-9.

Kocarnik JM, Pendergrass SA, Carty CL, Pankow JS, Schumacher FR, Cheng I, Durda P, Ambite JLuis, Deelman E, Cook NR, et al. Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study. Circ Cardiovasc Genet. 2014  ;7(2):178-88.

Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, et al. No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. PLoS One. 2014  ;9(12):e111156.

Lubitz SA, Lunetta KL, Lin H, Arking DE, Trompet S, Li G, Krijthe BP, Chasman DI, Barnard J, Kleber ME, et al. Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J Am Coll Cardiol. 2014  ;63(12):1200-10.

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, et al. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014  ;5:5068.

Braskie MN, Boyle CP, Rajagopalan P, Gutman BA, Toga AW, Raji CA, Tracy RP, Kuller LH, Becker JT, Lopez OL, et al. Physical activity, inflammation, and volume of the aging brain. Neuroscience. 2014  ;273:199-209.

Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SHoan, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ, et al. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke. 2014  ;45(2):403-12.

de Weerd M, Greving JP, Hedblad B, Lorenz MW, Mathiesen EB, O'Leary DH, Rosvall M, Sitzer M, de Borst GJan, Buskens E, et al. Prediction of asymptomatic carotid artery stenosis in the general population: identification of high-risk groups. Stroke. 2014  ;45(8):2366-71.

Kim DHyun, Grodstein F, Newman AB, Chaves PHM, Odden MC, Klein R, Sarnak MJ, Patel KV, Lipsitz LA. Prognostic implications of microvascular and macrovascular abnormalities in older adults: cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2014  ;69(12):1495-502.

Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JPA, Peters U, Robinson JG, Sucheston LE, et al. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Hum Mol Genet. 2014  ;23(8):1957-63.

Raji CA, Erickson KI, Lopez OL, Kuller LH, H Gach M, Thompson PM, Riverol M, Becker JT. Regular fish consumption and age-related brain gray matter loss. Am J Prev Med. 2014  ;47(4):444-51.

Karas MG, Benkeser D, Arnold AM, Bartz TM, Djoussé L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, et al. Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults ?65 years of age (from the Cardiovascular Health study). Am J Cardiol. 2014  ;113(2):328-34.

Wen CPang, Matsushita K, Coresh J, Iseki K, Islam M, Katz R, McClellan W, Peralta CA, Wang H, de Zeeuw D, et al. Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar. Kidney Int. 2014  ;86(4):819-27.

Lovasi GS, Richardson JM, Rodriguez CJ, Kop WJ, Ahmed A, Brown AF, Greenlee H, Siscovick DS. Residential relocation by older adults in response to incident cardiovascular health events: a case-crossover analysis. J Environ Public Health. 2014  ;2014:951971.

Wang T, Zhou B, Guo T, Bidlingmaier M, Wallaschofski H, Teumer A, Vasan RS, Kaplan RC. A robust method for genome-wide association meta-analysis with the application to circulating insulin-like growth factor I concentrations. Genet Epidemiol. 2014  ;38(2):162-71.

Ferket BS, van Kempen BJH, Wieberdink RG, Steyerberg EW, Koudstaal PJ, Hofman A, Shahar E, Gottesman RF, Rosamond W, Kizer JR, et al. Separate prediction of intracerebral hemorrhage and ischemic stroke. Neurology. 2014  ;82(20):1804-12.

Morrison AC, Bis JC, Hwang S-J, Ehret GB, Lumley T, Rice K, Muzny D, Gibbs RA, Boerwinkle E, Psaty BM, et al. Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. PLoS One. 2014  ;9(10):e109155.

Liu C-T, Young KL, Brody JA, Olden M, Wojczynski MK, Heard-Costa N, Li G, Morrison AC, Muzny D, Gibbs RA, et al. Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014  ;7(3):344-9.

Bis JC, White CC, Franceschini N, Brody J, Zhang X, Muzny D, Santibanez J, Gibbs R, Liu X, Lin H, et al. Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014  ;7(3):359-64.

Magnani JW, Brody JA, Prins BP, Arking DE, Lin H, Yin X, Liu C-T, Morrison AC, Zhang F, Spector TD, et al. Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Circ Cardiovasc Genet. 2014  ;7(3):365-73.

Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, et al. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014  ;45(1):24-36.

Tare A, Lane JM, Cade BE, Grant SFA, Chen T-H, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, et al. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014  ;57(2):339-46.

Lin H, Wang M, Brody JA, Bis JC, Dupuis J, Lumley T, McKnight B, Rice KM, Sitlani CM, Reid JG, et al. Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014  ;7(3):335-43.

Garin MC, Arnold AM, Lee JS, Tracy RP, Cappola AR. Subclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study. J Clin Endocrinol Metab. 2014  ;99(4):1220-6.

Garin MC, Arnold AM, Lee JS, Robbins J, Cappola AR. Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the cardiovascular health study. J Clin Endocrinol Metab. 2014  ;99(8):2657-64.

Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, et al. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2014  ;11(3):452-7.

Roberts JD, Dewland TA, Longoria J, Fitzpatrick AL, Ziv E, Hu D, Lin J, Glidden DV, Psaty BM, Burchard EG, et al. Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging. Circ Arrhythm Electrophysiol. 2014  ;7(6):1026-32.

Collet T-H, Bauer DC, Cappola AR, Asvold BO, Weiler S, Vittinghoff E, Gussekloo J, Bremner A, Elzen WPJ den, Maciel RMB, et al. Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: an individual participant data analysis. J Clin Endocrinol Metab. 2014  ;99(9):3353-62.

Keller MF, Reiner AP, Okada Y, van Rooij FJA, Johnson AD, Chen M-H, Smith AV, Morris AP, Tanaka T, Ferrucci L, et al. Trans-ethnic meta-analysis of white blood cell phenotypes. Hum Mol Genet. 2014  ;23(25):6944-60.

Gardin JM, Bartz TM, Polak JF, O'Leary DH, Wong ND. What do carotid intima-media thickness and plaque add to the prediction of stroke and cardiovascular disease risk in older adults? The cardiovascular health study. J Am Soc Echocardiogr. 2014  ;27(9):998-1005.e2.

Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang Z-Z, Bizon C, Lange EM, Smith JD, Turner EH, et al. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014  ;94(2):233-45.

Kamel H, Bartz TM, Longstreth WT, Okin PM, Thacker EL, Patton KK, Stein PK, Gottesman RF, Heckbert SR, Kronmal RA, et al. Association between left atrial abnormality on ECG and vascular brain injury on MRI in the Cardiovascular Health Study. Stroke. 2015  ;46(3):711-6.

Hansen JG, Gao W, Dupuis J, O'Connor GT, Tang W, Kowgier M, Sood A, Gharib SA, Palmer LJ, Fornage M, et al. Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study. Respir Res. 2015  ;16:81.

Chauhan G, Adams HHH, Bis JC, Weinstein G, Yu L, Töglhofer AMaria, Smith AVernon, van der Lee SJ, Gottesman RF, Thomson R, et al. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiol Aging. 2015  ;36(4):1765.e7-16.

Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, O'Keeffe LM, Gao P, Wood AM, Burgess S, et al. Association of Cardiometabolic Multimorbidity With Mortality. JAMA. 2015  ;314(1):52-60.

Schick UM, Auer PL, Bis JC, Lin H, Wei P, Pankratz N, Lange LA, Brody J, Stitziel NO, Kim DS, et al. Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Hum Mol Genet. 2015  ;24(2):559-71.

Fink HA, B?zková P, Garimella PS, Mukamal KJ, Cauley JA, Kizer JR, Barzilay JI, Jalal DI, Ix JH. Association of Fetuin-A With Incident Fractures in Community-Dwelling Older Adults: The Cardiovascular Health Study. J Bone Miner Res. 2015  ;30(8):1394-402.

Ashar FN, Moes A, Moore AZ, Grove ML, Chaves PHM, Coresh J, Newman AB, Matteini AM, Bandeen-Roche K, Boerwinkle E, et al. Association of mitochondrial DNA levels with frailty and all-cause mortality. J Mol Med (Berl). 2015  ;93(2):177-186.

Yu B, Li AH, Muzny D, Veeraraghavan N, de Vries PS, Bis JC, Musani SK, Alexander D, Morrison AC, Franco OH, et al. Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease. Circ Cardiovasc Genet. 2015  ;8(2):351-5.

Agarwal I, Glazer NL, Barasch E, Djoussé L, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, Siscovick DS, King GL, et al. Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study. Metabolism. 2015  ;64(10):1316-23.

Murad K, Goff DC, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW. Burden of Comorbidities and Functional and Cognitive Impairments in Elderly Patients at the Initial Diagnosis of Heart Failure and Their Impact on Total Mortality: The Cardiovascular Health Study. JACC Heart Fail. 2015  ;3(7):542-50.

Waheed S, Chaves PHM, Gardin JM, Cao JJane. Cardiovascular and Mortality Outcomes in the Elderly With Impaired Cardiac and Pulmonary Function: The Cardiovascular Health Study (CHS). J Am Heart Assoc. 2015  ;4(12).

Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IPanagiota, Varga TV, Frazier-Wood AC, Houston DK, et al. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015  ;102(5):1266-78.

Bis JC, Sitlani C, Irvin R, Avery CL, Smith AVernon, Sun F, Evans DS, Musani SK, Li X, Trompet S, et al. Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium. PLoS One. 2015  ;10(10):e0140496.

Do R, Stitziel NO, Won H-H, Jørgensen ABerg, Duga S, Merlini PAngelica, Kiezun A, Farrall M, Goel A, Zuk O, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015  ;518(7537):102-6.

Agarwal I, Arnold A, Glazer NL, Barasch E, Djoussé L, Fitzpatrick AL, Gottdiener JS, Ix JH, Jensen RA, Kizer JR, et al. Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study. Atherosclerosis. 2015  ;239(2):539-46.

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, et al. Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015  ;24(16):4728-38.

Tang W, Cushman M, Green D, Rich SS, Lange LA, Yang Q, Tracy RP, Tofler GH, Basu S, Wilson JG, et al. Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans. Am J Hematol. 2015  ;90(6):534-40.

Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, de Jong JCKiefte-, Lamon-Fava S, et al. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015  ;38(8):1456-66.

Lopez LM, W Hill D, Harris SE, Hernandez MValdes, Maniega SMunoz, Bastin ME, Bailey E, Smith C, McBride M, McClure J, et al. Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke. 2015  ;46(2):341-7.

Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015  ;20(2):183-92.

Lemaitre RN, King IB, Kabagambe EK, H Y Wu J, McKnight B, Manichaikul A, Guan W, Sun Q, Chasman DI, Foy M, et al. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. J Lipid Res. 2015  ;56(1):176-84.

van Leeuwen EM, Karssen LC, Deelen J, Isaacs A, Medina-Gómez C, Mbarek H, Kanterakis A, Trompet S, Postmus I, Verweij N, et al. Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nat Commun. 2015  ;6:6065.

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, et al. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry. 2015  ;20(5):647-56.

Debette S, Verbaas CAIbrahim, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, et al. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015  ;77(8):749-63.

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015  ;70(1):110-8.

Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, et al. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015  ;101(1):135-43.

Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JEL, Shah T, Sofat R, Stender S, Johnson PCD, Scott RA, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015  ;385(9965):351-61.

Gharib SA, Loth DW, Artigas MSoler, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M'en, Hancock DB, Tang W, et al. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015  ;24(23):6836-48.

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert M-F, Raghavan S, Lipovich L, et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun. 2015  ;6:5897.

Hoang K, Zhao Y, Gardin JM, Carnethon M, Mukamal K, Yanez D, Wong ND. LV Mass as a Predictor of CVD Events in Older Adults With and Without Metabolic Syndrome and Diabetes. JACC Cardiovasc Imaging. 2015  ;8(9):1007-15.

Holmes MV, Asselbergs FW, Palmer TM, Drenos F, Lanktree MB, Nelson CP, Dale CE, Padmanabhan S, Finan C, Swerdlow DI, et al. Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J. 2015  ;36(9):539-50.

Germain M, Chasman DI, de Haan H, Tang W, Lindström S, Weng L-C, de Andrade M, de Visser MCH, Wiggins KL, Suchon P, et al. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. Am J Hum Genet. 2015  ;96(4):532-42.

Carty CL, Keene KL, Cheng Y-C, Meschia JF, Chen W-M, Nalls M, Bis JC, Kittner SJ, Rich SS, Tajuddin S, et al. Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. Stroke. 2015  ;46(8):2063-8.

Grams ME, Sang Y, Ballew SH, Gansevoort RT, Kimm H, Kovesdy CP, Naimark D, Oien C, Smith DH, Coresh J, et al. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury. Am J Kidney Dis. 2015  ;66(4):591-601.

James MT, Grams ME, Woodward M, C Elley R, Green JA, Wheeler DC, de Jong P, Gansevoort RT, Levey AS, Warnock DG, et al. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury. Am J Kidney Dis. 2015  ;66(4):602-12.

Kim DHyun, Grodstein F, Newman AB, Chaves PHM, Odden MC, Klein R, Sarnak MJ, Lipsitz LA. Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study. J Am Geriatr Soc. 2015  ;63(9):1886-93.

Verhaaren BFJ, Debette S, Bis JC, Smith JA, M Ikram K, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, et al. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet. 2015  ;8(2):398-409.

Gottlieb DJ, Hek K, Chen T-H, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, et al. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry. 2015  ;20(10):1232-9.

Seliger SL, de Lemos J, Neeland IJ, Christenson R, Gottdiener J, Drazner MH, Berry J, Sorkin J, DeFilippi C. Older Adults, "Malignant" Left Ventricular Hypertrophy, and Associated Cardiac-Specific Biomarker Phenotypes to Identify the Differential Risk of New-Onset Reduced Versus Preserved Ejection Fraction Heart Failure: CHS (Cardiovascular Health Study). JACC Heart Fail. 2015  ;3(6):445-55.

Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, H Gach M, Longstreth WT, Teverovskiy L, Kuller LH, Carmichael OT, et al. Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging. 2015  ;36 Suppl 1:S194-S202.

Yu F, Lu J, Liu X, Gazave E, Chang D, Raj S, Hunter-Zinck H, Blekhman R, Arbiza L, Van Hout C, et al. Population genomic analysis of 962 whole genome sequences of humans reveals natural selection in non-coding regions. PLoS One. 2015  ;10(3):e0121644.

Parikh RH, Seliger SL, de Lemos J, Nambi V, Christenson R, Ayers C, Sun W, Gottdiener JS, Kuller LH, Ballantyne C, et al. Prognostic Significance of High-Sensitivity Cardiac Troponin T Concentrations between the Limit of Blank and Limit of Detection in Community-Dwelling Adults: A Metaanalysis. Clin Chem. 2015  ;61(12):1524-31.

Gijsberts CM, Groenewegen KA, Hoefer IE, Eijkemans MJC, Asselbergs FW, Anderson TJ, Britton AR, Dekker JM, Engström G, Evans GW, et al. Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. PLoS One. 2015  ;10(7):e0132321.

