Longstreth WT, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O'Leary D, Fried L. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996  ;27(8):1274-82.

Heckbert SR, Longstreth WT, Psaty BM, Murros KE, Smith NL, Newman AB, Williamson JD, Bernick C, Furberg CD. The association of antihypertensive agents with MRI white matter findings and with Modified Mini-Mental State Examination in older adults. J Am Geriatr Soc. 1997  ;45(12):1423-33.

Yue NC, Longstreth WT, Elster AD, Jungreis CA, O'Leary DH, Poirier VC. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology. 1997  ;202(1):41-6.

Yue NC, Arnold AM, Longstreth WT, Elster AD, Jungreis CA, O'Leary DH, Poirier VC, Bryan RN. Sulcal, ventricular, and white matter changes at MR imaging in the aging brain: data from the cardiovascular health study. Radiology. 1997  ;202(1):33-9.

Longstreth WT, Shemanski L, Lefkowitz D, O'Leary DH, Polak JF, Wolfson SK. Asymptomatic internal carotid artery stenosis defined by ultrasound and the risk of subsequent stroke in the elderly. The Cardiovascular Health Study. Stroke. 1998  ;29(11):2371-6.

Longstreth WT. Brain abnormalities in the elderly: frequency and predictors in the United States (the Cardiovascular Health Study). Cardiovascular Health Study Collaborative Research Group. J Neural Transm Suppl. 1998  ;53:9-16.

Longstreth WT, Bernick C, Manolio TA, Bryan N, Jungreis CA, Price TR. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol. 1998  ;55(9):1217-25.

Longstreth WT, Arnold AM, Manolio TA, Burke GL, Bryan N, Jungreis CA, O'Leary D, Enright PL, Fried L. Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people. The Cardiovascular Health Study. Collaborative Research Group. Neuroepidemiology. 2000  ;19(1):30-42.

Mukamal KJ, Longstreth WT, Mittleman MA, Crum RM, Siscovick DS. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke. 2001  ;32(9):1939-46.

Longstreth WT, Diehr P, Manolio TA, Beauchamp NJ, Jungreis CA, Lefkowitz D. Cluster analysis and patterns of findings on cranial magnetic resonance imaging of the elderly: the Cardiovascular Health Study. Arch Neurol. 2001  ;58(4):635-40.

Longstreth WT, Bernick C, Fitzpatrick A, Cushman M, Knepper L, Lima J, Furberg CD. Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study. Neurology. 2001  ;56(3):368-75.

Longstreth WT, Diehr P, Beauchamp NJ, Manolio TA. Patterns on cranial magnetic resonance imaging in elderly people and vascular disease outcomes. Arch Neurol. 2001  ;58(12):2074.

Bernick C, Kuller L, Dulberg C, Longstreth WT, Manolio T, Beauchamp N, Price T. Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology. 2001  ;57(7):1222-9.

Longstreth WT, Dulberg C, Manolio TA, Lewis MR, Beauchamp NJ, O'Leary D, Carr J, Furberg CD. Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke. 2002  ;33(10):2376-82.

Ding J, F Nieto J, Beauchamp NJ, Longstreth WT, Manolio TA, Hetmanski JB, Fried LP. A prospective analysis of risk factors for white matter disease in the brain stem: the Cardiovascular Health Study. Neuroepidemiology. 2003  ;22(5):275-82.

Mukamal KJ, Kuller LH, Fitzpatrick AL, Longstreth WT, Mittleman MA, Siscovick DS. Prospective study of alcohol consumption and risk of dementia in older adults. JAMA. 2003  ;289(11):1405-13.

S Johnston C, O'Meara ES, Manolio TA, Lefkowitz D, O'Leary DH, Goldstein S, Carlson MC, Fried LP, Longstreth WT. Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Ann Intern Med. 2004  ;140(4):237-47.

Longstreth WT, Katz R, Olson J, Bernick C, J Carr J, M Malinow R, Hess DL, Cushman M, Schwartz SM. Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health Study. Arch Neurol. 2004  ;61(1):67-72.