Huffman JE, de Vries PS, Morrison AC, Sabater-Lleal M, Kacprowski T, Auer PL, Brody JA, Chasman DI, Chen M-H, Guo X, et al. Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood. 2015  ;126(11):e19-29.

Riverol M, Becker JT, Lopez OL, Raji CA, Thompson PM, Carmichael OT, H Gach M, Longstreth WT, Fried L, Tracy RP, et al. Relationship between Systemic and Cerebral Vascular Disease and Brain Structure Integrity in Normal Elderly Individuals. J Alzheimers Dis. 2015  ;44(1):319-28.

Khan H, Kunutsor S, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Bibbins-Domingo K, Kauhanen J, Gheorghiade M, Fonarow GC, et al. Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis. J Am Heart Assoc. 2015  ;4(1):e001364.

Hussein AA, Bartz TM, Gottdiener JS, Sotoodehnia N, Heckbert SR, Lloyd-Jones D, Kizer JR, Christenson R, Wazni O, DeFilippi C. Serial measures of cardiac troponin T levels by a highly sensitive assay and incident atrial fibrillation in a prospective cohort of ambulatory older adults. Heart Rhythm. 2015  ;12(5):879-85.

Chaker L, Baumgartner C, Elzen WPJ den, Ikram AM, Blum MR, Collet T-H, Bakker SJL, Dehghan A, Drechsler C, Luben RN, et al. Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2015  ;100(6):2181-91.

Blum MR, Bauer DC, Collet T-H, Fink HA, Cappola AR, da Costa BR, Wirth CD, Peeters RP, Asvold BO, Elzen WPJ den, et al. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA. 2015  ;313(20):2055-65.

Asvold BO, Vatten LJ, Bjøro T, Bauer DC, Bremner A, Cappola AR, Ceresini G, Elzen WPJ den, Ferrucci L, Franco OH, et al. Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts. JAMA Intern Med. 2015  ;175(6):1037-47.

Garimella PS, Biggs ML, Katz R, Ix JH, Bennett MR, Devarajan P, Kestenbaum BR, Siscovick DS, Jensen MK, Shlipak MG, et al. Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults. Kidney Int. 2015  ;88(5):1126-34.

Ix JH, Biggs ML, Mukamal K, Djoussé L, Siscovick D, Tracy R, Katz R, Delaney JA, Chaves P, Rifkin DE, et al. Urine Collagen Fragments and CKD Progression-The Cardiovascular Health Study. J Am Soc Nephrol. 2015  ;26(10):2494-503.

Dukes JW, Dewland TA, Vittinghoff E, Mandyam MC, Heckbert SR, Siscovick DS, Stein PK, Psaty BM, Sotoodehnia N, Gottdiener JS, et al. Ventricular Ectopy as a Predictor of Heart Failure and Death. J Am Coll Cardiol. 2015  ;66(2):101-9.

Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BFJ, Wolf C, et al. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences. Stroke. 2015  ;46(11):3048-57.

Alshawabkeh LI, Yee LM, Gardin JM, Gottdiener JS, Odden MC, Bartz TM, Arnold AM, Mukamal KJ, Wallace RB. Years of able life in older persons--the role of cardiovascular imaging and biomarkers: the Cardiovascular Health Study. J Am Heart Assoc. 2015  ;4(4).

Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, Yakoob MY, Chiuve SE, L. Cruz D, Frazier-Wood AC, et al. -3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. JAMA Intern Med. 2016  ;176:1155?1166.

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Leach IMateo, Eijgelsheim M, Sotoodehnia N, et al. 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 2016  ;68(13):1435-48.

Bortnick AE, Bartz TM, Ix JH, Chonchol M, Reiner A, Cushman M, Owens D, Barasch E, Siscovick DS, Gottdiener JS, et al. Association of inflammatory, lipid and mineral markers with cardiac calcification in older adults. Heart. 2016  .

Spahillari A, Mukamal KJ, DeFilippi C, Kizer JR, Gottdiener JS, Djoussé L, Lyles MF, Bartz TM, Murthy VL, Shah RV. The association of lean and fat mass with all-cause mortality in older adults: The Cardiovascular Health Study. Nutr Metab Cardiovasc Dis. 2016  .

Willems SM, Cornes BK, Brody JA, Morrison AC, Lipovich L, Dauriz M, Chen Y, Liu C-T, Rybin DV, Gibbs RA, et al. Association of the IGF1 gene with fasting insulin levels. Eur J Hum Genet. 2016  ;24(9):1337-43.

Kim F, Biggs ML, Kizer JR, Brutsaert EF, de Fillipi C, Newman AB, Kronmal RA, Tracy RP, Gottdiener JS, Djoussé L, et al. Brain natriuretic peptide and insulin resistance in older adults. Diabet Med. 2016  .

Zhao Y, Delaney JA, Quek RGW, Gardin JM, Hirsch CH, Gandra SR, Wong ND. Cardiovascular Disease, Mortality Risk, and Healthcare Costs by Lipoprotein(a) Levels According to Low-density Lipoprotein Cholesterol Levels in Older High-risk Adults. Clin Cardiol. 2016  ;39(7):413-20.

Gilsanz P, Kubzansky LD, Tchetgen EJTchetgen, Wang Q, Kawachi I, Patton KK, Fitzpatrick AL, Kop WJ, Longstreth WT, M Glymour M. Changes in Depressive Symptoms and Subsequent Risk of Stroke in the Cardiovascular Health Study. Stroke. 2016  .

Cade BE, Gottlieb DJ, Lauderdale DS, Bennett DA, Buchman AS, Buxbaum SG, De Jager PL, Evans DS, Fulop T, Gharib SA, et al. Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet. 2016  ;25(1):167-79.

Khera AV, Won H-H, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, et al. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016  ;67(22):2578-89.

J Smith G, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, et al. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. PLoS Genet. 2016  ;12(5):e1006034.

Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai P-C, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, et al. A DNA methylation biomarker of alcohol consumption. Mol Psychiatry. 2016  .

Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016  ;17(1):255.

Konety SH, Koene RJ, Norby FL, Wilsdon T, Alonso A, Siscovick D, Sotoodehnia N, Gottdiener J, Fox ER, Chen LY, et al. Echocardiographic Predictors of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study and Cardiovascular Health Study. Circ Cardiovasc Imaging. 2016  ;9(8).

Sung YJu, Winkler TW, Manning AK, Aschard H, Gudnason V, Harris TB, Smith AV, Boerwinkle E, Brown MR, Morrison AC, et al. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genet Epidemiol. 2016  ;40(5):404-15.

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, et al. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016  ;9(5):436-447.

Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SHoan, et al. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016  ;53(3):921-32.

Chami N, Chen M-H, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, et al. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016  ;99(1):8-21.

Perera S, Patel KV, Rosano C, Rubin SM, Satterfield S, Harris T, Ensrud K, Orwoll E, Lee CG, Chandler JM, et al. Gait Speed Predicts Incident Disability: A Pooled Analysis. J Gerontol A Biol Sci Med Sci. 2016  ;71(1):63-71.

Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, et al. {Gene-gene Interaction Analyses for Atrial Fibrillation. Sci Rep. 2016  ;6:35371.

Wang S, Zhao JH, An P, Guo X, Jensen RA, Marten J, Huffman JE, Meidtner K, Boeing H, Campbell A, et al. General Framework for Meta-Analysis of Haplotype Association Tests. Genet Epidemiol. 2016  ;40(3):244-52.

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, et al. {Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016  ;7:10023.

Amin N, Allebrandt KV, van der Spek A, Müller-Myhsok B, Hek K, Teder-Laving M, Hayward C, Esko T, van Mill JG, Mbarek H, et al. Genetic variants in RBFOX3 are associated with sleep latency. Eur J Hum Genet. 2016  ;24(10):1488-95.

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, et al. {The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016  ;48:1171?1184.

Cheng Y-C, Stanne TM, Giese A-K, Ho WKee, Traylor M, Amouyel P, Holliday EG, Malik R, Xu H, Kittner SJ, et al. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke. 2016  ;47(2):307-16.

Dehghan A, Bis JC, White CC, Smith AVernon, Morrison AC, Cupples AL, Trompet S, Chasman DI, Lumley T, Völker U, et al. Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. PLoS One. 2016  ;11(3):e0144997.

Taylor KC, Evans DS, Edwards DRVelez, Edwards TL, Sofer T, Li G, Liu Y, Franceschini N, Jackson RD, Giri A, et al. A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women. Bone Rep. 2016  ;5:233-242.

Walford GA, Gustafsson S, Rybin D, Stan?áková A, Chen H, Liu C-T, Hong J, Jensen RA, Rice K, Morris AP, et al. Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes. 2016  ;65(10):3200-11.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L, Cappola A, et al. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016  ;15(5):811-24.

Waks JW, Sitlani CM, Soliman EZ, Kabir M, Ghafoori E, Biggs ML, Henrikson CA, Sotoodehnia N, Biering-Sørensen T, Agarwal SK, et al. Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies. Circulation. 2016  ;133(23):2222-34.

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou W-C, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, et al. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016  ;15(5):792-800.

Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, et al. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry. 2016  ;21(2):189-97.

Huang Z, Rustagi N, Veeraraghavan N, Carroll A, Gibbs R, Boerwinkle E, Venkata MGorentla, Yu F. A hybrid computational strategy to address WGS variant analysis in >5000 samples. BMC Bioinformatics. 2016  ;17(1):361.

Roberts JD, Dewland TA, Glidden DV, Hoffmann TJ, Arking DE, Chen LY, Psaty BM, Olgin JE, Alonso A, Heckbert SR, et al. Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation. Am Heart J. 2016  ;175:9-17.

Willeit P, Thompson SG, Agewall S, Bergström G, Bickel H, Catapano AL, Chien K-L, de Groot E, Empana J-P, Etgen T, et al. Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration. Eur J Prev Cardiol. 2016  ;23(2):194-205.

Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W, Wang L, et al. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016  ;103(2):567-78.

Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, et al. KLB is associated with alcohol drinking, and its gene product ?-Klotho is necessary for FGF21 regulation of alcohol preference. Proc Natl Acad Sci U S A. 2016  ;113(50):14372-14377.

Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, W Hill D, Kacprowski T, Li J, Lyytikäinen L-P, et al. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016  ;99(1):22-39.

Floyd JS, Sitlani CM, Avery CL, Noordam R, Li X, Smith AV, Gogarten SM, Li J, Broer L, Evans DS, et al. Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. Pharmacogenomics J. 2016  .

Garg PK, Arnold AM, Stukovsky KDHinckley, Koro C, Jenny NS, Mukamal KJ, Criqui MH, Furberg CD, Newman AB, Cushman M. Lipoprotein-Associated Phospholipase A2 and Incident Peripheral Arterial Disease in Older Adults: The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2016  ;36(4):750-6.

Brutsaert EF, Biggs ML, Delaney JA, Djoussé L, Gottdiener JS, Ix JH, Kim F, Mukamal KJ, Siscovick DS, Tracy RP, et al. Longitudinal assessment of N-terminal pro-B-type natriuretic peptide and risk of diabetes in older adults: The cardiovascular health study. Metabolism. 2016  ;65(10):1489-97.

Raji CA, Merrill DA, Eyre H, Mallam S, Torosyan N, Erickson KI, Lopez OL, Becker JT, Carmichael OT, H Gach M, et al. Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study. J Alzheimers Dis. 2016  ;52(2):719-29.

Karas MG, Yee LM, Biggs ML, Djoussé L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Gottdiener JS, Rosenberg MA, et al. Measures of Body Size and Composition and Risk of Incident Atrial Fibrillation in Older People: The Cardiovascular Health Study. Am J Epidemiol. 2016  ;183(11):998-1007.

Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016  ;48(10):1162-70.

de Vries PS, Chasman DI, Sabater-Lleal M, Chen M-H, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, et al. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Hum Mol Genet. 2016  ;25(2):358-70.

van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, et al. Meta-analysis of 49?549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet. 2016  ;53(7):441-9.

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, et al. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J Med Genet. 2016  ;53(12):835-845.

Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang S-J, Isaacs A, et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016  .

Willeit P, Kaptoge S, Welsh P, Butterworth A, Chowdhury, iv R, Spackman S, Pennells L, Gao P, Burgess S, Freitag D, et al. Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. Lancet Diabetes Endocrinol. 2016  ;4(10):840-9.

Rosso AL, Flatt JD, Carlson MC, Lovasi GS, Rosano C, Brown AF, Matthews KA, Gianaros PJ. Neighborhood Socioeconomic Status and Cognitive Function in Late Life. Am J Epidemiol. 2016  ;183(12):1088-97.

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. 2016  ;21(1):108-17.

Jensen RA, Sim X, Smith AVernon, Li X, Jakobsdottir J, Cheng C-Y, Brody JA, Cotch MFrances, McKnight B, Klein R, et al. Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet. 2016  ;9(1):45-54.

Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Renter?a ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivi?res S, et al. {Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016  ;19:1569?1582.

Eicher JD, Chami N, Kacprowski T, Nomura A, Chen M-H, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, et al. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016  ;99(1):40-55.

Ho JE, Enserro D, Brouwers FP, Kizer JR, Shah SJ, Psaty BM, Bartz TM, Santhanakrishnan R, Lee DS, Chan C, et al. Predicting Heart Failure With Preserved and Reduced Ejection Fraction: The International Collaboration on Heart Failure Subtypes. Circ Heart Fail. 2016  ;9(6).

Ried JS, M JJeff, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat Commun. 2016  ;7:13357.

Folsom AR, Tang W, George KM, Heckbert SR, MacLehose RF, Cushman M, Pankow JS. Prospective study of ?' fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). Thromb Res. 2016  ;139:44-9.

Yu B, Pulit SL, Hwang S-J, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, et al. Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk. Circ Cardiovasc Genet. 2016  ;9(1):64-70.

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, et al. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet. 2016  ;12(10):e1006327.

Olfson E, Saccone NL, Johnson EO, Chen L-S, Culverhouse R, Doheny K, Foltz SM, Fox L, Gogarten SM, Hartz S, et al. Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Mol Psychiatry. 2016  ;21(5):601-7.

Garg PK, Koh WJH, Delaney JA, Halm EA, Hirsch CH, Longstreth WT, Mukamal KJ, Kucharska-Newton A, Polak JF, Curtis L. Risk Factors for Incident Carotid Artery Revascularization among Older Adults: The Cardiovascular Health Study. Cerebrovasc Dis Extra. 2016  ;6(3):129-139.

Parikh RH, Seliger SL, Christenson R, Gottdiener JS, Psaty BM, deFilippi CR. Soluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community-Dwelling Population. J Am Heart Assoc. 2016  ;5(8).

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen L-P, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2016  .

Psaty BM, Delaney JA, Arnold AM, Curtis LH, Fitzpatrick AL, Heckbert SR, McKnight B, Ives D, Gottdiener JS, Kuller LH, et al. Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study. Circulation. 2016  ;133(2):156-64.

Barzilay JI, B??ková P, Fink HA, Cauley JA, Robbins JA, Garimella PS, Jalal DI, Mukamal KJ. Systemic markers of microvascular disease and bone mineral density in older adults : The cardiovascular health study. Osteoporos Int. 2016  ;27(11):3217-3225.

Hsu Y-H, Li G, Liu C-T, Brody JA, Karasik D, Chou W-C, Demissie S, Nandakumar K, Zhou Y, Cheng C-H, et al. Targeted Sequencing of Genome Wide Significant Loci Associated with Bone Mineral Density (BMD) Reveals Significant Novel and Rare Variants: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Hum Mol Genet. 2016  .

Chaker L, Baumgartner C, Elzen WPJ den, Collet T-H, Ikram AM, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies MLP, et al. Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2016  ;101(11):4270-4282.

Liu C-T, Raghavan S, Maruthur N, Kabagambe EKato, Hong J, C Y Ng M, Hivert M-F, Lu Y, An P, Bentley AR, et al. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet. 2016  ;99(1):56-75.

Verweij N, Leach IMateo, Isaacs A, Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen L-P, Barnett P, Wang X, et al. Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram. Hum Mol Genet. 2016  ;25(10):2093-2103.

Garimella PS, Bartz TM, Ix JH, Chonchol M, Shlipak MG, Devarajan P, Bennett MR, Sarnak MJ. Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study. Am J Kidney Dis. 2016  .

Desai CS, Bartz TM, Gottdiener JS, Lloyd-Jones DM, Gardin JM. Usefulness of Left Ventricular Mass and Geometry for Determining 10-Year Prediction of Cardiovascular Disease in Adults Aged >65 Years (from the Cardiovascular Health Study). Am J Cardiol. 2016  ;118(5):684-90.

Lubitz SA, Brody JA, Bihlmeyer NA, Roselli C, Weng L-C, Christophersen IE, Alonso A, Boerwinkle E, Gibbs RA, Bis JC, et al. Whole Exome Sequencing in Atrial Fibrillation. PLoS Genet. 2016  ;12(9):e1006284.

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen M-H, Auer PL, Floyd JS, Huang J, et al. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016  ;99(3):785.

Wu JHY, Marklund M, Imamura F, Tintle N, Korat AVArdisso, de Goede J, Zhou X, Yang WS, Otto MC de Oliv, ger J, et al. 740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol. 2017  ;5:965?974.

Beecham GW, Bis JC, Martin ER, Choi S-H, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, et al. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet. 2017  ;3(5):e194.

Brody JA, Morrison AC, Bis JC, O'Connell JR, Brown MR, Huffman JE, Ames DC, Carroll A, Conomos MP, Gabriel S, et al. Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology. Nat Genet. 2017  ;49(11):1560-1563.

Lindström S, Germain M, Crous-Bou M, Smith EN, Morange P-E, Vlieg Avan Hylcka, de Haan HG, Chasman D, Ridker P, Brody J, et al. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Hum Genet. 2017  ;136(7):897-902.

Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KHazel, Timpson NJ, Evans DM, Willeit P, et al. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol. 2017  ;3(5):636-651.

Yano Y, O'Donnell CJ, Kuller L, Kavousi M, Erbel R, Ning H, D'Agostino R, Newman AB, Nasir K, Hofman A, et al. Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies. JAMA Cardiol. 2017  .

Ashar FN, Zhang Y, Longchamps RJ, Lane J, Moes A, Grove ML, Mychaleckyj JC, Taylor KD, Coresh J, Rotter JI, et al. Association of Mitochondrial DNA Copy Number With Cardiovascular Disease. JAMA Cardiol. 2017  ;2(11):1247-1255.

Haljas K, Amare AT, Alizadeh BZ, Hsu Y-H, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, et al. Bivariate Genome-Wide Association Study of Depressive Symptoms with Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med. 2017  .

Leung LY, Bartz TM, Rice K, Floyd J, Psaty B, Gutierrez J, Longstreth WT, Mukamal KJ. Blood Pressure and Heart Rate Measures Associated With Increased Risk of Covert Brain Infarction and Worsening Leukoaraiosis in Older Adults. Arterioscler Thromb Vasc Biol. 2017  ;37(8):1579-1586.

de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen M-H, Wang JJin, Attia JR, et al. Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One. 2017  ;12(1):e0167742.

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, et al. The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY). 2017  ;9(1):209-246.

Greenlee H, Strizich G, Lovasi GS, Kaplan RC, Biggs ML, Li CI, Richardson J, Burke GL, Fitzpatrick AL, Fretts AM, et al. Concordance With Prevention Guidelines and Subsequent Cancer, Cardiovascular Disease, and Mortality: A Longitudinal Study of Older Adults. Am J Epidemiol. 2017  ;186(10):1168-1179.

Jensen MK, Jensen RA, Mukamal KJ, Guo X, Yao J, Sun Q, Cornelis M, Liu Y, Chen M-H, Kizer JR, et al. Detection of genetic loci associated with plasma fetuin-A: A meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet. 2017  .

C Y Ng M, Graff M, Lu Y, Justice AE, Mudgal P, Liu C-T, Young K, Yanek LR, Feitosa MF, Wojczynski MK, et al. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium. PLoS Genet. 2017  ;13(4):e1006719.

Hu Y, Tanaka T, Zhu J, Guan W, H Y Wu J, Psaty BM, McKnight B, King IB, Sun Q, Richard M, et al. Discovery and fine-mapping of loci associated with monounsaturated fatty acids through trans-ethnic meta-analysis in Chinese and European populations. J Lipid Res. 2017  .

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min. 2017  ;10:25.

van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, Bihlmeyer NA, Fu Y-P, Weiss S, Lin HJ, et al. Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet. 2017  .

Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai P-C, et al. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. Am J Hum Genet. 2017  ;101(6):888-902.

Nguyen KT, Vittinghoff E, Dewland TA, Dukes JW, Soliman EZ, Stein PK, Gottdiener JS, Alonso A, Chen LY, Psaty BM, et al. Ectopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Community. J Am Heart Assoc. 2017  ;6(8).

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves ACouto, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet. 2017  ;49(12):1758-1766.

Nowak KL, Bartz TM, Dalrymple L, de Boer IH, Kestenbaum B, Shlipak MG, Garimella PS, Ix JH, Chonchol M. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol. 2017  ;28(4):1239-1246.

Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, B??ková P, Carlson CS, Cheng I, Cochran B, et al. Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. Int J Obes (Lond). 2017  ;41(2):324-331.

Weng L-C, Lunetta KL, Müller-Nurasyid M, Smith AVernon, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen L-P, Kleber ME, et al. Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Sci Rep. 2017  ;7(1):11303.

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017  ;49(3):426-432.

Nolte IM, M Munoz L, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, et al. Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017  ;8:15805.

Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, et al. {Genetic Risk Prediction of Atrial Fibrillation. Circulation. 2017  ;135:1311?1320.

Sobrin L, Chong YHe, Fan Q, Gan A, Stanwyck LK, Kaidonis G, Craig JE, Kim J, Liao W-L, Huang Y-C, et al. Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes. 2017  ;66(12):3130-3141.

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, et al. {Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017  ;49:403?415.

Li C, Kim YKyoung, Dorajoo R, Li H, Lee I-T, Cheng C-Y, He M, Sheu WH-H, Guo X, Ganesh SK, et al. Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians. Circ Cardiovasc Genet. 2017  ;10(2):e001527.

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, et al. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet. 2017  ;54(5):313-323.

Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpeläinen TO, Wojczynski MK, Richardson K, Nalls MA, et al. Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Mol Nutr Food Res. 2017  .

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, et al. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 2017  ;8(1):910.

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, et al. {Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017  ;8:14977.

van Rooij FJA, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang L-C, Schmidt H, Yang M-L, et al. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017  ;100(1):51-63.

Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, et al. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017  ;3(6):e1602025.

Alva ML, Hoerger TJ, Zhang P, Gregg EW. Identifying risk for type 2 diabetes in different age cohorts: does one size fit all?. BMJ Open Diabetes Res Care. 2017  ;5(1):e000447.

Wheeler E, Leong A, Liu C-T, Hivert M-F, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017  ;14(9):e1002383.

Zillikens CM, Demissie S, Hsu Y-H, Yerges-Armstrong LM, Chou W-C, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, et al. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017  ;8(1):80.

Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017  ;49(6):946-952.

Lam M, Trampush JW, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, et al. Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep. 2017  ;21(9):2597-2613.

Wild PS, Felix JF, Schillert A, Teumer A, Chen M-H, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, et al. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest. 2017  ;127(5):1798-1812.

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, et al. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nat Commun. 2017  ;8:16015.

Armstrong NM, Carlson MC, Schrack J, Xue Q-L, Carnethon MR, Rosano C, Chaves PHM, Gross AL. Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia. Am J Geriatr Psychiatry. 2017  .

Shadyab AH, Lamonte MJ, Kooperberg C, Reiner AP, Carty CL, Manini TM, Hou L, Di C, Macera CA, Gallo LC, et al. Leisure-time physical activity and leukocyte telomere length among older women. Exp Gerontol. 2017  ;95:141-147.

Manousaki D, Dudding T, Haworth S, Hsu Y-H, Liu C-T, Medina-Gómez C, Voortman T, van der Velde N, Melhus H, Robinson-Cohen C, et al. Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. Am J Hum Genet. 2017  ;101(2):227-238.

Matsushita K, Ballew SH, Coresh J, Arima H, Arnlöv J, Cirillo M, Ebert N, Hiramoto JS, Kimm H, Shlipak MG, et al. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2017  ;5(9):718-728.

Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Cupples AL, W Gauderman J, Rice K, Munroe PB, Psaty BM. Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale. Circ Cardiovasc Genet. 2017  ;10(3).

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, et al. New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475?000 Individuals. Circ Cardiovasc Genet. 2017  ;10(5).

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, A Erzurumluoglu M, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017  .

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, et al. {Novel genetic loci associated with hippocampal volume. Nat Commun. 2017  ;8:13624.

Kent ST, Rosenson RS, Avery CL, Chen Y-derI, Correa A, Cummings SR, Cupples AL, Cushman M, Evans DS, Gudnason V, et al. PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites. Circ Cardiovasc Genet. 2017  ;10(4):e001632.

Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F, Laaksonen MA, Isaacs A, et al. Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J. 2017  .

Kao DP, Stevens LM, Hinterberg MA, Görg C. Phenotype-Specific Association of Single-Nucleotide Polymorphisms with Heart Failure and Preserved Ejection Fraction: a Genome-Wide Association Analysis of the Cardiovascular Health Study. J Cardiovasc Transl Res. 2017  ;10(3):285-294.

Bhambhani V, Kizer JR, Lima JAC, van der Harst P, Bahrami H, Nayor M, de Filippi CR, Enserro D, Blaha MJ, Cushman M, et al. Predictors and outcomes of heart failure with mid-range ejection fraction. Eur J Heart Fail. 2017  .

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017  ;49(9):1373-1384.

Maurer MS, Koh WJH, Bartz TM, Vullaganti S, Barasch E, Gardin JM, Gottdiener JS, Psaty BM, Kizer JR. Relation of the Myocardial Contraction Fraction, as Calculated from M-Mode Echocardiography, With Incident Heart Failure, Atherosclerotic Cardiovascular Disease and Mortality (Results from the Cardiovascular Health Study). Am J Cardiol. 2017  ;119(6):923-928.

Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, et al. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. J Am Coll Cardiol. 2017  ;69(9):1129-1142.

Massera D, Xu S, Bartz TM, Bortnick AE, Ix JH, Chonchol M, Owens DS, Barasch E, Gardin JM, Gottdiener JS, et al. Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people: The Cardiovascular Health Study. Arch Osteoporos. 2017  ;12(1):52.

Paige E, Barrett J, Pennells L, Sweeting M, Willeit P, Di Angelantonio E, Gudnason V, Nordestgaard BG, Psaty BM, Goldbourt U, et al. REPEATED MEASUREMENTS OF BLOOD PRESSURE AND CHOLESTEROL IMPROVES CARDIOVASCULAR DISEASE RISK PREDICTION: AN INDIVIDUAL-PARTICIPANT-DATA META-ANALYSIS. Am J Epidemiol. 2017  .

Armstrong NM, Carlson MC, Xue Q-L, Schrack J, Carnethon MR, Chaves PHM, Gross AL. Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study. J Aging Health. 2017  :898264317744921.

Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, van der Lee SJ, Broer L, Deelen J, Marioni RE, Wong A, et al. Short telomere length is associated with impaired cognitive performance in European ancestry cohorts. Transl Psychiatry. 2017  ;7(4):e1100.

Liang J, Le TH, Edwards DRVelez, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, et al. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet. 2017  ;13(5):e1006728.

Ahiawodzi PD, Kerber RA, Taylor KC, Groves FD, O'Brien E, Ix JH, Kizer JR, Djoussé L, Tracy RP, Newman AB, et al. Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers. 2017  ;22(3-4):361-366.

Kuller LH, Lopez OL, Gottdiener JS, Kitzman DW, Becker JT, Chang Y, Newman AB. Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly. J Am Heart Assoc. 2017  ;6(7).

Steenstrup T, Kark JD, Verhulst S, Thinggaard M, Hjelmborg JVB, Dalgård C, Kyvik KO, Christiansen L, Mangino M, Spector TD, et al. Telomeres and the natural lifespan limit in humans. Aging (Albany NY). 2017  ;9(4):1130-1142.

Baumgartner C, da Costa BR, Collet T-H, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, et al. Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation. Circulation. 2017  ;136(22):2100-2116.

Sanders JL, Guo W, O'Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR. Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2017  .

Fernandez-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y, Highland HM, Yoneyama S, Bush WS, et al. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum Genet. 2017  ;136(6):771-800.

Chibnik LB, Wolters FJ, Bäckman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues J-F, et al. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. Eur J Epidemiol. 2017  ;32(10):931-938.

Ginsberg C, Katz R, de Boer IH, Kestenbaum BR, Chonchol M, Shlipak MG, Sarnak MJ, Hoofnagle AN, Rifkin DE, Garimella PS, et al. The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: The cardiovascular health study. Bone. 2018  ;107:124-130.

Trajanoska K, Morris JA, Oei L, Zheng H-F, Evans DM, Kiel DP, Ohlsson C, J Richards B, Rivadeneira F. Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. BMJ. 2018  ;362:k3225.

Segna D, Bauer DC, Feller M, Schneider C, Fink HA, Aubert CE, Collet T-H, da Costa BR, Fischer K, Peeters RP, et al. Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med. 2018  ;283(1):56-72.

de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, et al. Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction. JAMA Cardiol. 2018  .

Garg PK, Bartz TM, Norby FL, Jorgensen NW, McClelland RL, Ballantyne CM, Chen LY, Gottdiener JS, Greenland P, Hoogeveen R, et al. Association of lipoprotein-associated phospholipase A and risk of incident atrial fibrillation: Findings from 3 cohorts. Am Heart J. 2018  ;197:62-69.

Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, Kizer JR, Sarma A, Blaha MJ, Gansevoort RT, et al. The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF. JACC Heart Fail. 2018  ;6(8):701-709.

Kamel H, Bartz TM, Elkind MSV, Okin PM, Thacker EL, Patton KK, Stein PK, deFilippi CR, Gottesman RF, Heckbert SR, et al. Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study). Stroke. 2018  ;49(4):980-986.

Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L, Grarup N, Müller-Nurasyid M, et al. Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval. Circ Genom Precis Med. 2018  ;11(5):e002037.

Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu C-T, et al. Common Coding Variants in  Are Associated With the Nav1.8 Late Current and Cardiac Conduction. Circ Genom Precis Med. 2018  ;11(5):e001663.

Ashar FN, Mitchell RN, Albert CM, Newton-Cheh C, Brody JA, Müller-Nurasyid M, Moes A, Meitinger T, Mak A, Huikuri H, et al. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J. 2018  .

Huang T, Ding M, Bergholdt HKM, Wang T, Heianza Y, Sun D, Frazier-Wood AC, Aslibekyan S, North KE, Voortman T, et al. {Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies. Clin Chem. 2018  ;64:183?191.

Wu C, G Geldhof J, Xue Q-L, Kim DH, Newman AB, Odden MC. Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results from Two Large U.S. Cohorts. Am J Epidemiol. 2018  .

Kocarnik JM, Richard M, Graff M, Haessler J, Bien S, Carlson C, Carty CL, Reiner AP, Avery CL, Ballantyne CM, et al. Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Mol Genet. 2018  ;27(16):2940-2953.

Ward-Caviness CK, Huffman JE, Evertt K, Germain M, van Dongen J, W Hill D, Jhun MA, Brody JA, Ghanbari M, Du L, et al. DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis. Blood. 2018  .

Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, et al. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. Eur Heart J. 2018  .

Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu F-C, Nho K, Hofer E, Hagenaars SP, et al. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in  for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. Stroke. 2018  .

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, et al. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biol. 2018  ;19(1):87.

Bihlmeyer NA, Brody JA, Smith AVernon, Warren HR, Lin H, Isaacs A, Liu C-T, Marten J, Radmanesh F, Hall LM, et al. ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circ Genom Precis Med. 2018  ;11(1):e001758.

Garg PK, Biggs ML, Kaplan R, Kizer JR, Heckbert SR, Mukamal KJ. Fasting and post-glucose load measures of insulin resistance and risk of incident atrial fibrillation: The Cardiovascular Health Study. Nutr Metab Cardiovasc Dis. 2018  .

Imamura F, Fretts A, Marklund M, Korat AVArdisson, Yang W-S, Lankinen M, Qureshi W, Helmer C, Chen T-A, Wong K, et al. Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLoS Med. 2018  ;15(10):e1002670.

Hodonsky CJo, Schurmann C, Schick UM, Kocarnik J, Tao R, van Rooij FJa, Wassel C, Buyske S, Fornage M, Hindorff LA, et al. Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study. Am J Hematol. 2018  .

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018  ;50(10):1412-1425.

Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, et al. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord. 2018  ;45(1-2):1-17.

Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, van der Most PJ, Tanaka T, Naderi E, Rose LM, et al. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet. 2018  ;103(5):691-706.

Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, et al. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. Nat Commun. 2018  ;9(1):4455.

Napier MD, Franceschini N, Gondalia R, Stewart JD, Méndez-Giráldez R, Sitlani CM, Seyerle AA, Highland HM, Li Y, Wilhelmsen KC, et al. Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy. Sci Rep. 2018  ;8(1):5675.

Jiang X, O'Reilly PF, Aschard H, Hsu Y-H, J Richards B, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, et al. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun. 2018  ;9(1):260.

Vojinovic D, Adams HH, Jian X, Yang Q, Smith AVernon, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018  ;9(1):3945.

Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, et al. Genome-Wide Association Trans-Ethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Circulation. 2018  .

Suri P, Palmer MR, Tsepilov YA, Freidin MB, Boer CG, Yau MS, Evans DS, Gelemanovic A, Bartz TM, Nethander M, et al. Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. PLoS Genet. 2018  ;14(9):e1007601.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018  ;9(1):5141.

Sung YJ, Winkler TW, Fuentes Lde Las, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018  ;102(3):375-400.

Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman JE, Yang Q, Chen M-H, Robinson-Cohen C, Mace A, et al. Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels. Nat Commun. 2018  ;9(1):4228.

Yaghi S, Bartz TM, Kronmal R, Kamel H, Gottdiener J, Longstreth WT, Elkind MSV. Left atrial diameter and vascular brain injury on MRI: The Cardiovascular Health Study. Neurology. 2018  .

Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, et al. {Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet. 2018  ;102:88?102.

Hammond CA, Blades NJ, Chaudhry SI, Dodson JA, Longstreth WT, Heckbert SR, Psaty BM, Arnold AM, Dublin S, Sitlani CM, et al. Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circ Heart Fail. 2018  ;11(3):e004476.

Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, Fried LP, Iacoviello M, Vaes B, Degryse J, et al. Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrol Dial Transplant. 2018  .

Xu J, Bartz TM, Chittoor G, Eiriksdottir G, Manichaikul AW, Sun F, Terzikhan N, Zhou X, Booth SL, Brusselle GG, et al. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. Br J Nutr. 2018  :1-12.

Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M'en, Province MA, Gao W, Qaiser B, et al. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018  ;3:4.

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, R Barr G, Beaty TH, Becker AB, Beilby J, et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018  ;50(1):42-53.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese A-K, van der Laan SW, Gretarsdottir S, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018  ;50(4):524-537.

Roselli C, Chaffin MD, Weng L-C, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018  ;50(9):1225-1233.

Wyss AB, Sofer T, Lee MKyeong, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AVernon, Bartz TM, Feitosa MF, et al. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nat Commun. 2018  ;9(1):2976.

Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, et al. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018  ;58(3):391-401.

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng C-Y, Sim X, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018  ;13(6):e0198166.

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, et al. Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2018  .

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nat Commun. 2018  ;9(1):2904.

Lorenz MW, Gao L, Ziegelbauer K, Norata GDanilo, Empana JPhilippe, Schmidtmann I, Lin H-J, McLachlan S, Bokemark L, Ronkainen K, et al. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLoS One. 2018  ;13(4):e0191172.

Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, et al. Rare loss of function variants in candidate genes and risk of colorectal cancer. Hum Genet. 2018  .

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, N Rayner W, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet. 2018  ;50(4):559-571.

Wopereis DM, Puy RSDu, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, et al. The relation between thyroid function and anemia: a pooled analysis of individual participant data. J Clin Endocrinol Metab. 2018  .

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, et al. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis. 2018  .

Nicholson CJ, Singh K, Saphirstein RJ, Gao YZ, Li Q, Chiu JG, Leavis P, Verwoert GC, Mitchell GF, Porter T, et al. Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces. J Am Heart Assoc. 2018  ;7(15).

Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, Paige E, Paul DS, Sweeting M, Burgess S, et al. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599?912 current drinkers in 83 prospective studies. Lancet. 2018  ;391(10129):1513-1523.

Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen NB, Kuller LH, Greenland P, Eaton CB, Gottdiener JS, et al. Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction. Circulation. 2018  ;137(17):1814-1823.

Davies G, Lam M, Harris SE, Trampush JW, Luciano M, W Hill D, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018  ;9(1):2098.

McKeown NM, Dashti HS, Ma J, Haslam DE, de Jong JCKiefte-, Smith CE, Tanaka T, Graff M, Lemaitre RN, Rybin D, et al. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia. 2018  ;61(2):317-330.

de Haan HG, A Vlieg vanHylckama, Lotta LA, Gorski MM, Bucciarelli P, Martinelli I, Baglin TP, Peyvandi F, Rosendaal FR. Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes. J Thromb Haemost. 2018  .

Tsao CW, Lyass A, Enserro D, Larson MG, Ho JE, Kizer JR, Gottdiener JS, Psaty BM, Vasan RS. Temporal Trends in the Incidence of and Mortality Associated With Heart Failure With Preserved and Reduced Ejection Fraction. JACC Heart Fail. 2018  ;6(8):678-685.

Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, Lim U, Lu Y, Gross M, Fornage M, et al. Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond). 2018  ;42(3):384-390.

Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, et al. Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. J Clin Endocrinol Metab. 2018  .

Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2018  .

Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, et al. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Ann Clin Transl Neurol. 2018  ;5(4):406-417.

Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, et al. Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol. 2018  ;5(7):832-842.

Wang H, Cade BE, Sofer T, Sands SA, Chen H, Browning SR, Stilp AM, Louie TL, Thornton TA, W Johnson C, et al. Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. Hum Mol Genet. 2019  ;28(4):675-687.

Garg PK, Biggs ML, Barzilay J, Djoussé L, Hirsch C, Ix JH, Kizer JR, Tracy RP, Newman AB, Siscovick DS, et al. Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. Diab Vasc Dis Res. 2019  :1479164119847481.

Oelsner EC, Balte PP, Grams ME, Cassano PA, Jacobs DR, R Barr G, Burkart KM, Kalhan R, Kronmal R, Loehr LR, et al. Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study. Am J Respir Crit Care Med. 2019  ;199(3):321-332.

Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, et al. Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study. JAMA Cardiol. 2019  .

Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, H?nninen IK, Tanaka T, de Jonge EAL, et al. {Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. Am J Clin Nutr. 2019  ;110:437?450.

Steubl D, B?zková P, Ix JH, Devarajan P, Bennett MR, Chaves PHM, Shlipak MG, Bansal N, Sarnak MJ, Garimella PS. Association of serum and urinary uromodulin and their correlates in older adults-The Cardiovascular Health Study. Nephrology (Carlton). 2019  .

Steubl D, B?zková P, Garimella PS, Ix JH, Devarajan P, Bennett MR, Chaves PHM, Shlipak MG, Bansal N, Sarnak MJ. Association of serum uromodulin with mortality and cardiovascular disease in the elderly-the Cardiovascular Health Study. Nephrol Dial Transplant. 2019  .

Mishra A, Chauhan G, Violleau M-H, Vojinovic D, Jian X, Bis JC, Li S, Saba Y, Grenier-Boley B, Yang Q, et al. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019  .

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, et al. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 2019  ;10(1):4957.

Fretts AM, Imamura F, Marklund M, Micha R, Wu JHY, Murphy RA, Chien KL, McKnight B, Tintle N, Forouhi NG, et al. {Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. Am. J. Clin. Nutr. 2019  ;109:1216?1223.

Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, et al. Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. PLoS Genet. 2019  ;15(4):e1007739.

Marklund M, H Y Wu J, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, et al. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality. Circulation. 2019  ;139(21):2422-2436.

Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, et al. Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease. Circulation. 2019  ;140(8):645-657.

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. 2019  ;51(6):957-972.

Dörr M, Hamburg NM, Müller C, Smith NL, Gustafsson S, Lehtimäki T, Teumer A, Zeller T, Li X, Lind L, et al. Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation. Circ Genom Precis Med. 2019  ;12(2):e002409.

Karasik D, Zillikens CM, Hsu Y-H, Aghdassi A, Åkesson K, Amin N, Barroso I, Bennett DA, Bertram L, Bochud M, et al. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019  ;109(2):276-287.

Barfield R, Wang H, Liu Y, Brody JA, Swenson B, Li R, Bartz TM, Sotoodehnia N, Chen Y-derI, Cade BE, et al. Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations. Sleep. 2019  .

Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, et al. {Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. Eur Heart J. 2019  ;40:621?631.

Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, et al. {Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019  ;570:71?76.

Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y, Wittemans LBL, Adair LS, et al. {Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Am J Hum Genet. 2019  ;105:15?28.

Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y, Wittemans LBL, Adair LS, et al. {Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Am J Hum Genet. 2019  ;105:670?671.

Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019  ;51(11):1624-1636.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing. Nat Genet. 2019  ;51(3):414-430.

Sáez ME, González-Pérez A, Hernández-Olasagarre B, Beà A, Moreno-Grau S, de Rojas I, Monté-Rubio G, Orellana A, Valero S, Comella JX, et al. Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease. Sci Rep. 2019  ;9(1):16665.

Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, et al. {Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nat Commun. 2019  ;10:4130.

van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, et al. {A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol. 2019  ;2:285.

de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, et al. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. Blood. 2019  ;133(9):967-977.

Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, et al. {Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group. Am J Hypertens. 2019  ;32:1146?1153.

Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Stürmer T, Stewart J, Raffield L, et al. Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group. Am J Hypertens. 2019  ;32(12):1146-1153.

Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, et al. Genome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019  .

Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, et al. {Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Circulation. 2019  ;139:620?635.

L Fuentes deLas, Sung YJ, Sitlani CM, Avery CL, Bartz TM, de Keyser C, Evans DS, Li X, Musani SK, Ruiter R, et al. Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics J. 2019  .

Lindström S, Wang L, Smith EN, Gordon W, Vlieg Avan Hylcka, de Andrade M, Brody JA, Pattee JW, Haessler J, Brumpton BM, et al. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. Blood. 2019  ;134(19):1645-1657.

Timmers PRhj, Mounier N, Läll K, Fischer K, Ning Z, Feng X, Bretherick AD, Clark DW, Agbessi M, Ahsan H, et al. Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. Elife. 2019  ;8.

Wolters FJ, Yang Q, Biggs ML, Jakobsdottir J, Li S, Evans DS, Bis JC, Harris TB, Vasan RS, Zilhao NR, et al. {The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE). PLoS One. 2019  ;14:e0219668.

Sarnowski C, Leong A, Raffield LM, Wu P, de Vries PS, DiCorpo D, Guo X, Xu H, Liu Y, Zheng X, et al. Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program. Am J Hum Genet. 2019  ;105(4):706-718.

Lindström S, Brody JA, Turman C, Germain M, Bartz TM, Smith EN, Chen M-H, Puurunen M, Chasman D, Hassler J, et al. A large-scale exome array analysis of venous thromboembolism. Genet Epidemiol. 2019  .

Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, Fried LP, Iacoviello M, Vaes B, Degryse J, et al. {Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrol Dial Transplant. 2019  ;34:650?659.

Ward-Caviness CK, de Vries PS, Wiggins KL, Huffman JE, Yanek LR, Bielak LF, Giulianini F, Guo X, Kleber ME, Kacprowski T, et al. Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PLoS One. 2019  ;14(5):e0216222.

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al. {A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019  ;10:3669.

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al. {A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019  ;10:3669.

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, et al. {Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019  ;34:1284?1296.

de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, et al. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Am J Epidemiol. 2019  .

Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019  ;51(4):636-648.

Sung YJ, L. Fuentes deLas, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, et al. {A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum. Mol. Genet. 2019  .

Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, de Vries PS, Sung YJu, Schwander K, Cade BE, et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019  ;10(1):5121.

Kilpeläinen TO, Bentley AR, Noordam R, Sung YJu, Schwander K, Winkler TW, Jakupovi? H, Chasman DI, Manning A, Ntalla I, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. 2019  ;10(1):376.

Pollack S, Igo RP, Jensen RA, Christiansen M, Li X, Cheng C-Y, C Y Ng M, Smith AV, Rossin EJ, Segrè AV, et al. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes. 2019  ;68(2):441-456.

Evangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, et al. {New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nat Hum Behav. 2019  ;3:950?961.

Whitman IR, Vittinghoff E, deFilippi CR, Gottdiener JS, Alonso A, Psaty BM, Heckbert SR, Hoogeveen RC, Arking DE, Selvin E, et al. NT -pro BNP as a Mediator of the Racial Difference in Incident Atrial Fibrillation and Heart Failure. J Am Heart Assoc. 2019  ;8(7):e010868.

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, et al. {Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019  ;199:631?642.

Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, et al. Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. PLoS One. 2019  ;14(6):e0218115.

Fleck D, Phu L, Verschueren E, Hinkle T, Reichelt M, Bhangale T, Haley B, Wang Y, Graham R, Kirkpatrick DS, et al. PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease. J Neurosci. 2019  ;39(24):4636-4656.

Merino J, Guasch-Ferr? M, Ellervik C, Dashti HS, Sharp SJ, Wu P, Overvad K, Sarnowski C, Kuokkanen M, Lemaitre RN, et al. {Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis. BMJ. 2019  ;366:l4292.

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, et al. {Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis. 2019  ;73:206?217.

Liang J, Cade BE, He KY, Wang H, Lee J, Sofer T, Williams S, Li R, Chen H, Gottlieb DJ, et al. Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. Am J Hum Genet. 2019  ;105(5):1057-1068.

Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, et al. Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics J. 2019  .

Tin A, Marten J, Kuhns VLHalperin, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, et al. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019  ;51(10):1459-1474.

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, et al. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet. 2019  ;51(1):51-62.

Tehrani DM, Fan W, Nambi V, Gardin J, Hirsch CH, Amsterdam E, deFilippi CR, Polonsky T, Wong ND. Trends in Blood Pressure and High-Sensitivity Cardiac Troponin-T with Cardiovascular Disease: The Cardiovascular Health Study. Am J Hypertens. 2019  .

Hazzouri AZeki Al, Vittinghoff E, Zhang Y, Pletcher MJ, Moran AE, Bibbins-Domingo K, Golden SH, Yaffe K. Use of a pooled cohort to impute cardiovascular disease risk factors across the adult life course. Int J Epidemiol. 2019  ;48(3):1004-1013.

Sofer T, Emery L, Jain D, Ellis AM, Laurie CC, Allison MA, Lee J, Kurniansyah N, Kerr KF, Gonz?lez HM, et al. {Variants Associated with the Ankle Brachial Index Differ by Hispanic/Latino Ethnic Group: a genome-wide association study in the Hispanic Community Health Study/Study of Latinos. Sci Rep. 2019  ;9:11410.

Levine DA, Gross AL, Briceño EM, Tilton N, Kabeto MU, Hingtgen SM, Giordani BJ, Sussman JB, Hayward RA, Burke JF, et al. Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals. JAMA Neurol. 2020  .

Garg PK, Tan AX, Odden MC, Gardin JM, Lopez OL, Newman AB, Rawlings AM, Mukamal KJ. Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study. Alzheimer Dis Assoc Disord. 2020  ;34(3):272-274.

Suzuki T, Wang W, Wilsdon A, Butler KR, Adabag S, Griswold ME, Nambi V, Rosamond W, Sotoodehnia N, Mosley TH. Carotid Intima-Media Thickness and the Risk of Sudden Cardiac Death: The ARIC Study and the CHS. J Am Heart Assoc. 2020  ;9(19):e016981.

Duan W, Sehrawat P, Balachandrasekaran A, Bhumkar AB, Boraste PB, Becker JT, Kuller LH, Lopez OL, H Gach M, Dai W. Cerebral Blood Flow Is Associated with Diagnostic Class and Cognitive Decline in Alzheimer's Disease. J Alzheimers Dis. 2020  ;76(3):1103-1120.

Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, et al. {Cerebral small vessel disease genomics and its implications across the lifespan. Nat Commun. 2020  ;11:6285.

Patel RB, Delaney JA, Hu M, Patel H, Cheng J, Gottdiener J, Kizer JR, Marcus GM, Turakhia MP, Deo R, et al. Characterization of cardiac mechanics and incident atrial fibrillation in participants of the Cardiovascular Health Study. JCI Insight. 2020  ;5(19).

Moll M, Sakornsakolpat P, Shrine N, Hobbs BD, DeMeo DL, John C, Guyatt AL, McGeachie MJ, Gharib SA, Obeidat M'en, et al. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020  ;8(7):696-708.

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, et al. {Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020  ;52:1314?1332.

Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, et al. {Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020  ;52:969?983.

Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, H Gach M, Kuller LH, Longstreth W, Carmichael OT, Riedel BC, et al. Estrogen, brain structure, and cognition in postmenopausal women. Hum Brain Mapp. 2020  .

Imamura F, Fretts AM, Marklund M, Korat AVArdisso, Yang WS, Lankinen M, Qureshi W, Helmer C, Chen TA, Virtanen JK, et al. {Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLoS Med. 2020  ;17:e1003102.

Fuentes Lde Las, Sung YJu, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry. 2020  .

Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAgnes B, et al. The genetic architecture of the human cerebral cortex. Science [Internet]. 2020  ;367(6484):eaay6690. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.aay6690https://syndication.highwire.org/content/doi/10.1126/science.aay6690https://syndication.highwire.org/content/doi/10.1126/science.aay6690

Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, et al. {Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020  ;11:4796.

Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H, Teumer A, Li-Gao R, et al. {Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation. Circ Genom Precis Med. 2020  .

Hahn J, Fu Y-P, Brown MR, Bis JC, de Vries PS, Feitosa MF, Yanek LR, Weiss S, Giulianini F, Smith AVernon, et al. Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. PLoS One. 2020  ;15(11):e0230035.

Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LOpal, Bradfield J, Schurmann C, Fine RS, Preuss MH, Kutalik Z, et al. Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity. Diabetes. 2020  .

Shah S, Henry A, Roselli C, Lin H, Sveinbj?rnsson G, Fatemifar G, Hedman ?K, Wilk JB, Morley MP, Chaffin MD, et al. {Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat Commun. 2020  ;11:163.

Keene KL, Hyacinth HI, Bis JC, Kittner SJ, Mitchell BD, Cheng YC, Pare G, Chong M, O'Donnell M, Meschia JF, et al. {Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. Stroke. 2020  ;51:2454?2463.

Barzilay JI, B?zková P, Shlipak MG, Bansal N, Garimella P, Mukamal KJ. Hospitalization Rates in Older Adults with Albuminuria: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2020  .

Wildisen L, Del Giovane C, Moutzouri E, Beglinger S, Syrogiannouli L, Collet TH, Cappola AR, svold BO ?, Bakker SJL, Yeap BB, et al. {An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Sci Rep. 2020  ;10:19111.

Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020  ;586(7831):763-768.

Häberle AD, Biggs ML, Cushman M, Psaty BM, Newman AB, Shlipak MG, Gottdiener J, Wu C, Gardin JM, Bansal N, et al. Level and change in N-terminal pro B-type Natriuretic Peptide and kidney function and survival to age 90. J Gerontol A Biol Sci Med Sci. 2020  .

Zheng Y, Huang T, Wang T, Mei Z, Sun Z, Zhang T, Ellervik C, Chai J-F, Sim X, van Dam RM, et al. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. Eur J Epidemiol. 2020  ;35(7):685-697.

Gorski M, Jung B, Li Y, Matias-Garcia PR, Wuttke M, Coassin S, Thio CHL, Kleber ME, Winkler TW, Wanner V, et al. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. Kidney Int. 2020  .

Zhao D, Bartz TM, Sotoodehnia N, Post WS, Heckbert SR, Alonso A, Longchamps RJ, Castellani CA, Hong YS, Rotter JI, et al. {Mitochondrial DNA copy number and incident atrial fibrillation. BMC Med. 2020  ;18:246.

Castellani CA, Longchamps RJ, Sumpter JA, Newcomb CE, Lane JA, Grove ML, Bressler J, Brody JA, Floyd JS, Bartz TM, et al. Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome Med. 2020  ;12(1):84.

Ntalla I, Weng L-C, Cartwright JH, Hall AWeber, Sveinbjornsson G, Tucker NR, Choi SHoan, Chaffin MD, Roselli C, Barnes MR, et al. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nat Commun. 2020  ;11(1):2542.

Juraschek SP, Longstreth WT, Lopez OL, Gottdiener JS, Lipsitz LA, Kuller LH, Mukamal KJ. Orthostatic Hypotension, Dizziness, Neurology Outcomes, and Death in Older Adults. Neurology. 2020  .

Khera R, Pandey A, Ayers CR, Carnethon MR, Greenland P, Ndumele CE, Nambi V, Seliger SL, Chaves PHM, Safford MM, et al. Performance of the Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Body Mass Index. JAMA Netw Open. 2020  ;3(10):e2023242.

Vuckovic D, Bao EL, Akbari P, Lareau CA, Mousas A, Jiang T, Chen M-H, Raffield LM, Tardaguila M, Huffman JE, et al. The Polygenic and Monogenic Basis of Blood Traits and Diseases. Cell. 2020  ;182(5):1214-1231.e11.

Mathenge N, Fan W, Wong ND, Hirsch C, Delaney CJoseph, Amsterdam EA, Koch B, Calara R, Gardin JM. Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study. Diab Vasc Dis Res. 2020  ;17(1):1479164119888476.

Gottdiener JS, Seliger S, DeFilippi C, Christenson R, Baldridge AS, Kizer JR, Psaty BM, Shah SJ. Relation of Biomarkers of Cardiac Injury, Stress, and Fibrosis With Cardiac Mechanics in Patients ? 65 Years of Age. Am J Cardiol. 2020  .

Wang Z, Chen H, Bartz TM, Bielak LF, Chasman DI, Feitosa MF, Franceschini N, Guo X, Lim E, Noordam R, et al. Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels. Circ Genom Precis Med. 2020  ;13(4):e002772.

Suthahar N, Lau ES, Blaha MJ, Paniagua SM, Larson MG, Psaty BM, Benjamin EJ, Allison MA, Bartz TM, Januzzi JL, et al. Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure. J Am Coll Cardiol. 2020  ;76(12):1455-1465.

Al-Kindi SG, B?zková P, Shitole SG, Reiner AP, Garg PK, Gottdiener JS, Psaty BM, Kizer JR. Soluble CD14 and Risk of Heart Failure and Its Subtypes in Older Adults. J Card Fail. 2020  ;26(5):410-419.

Chen M-H, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, Trivedi B, Jiang T, Akbari P, Vuckovic D, et al. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020  ;182(5):1198-1213.e14.

Ma J, Rebholz CM, Braun KVE, Reynolds LM, Aslibekyan S, Xia R, Biligowda NG, Huan T, Liu C, Mendelson MM, et al. Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality. Circ Genom Precis Med. 2020  ;13(4):e002766.

Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAGagliano, et al. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020  ;11(1):5182.

Massera D, Hu M, Delaney JA, Bartz TM, Bach ME, Dvorak SJ, deFilippi CR, Psaty BM, Gottdiener JS, Kizer JR, et al. Adverse cardiac mechanics and incident coronary heart disease in the Cardiovascular Health Study. Heart. 2021  .

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, A. Vlieg vanHylckama, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, et al. {Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. Blood. 2021  ;137:2394?2402.

Murthy SB, Zhang C, Diaz I, Levitan EB, Koton S, Bartz TM, DeRosa JT, Strobino K, Colantonio LD, Iadecola C, et al. Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies. JAMA Neurol. 2021  ;78(7):809-816.

Tan AX, Shah SJ, Sanders JL, Psaty BM, Wu C, Gardin JM, Peralta CA, Newman AB, Odden MC. Association Between Myocardial Strain and Frailty in CHS. Circ Cardiovasc Imaging. 2021  ;14(5):e012116.

Wan ES, Balte P, Schwartz JE, Bhatt SP, Cassano PA, Couper D, Daviglus ML, Dransfield MT, Gharib SA, Jacobs DR, et al. Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults. JAMA. 2021  ;326(22):2287-2298.

Bressler J, Davies G, Smith AV, Saba Y, Bis JC, Jian X, Hayward C, Yanek L, Smith JA, Mirza SS, et al. Association of low-frequency and rare coding variants with information processing speed. Transl Psychiatry. 2021  ;11(1):613.

Liu X, Longchamps RJ, Wiggins KL, Raffield LM, Bielak LF, Zhao W, Pitsillides A, Blackwell TW, Yao J, Guo X, et al. Association of mitochondrial DNA copy number with cardiometabolic diseases. Cell Genom. 2021  ;1(1).

Besser LM, Lovasi GS, Michael YL, Garg P, Hirsch JA, Siscovick D, Hurvitz P, Biggs ML, Galvin JE, Bartz TM, et al. Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study. Soc Psychiatry Psychiatr Epidemiol. 2021  .

Sofer T, Lee J, Kurniansyah N, Jain D, Laurie CA, Gogarten SM, Conomos MP, Heavner B, Hu Y, Kooperberg C, et al. BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion. HGG Adv. 2021  ;2(3).

Harris WS, Tintle NL, Imamura F, Qian F, Korat AVArdisson, Marklund M, Djoussé L, Bassett JK, Carmichael P-H, Chen Y-Y, et al. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Nat Commun. 2021  ;12(1):2329.

Hazzouri AZeki Al, Vittinghoff E, Hoang T, Golden SH, Fitzpatrick AL, Zhang A, Grasset L, Yaffe K. Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort. Alzheimers Dement. 2021  .

Yaffe K, Vittinghoff E, Hoang T, Matthews K, Golden SH, Hazzouri AZeki Al. Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study. Neurology. 2021  ;96(17):e2212-e2219.

Duan W, Zhou GD, Balachandrasekaran A, Bhumkar AB, Boraste PB, Becker JT, Kuller LH, Lopez OL, H Gach M, Dai W. Cerebral Blood Flow Predicts Conversion of Mild Cognitive Impairment into Alzheimer's Disease and Cognitive Decline: An Arterial Spin Labeling Follow-up Study. J Alzheimers Dis. 2021  ;82(1):293-305.

Natarajan P, Pampana A, Graham SE, Ruotsalainen SE, Perry JA, de Vries PS, Broome JG, Pirruccello JP, Honigberg MC, Aragam K, et al. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021  ;12(1):2182.

Owens DS, Bartz TM, B?zková P, Massera D, Biggs ML, Carlson SD, Psaty BM, Sotoodehnia N, Gottdiener JS, Kizer JR. Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults. Heart. 2021  .

Brenowitz WD, Hazzouri AZeki Al, Vittinghoff E, Golden SH, Fitzpatrick AL, Yaffe K. Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline. J Alzheimers Dis. 2021  ;83(3):1379-1389.

Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, et al. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021  ;12(1):3505.

Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V, Rand K, Feitosa MF, et al. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. Am J Hum Genet. 2021  ;108(4):564-582.