Mukamal KJ, Mittleman MA, Longstreth WT, Newman AB, Fried LP, Siscovick DS. Self-reported alcohol consumption and falls in older adults: cross-sectional and longitudinal analyses of the cardiovascular health study. J Am Geriatr Soc. 2004  ;52(7):1174-9.

Elkins JS, O'Meara ES, Longstreth WT, Carlson MC, Manolio TA, Johnston SC. Stroke risk factors and loss of high cognitive function. Neurology. 2004  ;63(5):793-9.

Kuller LH, Longstreth WT, Arnold AM, Bernick C, R Bryan N, Beauchamp NJ. White matter hyperintensity on cranial magnetic resonance imaging: a predictor of stroke. Stroke. 2004  ;35(8):1821-5.

Mukamal KJ, Chung H, Jenny NS, Kuller LH, Longstreth WT, Mittleman MA, Burke GL, Cushman M, Beauchamp NJ, Siscovick DS. Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study. Stroke. 2005  ;36(9):1830-4.

Seliger SL, Longstreth WT, Katz R, Manolio T, Fried LF, Shlipak M, Stehman-Breen CO, Newman A, Sarnak M, Gillen DL, et al. Cystatin C and subclinical brain infarction. J Am Soc Nephrol. 2005  ;16(12):3721-7.

Mozaffarian D, Longstreth WT, Lemaitre RN, Manolio TA, Kuller LH, Burke GL, Siscovick DS. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med. 2005  ;165(2):200-6.

Longstreth WT, Arnold AM, Beauchamp NJ, Manolio TA, Lefkowitz D, Jungreis C, Hirsch CH, O'Leary DH, Furberg CD. Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke. 2005  ;36(1):56-61.

Kaplan RC, Tirschwell DL, Longstreth WT, Manolio TA, Heckbert SR, Lefkowitz D, El-Saed A, Psaty BM. Vascular events, mortality, and preventive therapy following ischemic stroke in the elderly. Neurology. 2005  ;65(6):835-42.

Mukamal KJ, Chung H, Jenny NS, Kuller LH, Longstreth WT, Mittleman MA, Burke GL, Cushman M, Psaty BM, Siscovick DS. Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 2006  ;54(1):30-7.

Kaplan RC, Tirschwell DL, Longstreth WT, Manolio TA, Heckbert SR, LeValley AJ, Lefkowitz D, El-Saed A, Psaty BM. Blood pressure level and outcomes in adults aged 65 and older with prior ischemic stroke. J Am Geriatr Soc. 2006  ;54(9):1309-16.

Elkins JS, Longstreth WT, Manolio TA, Newman AB, Bhadelia RA, Johnston SC. Education and the cognitive decline associated with MRI-defined brain infarct. Neurology. 2006  ;67(3):435-40.

Rosano C, Brach J, Studenski S, Longstreth WT, Newman AB. Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults. Neuroepidemiology. 2007  ;29(3-4):193-200.

Sturgeon JD, Folsom AR, Longstreth WT, Shahar E, Rosamond WD, Cushman M. Risk factors for intracerebral hemorrhage in a pooled prospective study. Stroke. 2007  ;38(10):2718-25.

Kuller LH, Arnold AM, Longstreth WT, Manolio TA, O'Leary DH, Burke GL, Fried LP, Newman AB. White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study. Neurobiol Aging. 2007  ;28(9):1307-15.

Steffens DC, Chung H, K Krishnan RR, Longstreth WT, Carlson M, Burke GL. Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke. 2008  ;39(3):857-62.

Fornage M, Y Chiang A, O'Meara ES, Psaty BM, Reiner AP, Siscovick DS, Tracy RP, Longstreth WT. Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study. Stroke. 2008  ;39(7):1952-9.

Virtanen JK, Siscovick DS, Longstreth WT, Kuller LH, Mozaffarian D. Fish consumption and risk of subclinical brain abnormalities on MRI in older adults. Neurology. 2008  ;71(6):439-46.

Sturgeon JD, Folsom AR, Longstreth WT, Shahar E, Rosamond WD, Cushman M. Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort. Stroke. 2008  ;39(8):2268-73.

Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT, Lumley T, Rice K, Tracy RP, et al. Gene variants associated with ischemic stroke: the cardiovascular health study. Stroke. 2009  ;40(2):363-8.

Ikram AM, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, et al. Genomewide association studies of stroke. N Engl J Med. 2009  ;360(17):1718-28.

Fitzpatrick AL, Kuller LH, Lopez OL, Diehr P, O'Meara ES, Longstreth WT, Luchsinger JA. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch Neurol. 2009  ;66(3):336-42.

Aguilar MI, O'Meara ES, Seliger S, Longstreth WT, Hart RG, Pergola PE, Shlipak MG, Katz R, Sarnak MJ, Rifkin DE. Albuminuria and the risk of incident stroke and stroke types in older adults. Neurology. 2010  ;75(15):1343-50.

Welmerink DB, Longstreth WT, Lyles MF, Fitzpatrick AL. Cognition and the risk of hospitalization for serious falls in the elderly: results from the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2010  ;65(11):1242-9.

Seshadri S, Fitzpatrick AL, Ikram AM, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JCharles, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010  ;303(18):1832-40.

Debette S, Bis JC, Fornage M, Schmidt H, Ikram AM, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, et al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke. 2010  ;41(2):210-7.

Longstreth WT, Katz R, Tirschwell DL, Cushman M, Psaty BM. Intravenous tissue plasminogen activator and stroke in the elderly. Am J Emerg Med. 2010  ;28(3):359-63.

Ton TG, Jain S, Boudreau R, Thacker EL, Strotmeyer ES, Newman AB, Longstreth WT, Checkoway H. Post hoc Parkinson's disease: identifying an uncommon disease in the Cardiovascular Health Study. Neuroepidemiology. 2010  ;35(4):241-9.

Rodriguez CJ, Bartz TM, Longstreth WT, Kizer JR, Barasch E, Lloyd-Jones DM, Gottdiener JS. Association of annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults: the cardiovascular health study. J Am Coll Cardiol. 2011  ;57(21):2172-80.

Zakai NA, Lange L, Longstreth WT, O'Meara ES, Kelley JL, Fornage M, Nikerson D, Cushman M, Reiner AP. Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study. J Thromb Haemost. 2011  ;9(2):267-74.

Folsom AR, Yatsuya H, Psaty BM, Shahar E, Longstreth WT. Carotid intima-media thickness, electrocardiographic left ventricular hypertrophy, and incidence of intracerebral hemorrhage. Stroke. 2011  ;42(11):3075-9.

Thacker EL, Psaty BM, McKnight B, Heckbert SR, Longstreth WT, Mukamal KJ, Meigs JB, de Boer IH, Boyko EJ, Carnethon MR, et al. Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults. Stroke. 2011  ;42(12):3347-51.

Arab L, Biggs ML, O'Meara ES, Longstreth WT, Crane PK, Fitzpatrick AL. Gender differences in tea, coffee, and cognitive decline in the elderly: the Cardiovascular Health Study. J Alzheimers Dis. 2011  ;27(3):553-66.

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang S-J, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011  ;478(7367):103-9.

Fornage M, Debette S, Bis JC, Schmidt H, Ikram AM, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, et al. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol. 2011  ;69(6):928-39.

Elkind MSV, Carty CL, O'Meara ES, Lumley T, Lefkowitz D, Kronmal RA, Longstreth WT. Hospitalization for infection and risk of acute ischemic stroke: the Cardiovascular Health Study. Stroke. 2011  ;42(7):1851-6.

Kizer JR, Biggs ML, Ix JH, Mukamal KJ, Zieman SJ, de Boer IH, Mozaffarian D, Barzilay JI, Strotmeyer ES, Luchsinger JA, et al. Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women. Am J Epidemiol. 2011  ;173(1):10-25.

Brown AF, Liang L-J, Vassar SD, Stein-Merkin S, Longstreth WT, Ovbiagele B, Yan T, Escarce JJ. Neighborhood disadvantage and ischemic stroke: the Cardiovascular Health Study (CHS). Stroke. 2011  ;42(12):3363-8.