Djoussé L, Zhou G, McClelland RL, Ma N, Zhou X, Kabagambe EK, Talegawkar SA, Judd SE, Biggs ML, Fitzpatrick AL, et al. Egg consumption, overall diet quality, and risk of type 2 diabetes and coronary heart disease: A pooling project of US prospective cohorts. Clin Nutr. 2021  ;40(5):2475-2482.

Roberts JD, Vittinghoff E, Lu AT, Alonso A, Wang B, Sitlani CM, Mohammadi-Shemirani P, Fornage M, Kornej J, Brody JA, et al. Epigenetic Age and the Risk of Incident Atrial Fibrillation. Circulation. 2021  ;144(24):1899-1911.

Karabegovi? I, Portilla-Fernandez E, Li Y, Ma J, Maas SCE, Sun D, Hu EA, Kühnel B, Zhang Y, Ambatipudi S, et al. {Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nat Commun. 2021  ;12:2830.

Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, et al. Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nat Commun. 2021  ;12(1):7173.

Thibord F, Song C, Pattee J, Rodriguez BAT, Chen M-H, O'Donnell CJ, Kleber ME, Delgado GE, Guo X, Yao J, et al. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. J Thromb Haemost. 2021  .

Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, et al. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021  ;596(7872):393-397.

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, et al. {Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Hum Mol Genet. 2021  .

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, et al. {Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021  ;12:654.

Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Malarstig A, Andersson C, Verweij N, Holmes MV, et al. {The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail. 2021  .

Yang Y, Bartz TM, Brown MR, Guo X, Zilhão NR, Trompet S, Weiss S, Yao J, Brody JA, deFilippi CR, et al. Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021  ;14(6):e003460.

Sarnowski C, Chen H, Biggs ML, Wassertheil-Smoller S, Bressler J, Irvin MR, Ryan KA, Karasik D, Arnett DK, Cupples AL, et al. Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program. PLoS One. 2021  ;16(7):e0253611.

He Z, Liu L, Wang C, Le Guen Y, Lee J, Gogarten S, Lu F, Montgomery S, Tang H, Silverman EK, et al. Identification of putative causal loci in whole-genome sequencing data via knockoff statistics. Nat Commun. 2021  ;12(1):3152.

Shah M, Rodriguez CJ, Bartz TM, Lyles MF, Kizer JR, Aurigemma GP, Gardin JM, Gottdiener JS. Incidence, Determinants and Mortality of Heart Failure Associated With Medical-Surgical Procedures in Patients ? 65 Years of Age (from the Cardiovascular Health Study). Am J Cardiol. 2021  ;153:71-78.

Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Weihs A, Yu Z, Hoppmann A, Grundner-Culemann F, et al. Meta-analyses identify DNA methylation associated with kidney function and damage. Nat Commun. 2021  ;12(1):7174.

Portilla-Fernández E, Hwang S-J, Wilson R, Maddock J, W Hill D, Teumer A, Mishra PP, Brody JA, Joehanes R, Ligthart S, et al. Meta-analysis of epigenome-wide association studies of carotid intima-media thickness. Eur J Epidemiol. 2021  .

Sun D, Richard M, Musani SK, Sung YJu, Winkler TW, Schwander K, Chai JFang, Guo X, Kilpeläinen TO, Vojinovic D, et al. Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits. HGG Adv. 2021  ;2(1).

Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJu, Bentley AR, Manning AK, Aschard H, et al. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021  .

Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman ÅK, et al. {A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. Nat Commun. 2021  ;12:3987.

Lu Y, Dimitrov L, Chen S-H, Bielak LF, Bis JC, Feitosa MF, Lu L, Kavousi M, Raffield LM, Smith AV, et al. Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes. Circ Genom Precis Med. 2021  ;14(4):e003258.

Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Gallì A, Castellano CA, McConkey M, Tarun A, et al. is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discov. 2021  ;2(5):500-517.

Qian F, Korat AVArdisso, Imamura F, Marklund M, Tintle N, Virtanen JK, Zhou X, Bassett JK, Lai H, Hirakawa Y, et al. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies. Diabetes Care. 2021  ;44:1133?1142.

Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, et al. {The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021  ;600:675?679.

Limpitikul WB, Dewland TA, Vittinghoff E, Soliman E, Nah G, Fang C, Siscovick DS, Psaty BM, Sotoodehnia N, Heckbert S, et al. Premature ventricular complexes and development of heart failure in a community-based population. Heart. 2021  .

Briceño EM, Gross AL, Giordani BJ, Manly JJ, Gottesman RF, Elkind MSV, Sidney S, Hingtgen S, Sacco RL, Wright CB, et al. Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS. J Alzheimers Dis. 2021  ;83(4):1803-1813.

Yang T, Jackson VE, Smith AV, Chen H, Bartz TM, Sitlani CM, Psaty BM, Gharib SA, O'Connor GT, Dupuis J, et al. {Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function. Sci Rep. 2021  ;11:19365.

Choi SH, Jurgens SJ, Haggerty CM, Hall AW, Halford JL, Morrill VN, Weng LC, Lagerman B, Mirshahi T, Pettinger M, et al. {Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis. Circ Genom Precis Med. 2021  ;14:e003300.

Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAGagliano, Corvelo A, Gogarten SM, Kang HMin, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021  ;590(7845):290-299.

Levine DA, Gross AL, Briceño EM, Tilton N, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Hingtgen S, Elkind MSV, et al. Sex Differences in Cognitive Decline Among US Adults. JAMA Netw Open. 2021  ;4(2):e210169.

Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, et al. {Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021  ;12:24.

Lagou V, M?gi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, et al. {Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021  ;12:24.

Hazzouri AZeki Al, Jawadekar N, Grasset L, Kaiser P, Kezios K, Calonico S, M Glymour M, Hirsch C, Arnold AM, Varadhan R, et al. Statins and cognitive decline in the Cardiovascular Health Study: A comparison of different analytical approaches. J Gerontol A Biol Sci Med Sci. 2021  .

Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkänen N, et al. Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. Circ Genom Precis Med. 2021  ;14(4):e003288.

Yu B, Roberts MB, Raffield LM, Zekavat SMaryam, Nguyen NQuynh H, Biggs ML, Brown MR, Griffin G, Desai P, Correa A, et al. Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure. J Am Coll Cardiol. 2021  ;78(1):42-52.

Stilp AM, Emery LS, Broome JG, Buth EJ, Khan AT, Laurie CA, Wang FFei, Wong Q, Chen D, D'Augustine CM, et al. A System for Phenotype Harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. Am J Epidemiol. 2021  .

Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, et al. {The trans-ancestral genomic architecture of glycemic traits. Nat Genet. 2021  ;53:840?860.

Barzilay JI, B?zková P, Shlipak MG, Lyles MF, Bansal N, Garimella PS, Ix JH, Kizer JR, Strotmeyer ES, Djoussé L, et al. Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study. J Am Geriatr Soc. 2021  .

Lin BM, Grinde KE, Brody JA, Breeze CE, Raffield LM, Mychaleckyj JC, Thornton TA, Perry JA, Baier LJ, Fuentes Lde Las, et al. Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium. EBioMedicine. 2021  ;63:103157.

Little A, Hu Y, Sun Q, Jain D, Broome J, Chen M-H, Thibord F, McHugh C, Surendran P, Blackwell TW, et al. Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative. Hum Mol Genet. 2021  .

Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, et al. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021  ;13(1):136.

Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, de Bellefon SMéric, Raffield LM, Chen M-H, et al. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet. 2021  ;108(5):874-893.

Mikhaylova AV, McHugh CP, Polfus LM, Raffield LM, Boorgula MPreethi, Blackwell TW, Brody JA, Broome J, Chami N, Chen M-H, et al. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet. 2021  ;108(10):1836-1851.

Wainschtein P, Jain D, Zheng Z, Cupples AL, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, et al. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet. 2022  ;54(3):263-273.

Barasch E, Gottdiener JS, Tressel W, Bartz TM, B?zková P, Massera D, DeFilippi C, Biggs ML, Psaty BM, Kizer JR, et al. The association of aortic valve sclerosis, aortic annulus increased reflectivity, and mitral annular calcification with subsequent aortic stenosis in older individuals. Findings from the Cardiovascular Health Study. J Am Soc Echocardiogr. 2022  .

Frenzel S, Bis JC, Gudmundsson EF, O'Donnell A, Simino J, Yaqub A, Bartz TM, Brusselle GGO, Bülow R, DeCarli CS, et al. Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis. J Alzheimers Dis. 2022  .

Zhang L, Bartz TM, Santanasto A, Djoussé L, Mukamal KJ, Forman DE, Hirsch CH, Newman AB, Gottdiener JS, Kizer JR. Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts. J Am Heart Assoc. 2022  ;11(1):e023707.

Njoroge JN, Tressel W, Biggs ML, Matsumoto AM, Smith NL, Rosenberg E, Hirsch CH, Gottdiener JS, Mukamal KJ, Kizer JR. Circulating Androgen Concentrations and Risk of Incident Heart Failure in Older Men: The Cardiovascular Health Study. J Am Heart Assoc. 2022  ;11(21):e026953.

Durda P, Raffield LM, Lange EM, Olson NC, Jenny NSwords, Cushman M, Deichgraeber P, Grarup N, Jonsson A, Hansen T, et al. Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study. J Am Heart Assoc. 2022  ;11(21):e024374.

Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MMesbah, Bick AG, Niroula A, Yu B, Gibson C, et al. Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Stroke. 2022  ;53(3):788-797.

Uddin MDM, Nguyen NQH, Yu B, Brody JA, Pampana A, Nakao T, Fornage M, Bressler J, Sotoodehnia N, Weinstock JS, et al. {Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Nat Commun. 2022  ;13:5350.

Elgart M, Goodman MO, Isasi C, Chen H, Morrison AC, de Vries PS, Xu H, Manichaikul AW, Guo X, Franceschini N, et al. Correlations between complex human phenotypes vary by genetic background, gender, and environment. Cell Rep Med. 2022  ;3(12):100844.

Thibord F, Klarin D, Brody JA, Chen M-H, Levin MG, Chasman DI, Goode EL, Hveem K, Teder-Laving M, Martinez-Perez A, et al. Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors. Circulation. 2022  ;146(16):1225-1242.

Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, Stanzick KJ, Thomas LF, Tin A, Hoppmann A, Chu AY, et al. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Commun Biol. 2022  ;5(1):580.

Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B, Walton E, Mishra PP, et al. {DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. 2022  ;13:2408.

Halford JL, Morrill VN, Choi SHoan, Jurgens SJ, Melloni G, Marston NA, Weng L-C, Nauffal V, Hall AW, Gunn S, et al. Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nat Commun. 2022  ;13(1):5106.

Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, et al. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. Brain. 2022  .

Li Z, Li X, Zhou H, Gaynor SM, Selvaraj MSunitha, Arapoglou T, Quick C, Liu Y, Chen H, Sun R, et al. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nat Methods. 2022  ;19(12):1599-1611.

Mishra A, Duplaà C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhao NR, Li S, Bartz TM, Jian X, Zhao W, et al. {Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2022  ;145:1992?2007.

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins JW, et al. {Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nat Commun. 2022  ;13:5144.

Portilla-Fernandez E, Klarin D, Hwang SJ, Biggs ML, Bis JC, Weiss S, Rospleszcz S, Natarajan P, Hoffmann U, Rogers IS, et al. {Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study. Hum Mol Genet. 2022  ;31:3566?3579.

Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai J-F, et al. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Kidney Int. 2022  .

Downie CG, Highland HM, Lee MP, Raffield LM, Preuss M, Whitsel EA, Psaty BM, Sitlani CM, Graff M, Avery CL. Genome Wide Association Studies of Variant-by-Thiazide Interaction on Lipids Identifies a Novel Low-Density Lipoprotein Cholesterol Locus. Circ Res. 2022  ;131(3):277-279.

Thériault S, Imboden M, Biggs ML, Austin TR, Aeschbacher S, Schaffner E, Brody JA, Bartz TM, Risch M, Grossmann K, et al. Genome-wide analyses identify  as a susceptibility locus for premature atrial contraction frequency. iScience. 2022  ;25(10):105210.

Longchamps RJ, Yang SY, Castellani CA, Shi W, Lane J, Grove ML, Bartz TM, Sarnowski C, Liu C, Burrows K, et al. {Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation. Hum Genet. 2022  ;141:127?146.

Lahti J, Tuominen S, Yang Q, Pergola G, Ahmad S, Amin N, Armstrong NJ, Beiser A, Bey K, Bis JC, et al. Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Mol Psychiatry. 2022  .

Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N, Biggs ML, Kleber ME, et al. {Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases. JCI Insight. 2022  ;7.

Garg PK, Biggs ML, Kizer JR, Shah SJ, Psaty B, Carnethon M, Gottdiener JS, Siscovick D, Mukamal KJ. Glucose dysregulation and subclinical cardiac dysfunction in older adults: The Cardiovascular Health Study. Cardiovasc Diabetol. 2022  ;21(1):112.

Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, et al. {Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol. 2022  ;23:268.

Kelly TN, Sun X, He KY, Brown MR, Taliun SAGagliano, Hellwege JN, Irvin MR, Mi X, Brody JA, Franceschini N, et al. Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. Hypertension. 2022  :101161HYPERTENSIONAHA12219324.

Huan T, Nguyen S, Colicino E, Ochoa-Rosales C, W Hill D, Brody JA, Soerensen M, Zhang Y, Baldassari A, Elhadad MAhmed, et al. Integrative analysis of clinical and epigenetic biomarkers of mortality. Aging Cell. 2022  ;21(6):e13608.

Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KMin, Fang H, Chen F, Lu Y, et al. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med. 2022  ;28(8):1679-1692.

Nauffal V, Morrill VN, Jurgens SJ, Choi SHoan, Hall AW, Weng L-C, Halford JL, Austin-Tse C, Haggerty CM, Harris SL, et al. Monogenic and Polygenic Contributions to QTc Prolongation in the Population. Circulation. 2022  .

Mahajan A, Spracklen CN, Zhang W, C Y Ng M, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJin, et al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022  ;54(5):560-572.

Kurniansyah N, Goodman MO, Kelly TN, Elfassy T, Wiggins KL, Bis JC, Guo X, Palmas W, Taylor KD, Lin HJ, et al. A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood. Nat Commun. 2022  ;13(1):3549.

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 2022  ;54(4):412-436.

Elgart M, Lyons G, Romero-Brufau S, Kurniansyah N, Brody JA, Guo X, Lin HJ, Raffield L, Gao Y, Chen H, et al. Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations. Commun Biol. 2022  ;5(1):856.

Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, et al. {Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2022  ;45:232?240.

Duan W, Sehrawat P, Zhou TD, Becker JT, Lopez OL, H Gach M, Dai W. Pattern of Altered Magnetization Transfer Rate in Alzheimer's Disease. J Alzheimers Dis. 2022  .

Lemaitre RN, Jensen PN, Zeigler M, Fretts AM, Umans JG, Howard BV, Sitlani CM, McKnight B, Gharib SA, King IB, et al. Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study. EBioMedicine. 2022  ;83:104189.

Liu X, Pan S, Xanthakis V, Vasan RS, Psaty BM, Austin TR, Newman AB, Sanders JL, Wu C, Tracy RP, et al. Plasma proteomic signature of decline in gait speed and grip strength. Aging Cell. 2022  ;21(12):e13736.

Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B, et al. Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. Am J Hum Genet. 2022  .

Gonzales MM, Wiedner C, Wang CP, Liu Q, Bis JC, Li Z, Himali JJ, Ghosh S, Thomas EA, Parent DM, et al. {A population-based meta-analysis of circulating GFAP for cognition and dementia risk. Ann Clin Transl Neurol. 2022  ;9:1574?1585.

Carew AS, Mekary RA, Kirkland S, Theou O, Siddiqi F, Urquhart R, George M, Blanchard C, Biggs ML, Djoussé L, et al. Prospective study of breakfast frequency and timing and the risk of incident type 2 diabetes in community-dwelling older adults: The Cardiovascular Health Study. Am J Clin Nutr. 2022  .

Austin TR, McHugh CP, Brody JA, Bis JC, Sitlani CM, Bartz TM, Biggs ML, Bansal N, B?zková P, Carr SA, et al. Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing. Eur J Epidemiol. 2022  .

Murphy RA, Tintle N, Harris WS, Darvishian M, Marklund M, Virtanen JK, Hantunen S, de Mello VD, Tuomilehto J, Lindström J, et al. PUFA ?-3 and ?-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE). Am J Clin Nutr. 2022  ;115(3):864-876.

Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MSunitha, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, et al. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022  ;109(1):81-96.

Jang S-K, Evans L, Fialkowski A, Arnett DK, Ashley-Koch AE, Barnes KC, Becker DM, Bis JC, Blangero J, Bleecker ER, et al. Rare genetic variants explain missing heritability in smoking. Nat Hum Behav. 2022  .

Gottdiener JS, B?zková P, Kahn PA, DeFilippi C, Shah S, Barasch E, Kizer JR, Psaty B, Gardin JM. Relation of Cigarette Smoking and Heart Failure in Adults ?65 Years of Age (From the Cardiovascular Health Study). Am J Cardiol. 2022  .

Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, et al. {A saturated map of common genetic variants associated with human height. Nature. 2022  ;610:704?712.

Gao H, Patel S, Fohtung RB, Cawthon PM, Newman AB, Cauley JA, Carbone L, Chaves PHM, Stein PK, Civitelli R, et al. Sex- and race-specific associations of bone mineral density with incident heart failure and its subtypes in older adults. J Am Geriatr Soc. 2022  .

Sillah A, Watson NF, Peters U, Biggs ML, F Nieto J, Li CI, Gozal D, Thornton T, Barrie S, Phipps AI. Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS). Cancer Epidemiol. 2022  ;76:102057.

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022  .

Liang J, Wang H, Cade BE, Kurniansyah N, He KY, Lee J, Sands SA, Brody J, Chen H, Gottlieb DJ, et al. Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2022  .

Lai HTM, Imamura F, Korat AVA, Murphy RA, Tintle N, Bassett JK, Chen J, ger J, Chien KL, Senn M, et al. {Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE). Diabetes Care. 2022  ;45:854?863.

Wang Z, Choi SWan, Chami N, Boerwinkle E, Fornage M, Redline S, Bis JC, Brody JA, Psaty BM, Kim W, et al. The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations. Front Endocrinol (Lausanne). 2022  ;13:863893.

Pankratz N, Wei P, Brody JA, Chen M-H, Vries PS, Huffman JE, Stimson MRachel, Auer PL, Boerwinkle E, Cushman M, et al. Whole exome sequencing of 14?389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors. Hum Mol Genet. 2022  .

DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, et al. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program. Commun Biol. 2022  ;5(1):756.

Wheeler MM, Stilp AM, Rao S, Halldorsson BV, Beyter D, Wen J, Mihkaylova AV, McHugh CP, Lane J, Jiang M-Z, et al. Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program. Nat Commun. 2022  ;13(1):7592.

Pan Y, Sun X, Mi X, Huang Z, Hsu Y, Hixson JE, Munzy D, Metcalf G, Franceschini N, Tin A, et al. Whole-Exome Sequencing Study Identifies Four Novel Gene Loci Associated with Diabetic Kidney Disease. Hum Mol Genet. 2022  .

Weinstock JS, Gopakumar J, Burugula BBharathi, Uddin MMesbah, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, et al. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature. 2023  ;616(7958):755-763.

Ji Y, Temprano-Sagrera G, Holle LA, Bebo A, Brody JA, Le N-Q, Kangro K, Brown MR, Martinez-Perez A, Sitlani CM, et al. Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels. Arterioscler Thromb Vasc Biol. 2023  ;43(7):e254-e269.

Yi J, Wang L, Guo X, Ren X. Association between 5-year change in cardiovascular risk and the incidence of atherosclerotic cardiovascular diseases: a multi-cohort study. J Transl Med. 2023  ;21(1):589.

Johansen MC, Ye W, Gross A, Gottesman RF, Han D, Whitney R, Briceño EM, Giordani BJ, Shore S, Elkind MSV, et al. Association Between Acute Myocardial Infarction and Cognition. JAMA Neurol. 2023  .

Liu X, Sun X, Zhang Y, Jiang W, Lai M, Wiggins KL, Raffield LM, Bielak LF, Zhao W, Pitsillides A, et al. Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk. J Am Heart Assoc. 2023  :e029090.

Zhang Y, Liu X, Wiggins KL, Kurniansyah N, Guo X, Rodrigue AL, Zhao W, Yanek LR, Ratliff SM, Pitsillides A, et al. Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts. Neurology. 2023  .

Quaye E, Galecki AT, Tilton N, Whitney R, Briceño EM, Elkind MSV, Fitzpatrick AL, Gottesman RF, Griswold M, Gross AL, et al. Association of Obesity With Cognitive Decline in Black and White Americans. Neurology. 2023  ;100(2):e220-e231.

Ong KLeung, Marklund M, Huang L, Rye K-A, Hui N, Pan X-F, Rebholz CM, Kim H, Steffen LM, van Westing AC, et al. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ. 2023  ;380:e072909.

Dron JS, Patel AP, Zhang Y, Jurgens SJ, Maamari DJ, Wang M, Boerwinkle E, Morrison AC, de Vries PS, Fornage M, et al. Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease. JAMA Cardiol. 2023  .

Zhang Y, Dron JS, Bellows BK, Khera AV, Liu J, Balte PP, Oelsner EC, Amr SSamir, Lebo MS, Nagy A, et al. Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease. Circulation. 2023  ;147(20):1556-1559.

Levine DA, Chen B, Galecki AT, Gross AL, o EM, Whitney RT, Ploutz-Snyder RJ, Giordani BJ, Sussman JB, Burke JF, et al. {Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors. JAMA Netw Open. 2023  ;6:e2313879.

Mehta R, B?zková P, Patel H, Cheng J, Kizer JR, Gottdiener JS, Psaty B, Khan SS, Ix JH, Isakova T, et al. Cardiac Mechanics and Kidney Function Decline in the Cardiovascular Health Study. Kidney360. 2023  .

Georgakis MK, Malik R, Hasbani NR, Shakt G, Morrison AC, Tsao NL, Judy R, Mitchell BD, Xu H, Montasser ME, et al. Carriers of rare damaging  genetic variants are at lower risk of atherosclerotic disease. medRxiv. 2023  .

Goudis C, Daios S, Dimitriadis F, Liu T. CHARGE-AF: A Useful Score For Atrial Fibrillation Prediction?. Curr Cardiol Rev. 2023  ;19(2):e010922208402.

Kizer JR, Patel S, Ganz P, Newman AB, Bhasin S, Lee S-J, Cawthon PM, LeBrasseur N, Shah SJ, Psaty BM, et al. Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-like-3, and Risk of Heart Failure in Elders. J Gerontol A Biol Sci Med Sci. 2023  .

Tobias DK, Manning AK, Wessel J, Raghavan S, Westerman KE, Bick AG, DiCorpo D, Whitsel EA, Collins J, Correa A, et al. Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. Diabetes Care. 2023  .

Vlasschaert C, Robinson-Cohen C, Kestenbaum B, Silver SA, Chen J-C, Akwo E, Bhatraju PK, Zhang M-Z, Cao S, Jiang M, et al. Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury. medRxiv. 2023  .

Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, et al. Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics. medRxiv. 2023  .

Pershad Y, Mack T, Poisner H, Jakubek YA, Stilp AM, Mitchell BD, Lewis JP, Boerwinkle E, Loos RJ, Chami N, et al. Determinants of mosaic chromosomal alteration fitness. medRxiv. 2023  .

Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, et al. {Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?. Alzheimers Dement (Amst). 2023  ;15:e12482.

Mohebi R, Wang D, Lau ES, Parekh JK, Allen N, Psaty BM, Benjamin EJ, Levy D, Wang TJ, Shah SJ, et al. Effect of 2022 ACC/AHA/HFSA Criteria on Stages of Heart Failure in a Pooled Community Cohort. J Am Coll Cardiol. 2023  ;81(23):2231-2242.

Kurniansyah N, Goodman MO, Khan AT, Wang J, Feofanova E, Bis JC, Wiggins KL, Huffman JE, Kelly T, Elfassy T, et al. Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. Nat Commun. 2023  ;14(1):3202.

Newman AB, Patel S, Kizer J, Lee S-J, Bhasin S, Cawthon P, LeBrasseur N, Tracy RP, Ganz P, Cummings S. Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8 and their Binding Proteins Follistatin and Follistatin-like protein-3 with Dementia and Cognition. J Gerontol A Biol Sci Med Sci. 2023  .

Fuentes Lde Las, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJu, Munroe PB, Miller CL, Aschard H, Aslibekyan S, et al. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Front Genet. 2023  ;14:1235337.

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, Van Duijvenboden S, et al. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nat Commun. 2023  ;14(1):1411.

Einson J, Glinos D, Boerwinkle E, Castaldi P, Darbar D, de Andrade M, Ellinor P, Fornage M, Gabriel S, Germer S, et al. Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants. bioRxiv. 2023  .

Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, et al. The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Sci Adv. 2023  ;9(17):eabm4945.

Yang C, Veenstra J, Bartz T, Pahl M, Hallmark B, Chen Y-DI, Westra J, Steffen L, Brown C, Siscovick D, et al. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. Res Sq. 2023  .

Guirette M, Lan J, McKeown N, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM, Morrison AC, Bartz TM, et al. Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. medRxiv. 2023  .

Cole KL, Boehme AK, Thacker EL, Longstreth WT, Brown BL, Gale SD, Hedges DW, Anderson JK, Elkind MSV. Hospital-Acquired Infection at Time of Stroke and Cognitive Decline: The Cardiovascular Health Study. Cerebrovasc Dis. 2023  .

Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I, Lindbohm JV, Duggan MR, et al. {Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Commun Biol. 2023  ;6:1117.

Frimodt-Møller EK, Gottdiener JS, Soliman EZ, Kizer JR, Vittinghoff E, Psaty BM, Biering-Sørensen T, Marcus GM. Inflammation and Incident Conduction Disease. J Am Heart Assoc. 2023  ;12(1):e027247.

Fan KH, Francis L, M Aslam M, Bedison MA, Lawrence E, Acharya V, Snitz BE, Ganguli M, DeKosky ST, Lopez OL, et al. Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease. Neurobiol Aging. 2023  ;122:107-111.

Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G, Sim X, Yaghootkar H, et al. Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization. Wellcome Open Res. 2023  ;8:483.

Liu F, Austin TR, Schrack JA, Chen J, Walston J, Mathias RA, Grams M, Odden MC, Newman A, Psaty BM, et al. Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis. Aging Cell. 2023  .

Frimodt-Møller EK, Soliman EZ, Kizer JR, Vittinghoff E, Psaty BM, Biering-Sørensen T, Gottdiener JS, Marcus GM. Lifestyle habits associated with cardiac conduction disease. Eur Heart J. 2023  .

Chemparathy A, Guen YL, Chen S, Lee EG, Leong L, Gorzynski J, Xu G, Belloy M, Kasireddy N, Tauber AP, et al. loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology. medRxiv. 2023  .

Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchel BD, Psaty BM, et al. Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores. medRxiv. 2023  .

Jakubek YA, Zhou Y, Stilp A, Bacon J, Wong JW, Ozcan Z, Arnett D, Barnes K, Bis JC, Boerwinkle E, et al. Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing. Nat Genet. 2023  ;55(11):1912-1919.

Kavousi M, Bos MM, Barnes HJ, Cardenas CLLino, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, et al. Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. Nat Genet. 2023  ;55(10):1651-1664.

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Rayner NW, Bocher O, et al. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. medRxiv. 2023  .

Chen F, Wang X, Jang S-K, Quach BC, J Weissenkampen D, Khunsriraksakul C, Yang L, Sauteraud R, Albert CM, Allred NDD, et al. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nat Genet. 2023  ;55(2):291-300.

Sarma AA, Paniagua SM, Lau ES, Wang D, Liu EE, Larson MG, Hamburg NM, Mitchell GF, Kizer J, Psaty BM, et al. Multiple Prior Live Births are Associated with Cardiac Remodeling and Heart Failure Risk in Women. J Card Fail. 2023  .

Godina SL, Rosso AL, Hirsch JA, Besser LM, Lovasi GS, Donovan GH, Garg PK, Platt JM, Fitzpatrick AL, Lopez OL, et al. Neighborhood greenspace and cognition: The cardiovascular health study. Health Place. 2023  ;79:102960.

Besser LM, Lovasi GS, Zambrano JJimenez, Camacho S, Dhanekula D, Michael YL, Garg P, Hirsch JA, Siscovick D, Hurvitz PM, et al. Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study. Alzheimers Dement (Amst). 2023  ;15(4):e12484.

Kalani R, Bartz TM, Psaty BM, Elkind MSV, Floyd JS, Gerszten RE, Shojaie A, Heckbert SR, Bis JC, Austin TR, et al. Plasma Proteomic Associations With Incident Ischemic Stroke in Older Adults: The Cardiovascular Health Study. Neurology. 2023  .

Gharib AR, Jensen PN, Psaty BM, Hoofnagle AN, Siscovick D, Gharib SA, Sitlani CM, Sotoodehnia N, Lemaitre RN. Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study. ERJ Open Res. 2023  ;9(2).

Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins J. {Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease. medRxiv. 2023  .

Lastwika KJ, Kunihiro A, Solan JL, Zhang Y, Taverne LR, Shelley D, Rho J-H, Randolph TW, Li CI, Grogan EL, et al. Posttranslational modifications induce autoantibodies with risk prediction capability in patients with small cell lung cancer. Sci Transl Med. 2023  ;15(678):eadd8469.

Li X, Quick C, Zhou H, Gaynor SM, Liu Y, Chen H, Selvaraj MSunitha, Sun R, Dey R, Arnett DK, et al. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Nat Genet. 2023  ;55(1):154-164.