Longstreth WT, Arnold AM, Kuller LH, Bernick C, Lefkowitz DS, Beauchamp NJ, Manolio TA. Progression of magnetic resonance imaging-defined brain vascular disease predicts vascular events in elderly: the Cardiovascular Health Study. Stroke. 2011  ;42(10):2970-2.

Jain S, Ton TG, Boudreau RM, Yang M, Thacker EL, Studenski S, Longstreth WT, Strotmeyer ES, Newman AB. The risk of Parkinson disease associated with urate in a community-based cohort of older adults. Neuroepidemiology. 2011  ;36(4):223-9.

Ton TGN, Jain S, Biggs ML, Thacker EL, Strotmeyer ES, Boudreau R, Newman AB, Longstreth WT, Checkoway H. Markers of inflammation in prevalent and incident Parkinson's disease in the Cardiovascular Health Study. Parkinsonism Relat Disord. 2012  ;18(3):274-8.

Folsom AR, Yatsuya H, Mosley TH, Psaty BM, Longstreth WT. Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarcts. Ann Neurol. 2012  ;71(4):552-9.

Thacker EL, McKnight B, Psaty BM, Longstreth WT, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013  ;81(2):119-25.

Suchy-Dicey AM, Wallace ER, Mitchell SVElkind, Aguilar M, Gottesman RF, Rice K, Kronmal R, Psaty BM, Longstreth WT. Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study. Am J Hypertens. 2013  ;26(10):1210-7.

Yan T, Escarce JJ, Liang L-J, Longstreth WT, Merkin SStein, Ovbiagele B, Vassar SD, Seeman T, Sarkisian C, Brown AF. Exploring psychosocial pathways between neighbourhood characteristics and stroke in older adults: the cardiovascular health study. Age Ageing. 2013  ;42(3):391-7.

Smith LG, Yatsuya H, Psaty BM, Longstreth WT, Folsom AR. Height and risk of incident intraparenchymal hemorrhage: Atherosclerosis Risk in Communities and Cardiovascular Health study cohorts. J Stroke Cerebrovasc Dis. 2013  ;22(4):323-8.

Brown AF, Liang L-J, Vassar SD, Merkin SStein, Longstreth WT, Ovbiagele B, Yan T, Escarce JJ. Neighborhood socioeconomic disadvantage and mortality after stroke. Neurology. 2013  ;80(6):520-7.

Mahmoodi BK, Yatsuya H, Matsushita K, Sang Y, Gottesman RF, Astor BC, Woodward M, Longstreth WT, Psaty BM, Shlipak MG, et al. Association of kidney disease measures with ischemic versus hemorrhagic strokes: pooled analyses of 4 prospective community-based cohorts. Stroke. 2014  ;45(7):1925-31.

Bis JC, DeStefano A, Liu X, Brody JA, Choi SHoan, Verhaaren BFJ, Debette S, Ikram AM, Shahar E, Butler KR, et al. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014  ;9(6):e99798.

Longstreth WT, Diehr PH, Yee LM, Newman AB, Beauchamp NJ. Brain imaging findings in elderly adults and years of life, healthy life, and able life over the ensuing 16 years: the Cardiovascular Health Study. J Am Geriatr Soc. 2014  ;62(10):1838-43.

Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SHoan, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ, et al. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke. 2014  ;45(2):403-12.

Ferket BS, van Kempen BJH, Wieberdink RG, Steyerberg EW, Koudstaal PJ, Hofman A, Shahar E, Gottesman RF, Rosamond W, Kizer JR, et al. Separate prediction of intracerebral hemorrhage and ischemic stroke. Neurology. 2014  ;82(20):1804-12.

Shores MM, Arnold AM, Biggs ML, Longstreth WT, Smith NL, Kizer JR, Cappola AR, Hirsch CH, Marck BT, Matsumoto AM. Testosterone and dihydrotestosterone and incident ischaemic stroke in men in the Cardiovascular Health Study. Clin Endocrinol (Oxf). 2014  ;81(5):746-53.