Sussman JB, Whitney RT, Burke JF, Hayward RA, Galecki A, Sidney S, Allen NBai, Gottesman RF, Heckbert SR, Longstreth WT, et al. Prediction of Multiple Individual Primary Cardiovascular Events Using Pooled Cohorts. medRxiv. 2023  .

Zhou TD, Zhang Z, Balachandrasekaran A, Raji CA, Becker JT, Kuller LH, Ge Y, Lopez OL, Dai W, H Gach M. Prospective Longitudinal Perfusion in Probable Alzheimer's Disease Correlated with Atrophy in Temporal Lobe. Aging Dis. 2023  .

Jonmundsson T, Steindorsdottir AE, Austin TR, Frick EA, Axelsson GT, Launer L, Psaty BM, Loureiro J, Orth AP, Aspelund T, et al. A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study). Europace. 2023  ;25(11).

Emilsson V, Jonsson BG, Austin TR, Gudmundsdottir V, Axelsson GT, Frick EA, Jonmundsson T, Steindorsdottir AE, Loureiro J, Brody JA, et al. Proteomic prediction of incident heart failure and its main subtypes. Eur J Heart Fail. 2023  .

Wang Y, Selvaraj MSunitha, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, et al. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. medRxiv. 2023  .

Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril A-A, Yiallourou S, Bisson A, Himali D, Leng Y, et al. Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults. JAMA Netw Open. 2023  ;6(7):e2325152.

Li X, Chen H, Selvaraj MSunitha, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, et al. A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. bioRxiv. 2023  .

Kwak SHeon, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, et al. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. medRxiv. 2023  .

Massera D, Bartz TM, Biggs ML, Sotoodehnia N, Reiner AP, Semba RD, Gottdiener JS, Psaty BM, Owens DS, Kizer JR. Traditional and novel risk factors for incident aortic stenosis in community-dwelling older adults. Heart. 2023  .

Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, et al. A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies. J Endocr Soc. 2023  ;7(11):bvad123.

Hasbani NR, Westerman KE, Kwak SHeon, Chen H, Li X, DiCorpo D, Wessel J, Bis JC, Sarnowski C, Wu P, et al. Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis. Circ Genom Precis Med. 2023  :e004176.

Huffman JE, Nicolas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, et al. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. medRxiv. 2023  .

Seyerle AA, Laurie CA, Coombes BJ, Jain D, Conomos MP, Brody J, Chen M-H, Gogarten SM, Beutel KM, Gupta N, et al. Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program. Circ Genom Precis Med. 2023  :e003532.

Armstrong ND, Srinivasasainagendra V, Ammous F, Assimes TL, Beitelshees AL, Brody J, Cade BE, Chen Y-DIda, Chen H, de Vries PS, et al. Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program. Front Genet. 2023  ;14:1278215.

Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS, et al. WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE. medRxiv. 2023  .

Jiang M-Z, Gaynor SM, Li X, Van Buren E, Stilp A, Buth E, Wang FFei, Manansala R, Gogarten SM, Li Z, et al. Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) Consortium. bioRxiv. 2023  .

Feofanova EV, Brown MR, Alkis T, Manuel AM, Li X, Tahir UA, Li Z, Mendez KM, Kelly RS, Qi Q, et al. Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations. Nat Commun. 2023  ;14(1):3111.

de Vries PS, Conomos MP, Singh K, Nicholson CJ, Jain D, Hasbani NR, Jiang W, Lee S, Cardenas CLLino, Lutz SM, et al. Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. Nat Cardiovasc Res. 2023  ;2(12):1159-1172.

Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, et al. Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset. medRxiv. 2024  .

Sun X, Bulekova K, Yang J, Lai M, Pitsillides AN, Liu X, Zhang Y, Guo X, Yong Q, Raffield LM, et al. Association analysis of mitochondrial DNA heteroplasmic variants: methods and application. medRxiv. 2024  .

Ji Y, Zhang MJ, Wang W, Norby FL, Eaton AA, Inciardi RM, Alonso A, Sedaghat S, Ganz P, Hof JVan't, et al. Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS. Circulation. 2024  .

Barasch E, Gottdiener J, B?zková P, Cappola A, Shah S, DeFilippi C, Gardin J, Kizer JR. Association of thyroid dysfunction in individuals???65 years of age with subclinical cardiac abnormalities. J Clin Endocrinol Metab. 2024  .

Duong TV, Austin TR, Brody JA, Shojaie A, Battle A, Bader JS, Hong YSoo, Ballantyne CM, Coresh J, Gerszten RE, et al. Circulating Blood Plasma Profiling Reveals Proteomic Signature and a Causal Role for SVEP1 in Sudden Cardiac Death. Circ Genom Precis Med. 2024  :e004494.

Gutierrez-Tordera L, Moseholm KF, Trius-Soler M, Bulló M, Fitzpatrick A, Connelly MA, Lopez OL, Jensen MK, Guasch-Ferré M, Mukamal KJ. Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia. Aging Dis. 2024  .

Krefman AE, Stephen J, Carolan P, Sedaghat S, Mansolf M, Soumare A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, et al. {Cohort Profile: Dementia Risk Prediction Project (DRPP). Int J Epidemiol. 2024  ;53.

Zhu J, Jhang J, Yu H, Mushlin AI, Kamel H, Alemayehu N, Giardina JC, Gupta A, Pandya A. Cost-Effectiveness of Screening Asymptomatic Carotid Stenosis by Atherosclerotic Cardiovascular Risk. medRxiv. 2024  .

Khan SS, Matsushita K, Sang Y, Ballew SH, Grams ME, Surapaneni A, Blaha MJ, Carson AP, Chang AR, Ciemins E, et al. Development and Validation of the American Heart Association's PREVENT Equations. Circulation. 2024  ;149(6):430-449.

Mack TM, Raddatz MA, Pershad Y, Nachun DC, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Kenny EE, Loos RJF, et al. Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate. Nat Aging. 2024  .

Huang Y-J, Kurniansyah N, Goodman MO, Spitzer BW, Wang J, Stilp A, Laurie C, de Vries PS, Chen H, Min Y-I, et al. The expected polygenic risk score (ePRS) framework: an equitable metric for quantifying polygenetic risk via modeling of ancestral makeup. medRxiv. 2024  .

Zhang Y, Dron JS, Bellows BK, Khera AV, Liu J, Balte PP, Oelsner EC, Amr SSamir, Lebo MS, Nagy A, et al. Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol. JAMA Cardiol. 2024  .

Nagarajan P, Kurniansyah N, Lee J, Gharib SA, Xu Y, Zhang Y, Spitzer B, Faquih T, Zhou H, Boerwinkle E, et al. Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype. medRxiv. 2024  .

de Vries PS, Reventun P, Brown MR, Heath AS, Huffman JE, Le NQ, Bebo A, Brody JA, Temprano-Sagrera G, Raffield LM, et al. {A genetic association study of circulating coagulation Factor VIII and von Willebrand Factor levels. Blood. 2024  .

Katsumata Y, Fardo DW, Shade LMP, Wu X, Karanth SD, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Gauthreaux K, et al. {Genetic associations with dementia-related proteinopathy: Application of item response theory. Alzheimers Dement. 2024  .

Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, et al. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia. JAMA Netw Open. 2024  ;7(5):e2412824.

Weinstock JS, Chaudhry SA, Ioannou M, Viskadourou M, Reventun P, Jakubek YA, L Liggett A, Laurie C, Broome JG, Khan A, et al. The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations. medRxiv. 2024  .

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024  .

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E, Hellwege JN, Yengo L, et al. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat Genet. 2024  .

Higbee DH, Lirio A, Hamilton F, Granell R, Wyss AB, London SJ, Bartz TM, Gharib SA, Cho MH, Wan E, et al. {Genome-wide association study of preserved ratio impaired spirometry (PRISm). Eur Respir J. 2024  ;63.

Yu Z, Vromman A, Nguyen NQuynh H, Schuermans A, Rentz T, Vellarikkal SK, Uddin MMesbah, Niroula A, Griffin G, Honigberg MC, et al. Human Plasma Proteomic Profile of Clonal Hematopoiesis. bioRxiv. 2024  .

Leung YYee, Naj AC, Chou Y-F, Valladares O, Schmidt M, Hamilton-Nelson K, Wheeler N, Lin H, Gangadharan P, Qu L, et al. Human whole-exome genotype data for Alzheimer's disease. Nat Commun. 2024  ;15(1):684.

Sharma S, Katz R, Chaves PHM, Hoofnagle AN, Kizer JR, Bansal N, Ganz T, Ix JH. Iron Deficiency and Incident Heart Failure in Older Community-Dwelling Individuals. ESC Heart Fail. 2024  .

Austin TR, Fink HA, Jalal DI, Törnqvist AE, B?zková P, Barzilay JI, Lu T, Carbone L, Gabrielsen ME, Grahnemo L, et al. Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures. J Bone Miner Res. 2024  .

Wang H, Nagarajan P, Winkler T, Bentley A, Miller C, Kraja A, Schwander K, Lee S, Wang W, Brown M, et al. A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. Res Sq. 2024  .

Nagarajan P, Winkler TW, Bentley AR, Miller CL, Kraja AT, Schwander K, Lee S, Wang W, Brown MR, Morrison JL, et al. A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. medRxiv. 2024  .

Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchell BD, Psaty BM, et al. Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores. Sci Rep. 2024  ;14(1):12436.

Lundin JI, Peters U, Hu Y, Ammous F, Avery CL, Benjamin EJ, Bis JC, Brody JA, Carlson C, Cushman M, et al. Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations. Epigenetics. 2024  ;19(1):2333668.

Patchen BK, Zhang J, Gaddis N, Bartz TM, Chen J, Debban C, Leonard H, Nguyen NQ, Seo J, Tern C, et al. {Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline. medRxiv. 2024  .

Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Guare L, Lucas A, Collins DW, Vrathasha V, Nair RM, et al. A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma. Cell. 2024  ;187(2):464-480.e10.

Mei H, Simino J, Li L, Jiang F, Bis JC, Davies G, W Hill D, Xia C, Gudnason V, Yang Q, et al. Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance. Alzheimers Res Ther. 2024  ;16(1):14.

Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O, Andreasen L, Astrup A, et al. {Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nat Commun. 2024  ;15:888.

Kuzma A, Valladares O, Greenfest-Allen E, Nicaretta H, Kirsch M, Ren Y, Katanic Z, White H, Wilk A, Bass L, et al. NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research. medRxiv. 2024  .

Austin TR, Nethander M, Fink HA, Törnqvist AE, Jalal DI, B?zková P, Barzilay JI, Carbone L, Gabrielsen ME, Grahnemo L, et al. A plasma protein-based risk score to predict hip fractures. Nat Aging. 2024  .

Gomez GT, Shi L, Fohner AE, Chen J, Yang Y, Fornage M, Duggan MR, Peng Z, Daya GN, Tin A, et al. Plasma proteome-wide analysis of cerebral small vessel disease identifies novel biomarkers and disease pathways. medRxiv. 2024  .

Liu X, Axelsson GThor, Newman AB, Psaty BM, Boudreau RM, Wu C, Arnold AM, Aspelund T, Austin TR, Gardin JM, et al. Plasma proteomic signature of human longevity. Aging Cell. 2024  :e14136.

Debette S, Caro I, Western D, Namba S, Sun N, Kawaguchi S, He Y, Fujita M, Roshchupkin G, D'Aoust T, et al. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. Res Sq. 2024  .

Laguzzi F, Åkesson A, Marklund M, Qian F, Gigante B, Bartz TM, Bassett JK, Birukov A, Campos H, Hirakawa Y, et al. Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies. Circulation. 2024  ;149(4):305-316.

Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, et al. {The Role of X Chromosome in Alzheimer's Disease Genetics. medRxiv. 2024  .

Yiallourou S, Baril A-A, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, et al. Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium. medRxiv. 2024  .

Kwak SHeon, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, et al. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care. 2024  .

Shore S, Li H, Zhang M, Whitney R, Gross AL, Bhatt AS, Nallamothu BK, Giordani B, Briceño EM, Sussman JB, et al. Trajectory of Cognitive Function After Incident Heart Failure. medRxiv. 2024  .

Tan MCB, Isom CA, Liu Y, Trégouët D-A, Wu L, Zhou D, Gamazon ER. Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism. EBioMedicine. 2024  ;106:105233.

Scholz M, Horn K, Pott J, Wuttke M, Kühnapfel A, M Nasr K, Kirsten H, Li Y, Hoppmann A, Gorski M, et al. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nat Commun. 2024  ;15(1):586.

Shetty NS, Gaonkar M, Pampana A, Patel N, Morrison AC, Reiner AP, Carson AP, Yu B, Psaty BM, Kooperberg C, et al. Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers. JACC Heart Fail. 2025  ;13(1):91-101.

Yaqub A, Bis JC, Frenzel S, Koini M, Mbangdadji D, Peloso GM, Talluri R, Alonso A, Bahls M, Bülow R, et al. Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies. Neurology. 2025  ;104(8):e213421.

Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Mälarstig A, et al. Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Nat Genet. 2025  .

Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett DK, Barnes K, et al. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood. Am J Hum Genet. 2025  ;112(2):276-290.

Weng L-C, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AWeber, Morrill VN, Wang X, Nauffal V, Sun YV, et al. The impact of common and rare genetic variants on bradyarrhythmia development. Nat Genet. 2025  ;57(1):53-64.

Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison J, Schwander K, Westerman K, Kho M, et al. A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations. Res Sq. 2025  .

Nagarajan P, Winkler TW, Bentley AR, Miller CL, Kraja AT, Schwander K, Lee S, Wang W, Brown MR, Morrison JL, et al. A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations. Mol Psychiatry. 2025  .

Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SHoan, Holm H, Chaffin M, Gudbjartsson D, Hill MC, et al. Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Nat Genet. 2025  ;57(3):539-547.

Hu Y, Haessler J, Lundin JI, Darst BF, Whitsel EA, Grove M, Guan W, Xia R, Szeto M, Raffield LM, et al. Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants. Clin Epigenetics. 2025  ;17(1):54.

Bortnick AE, Austin TR, Hamerton E, Gudmundsdottir V, Emilsson V, Jennings LL, Gudnason V, Owens DS, Massera D, Dufresne L, et al. Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults. J Am Heart Assoc. 2025  ;14(5):e036336.

Georgakis MK, Malik R, Bounkari OEl, Hasbani NR, Li J, Huffman JE, Shakt G, Tack RWP, Kimball TN, Asare Y, et al. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome Med. 2025  ;17(1):27.

Yang D, Zhou D, Cai S, Gan Z, Pencina M, Avillach P, Cai T, Hong C. Robust Automated Harmonization of Heterogeneous Data Through Ensemble Machine Learning: Algorithm Development and Validation Study. JMIR Med Inform. 2025  ;13:e54133.

Choi SHoan, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng L-C, Pirruccello JP, et al. Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Nat Genet. 2025  ;57(3):548-562.

Li X, Chen H, Selvaraj MSunitha, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang M-Z, et al. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Nat Comput Sci. 2025  ;5(2):125-143.