Shores MM, Biggs ML, Arnold AM, Smith NL, Longstreth WT, Kizer JR, Hirsch CH, Cappola AR, Matsumoto AM. Testosterone, dihydrotestosterone, and incident cardiovascular disease and mortality in the cardiovascular health study. J Clin Endocrinol Metab. 2014  ;99(6):2061-8.

Kamel H, Bartz TM, Longstreth WT, Okin PM, Thacker EL, Patton KK, Stein PK, Gottesman RF, Heckbert SR, Kronmal RA, et al. Association between left atrial abnormality on ECG and vascular brain injury on MRI in the Cardiovascular Health Study. Stroke. 2015  ;46(3):711-6.

Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, et al. Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study. J Thromb Haemost. 2015  ;13(10):1867-77.

Debette S, Verbaas CAIbrahim, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, et al. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015  ;77(8):749-63.

Carty CL, Keene KL, Cheng Y-C, Meschia JF, Chen W-M, Nalls M, Bis JC, Kittner SJ, Rich SS, Tajuddin S, et al. Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. Stroke. 2015  ;46(8):2063-8.

Verhaaren BFJ, Debette S, Bis JC, Smith JA, M Ikram K, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, et al. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet. 2015  ;8(2):398-409.

Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, H Gach M, Longstreth WT, Teverovskiy L, Kuller LH, Carmichael OT, et al. Physical activity, body mass index, and brain atrophy in Alzheimer's disease. Neurobiol Aging. 2015  ;36 Suppl 1:S194-S202.

Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, et al. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol. 2015  ;72(7):781-8.

Malik R, Freilinger T, Winsvold BS, Anttila V, Heiden JVander, Traylor M, de Vries B, Holliday EG, Terwindt GM, Sturm J, et al. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology. 2015  ;84(21):2132-45.

Flatt JD, Rosso AL, Aizenstein HJ, Schulz R, Longstreth WT, Newman AB, Fowler NR, Rosano C. Social Network Size and Cranial Magnetic Resonance Imaging Findings in Older Adults: The Cardiovascular Health Study. J Am Geriatr Soc. 2015  ;63(11):2430-2.

Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BFJ, Wolf C, et al. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences. Stroke. 2015  ;46(11):3048-57.

Kwon Y, Norby FL, Jensen PN, Agarwal SK, Soliman EZ, Lip GYH, Longstreth WT, Alonso A, Heckbert SR, Chen LY. Association of Smoking, Alcohol, and Obesity with Cardiovascular Death and Ischemic Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS). PLoS One. 2016  ;11(1):e0147065.

Gilsanz P, Kubzansky LD, Tchetgen EJTchetgen, Wang Q, Kawachi I, Patton KK, Fitzpatrick AL, Kop WJ, Longstreth WT, M Glymour M. Changes in Depressive Symptoms and Subsequent Risk of Stroke in the Cardiovascular Health Study. Stroke. 2016  .

Cheng Y-C, Stanne TM, Giese A-K, Ho WKee, Traylor M, Amouyel P, Holliday EG, Malik R, Xu H, Kittner SJ, et al. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke. 2016  ;47(2):307-16.

Raji CA, Merrill DA, Eyre H, Mallam S, Torosyan N, Erickson KI, Lopez OL, Becker JT, Carmichael OT, H Gach M, et al. Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study. J Alzheimers Dis. 2016  ;52(2):719-29.

Soares-Miranda L, Siscovick DS, Psaty BM, Longstreth WT, Mozaffarian D. Physical Activity and Risk of Coronary Heart Disease and Stroke in Older Adults: The Cardiovascular Health Study. Circulation. 2016  ;133(2):147-55.

Psaty BM, Delaney JA, Arnold AM, Curtis LH, Fitzpatrick AL, Heckbert SR, McKnight B, Ives D, Gottdiener JS, Kuller LH, et al. Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study. Circulation. 2016  ;133(2):156-64.

Chaker L, Baumgartner C, Elzen WPJ den, Collet T-H, Ikram AM, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies MLP, et al. Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2016  ;101(11):4270-4282.

Leung LY, Bartz TM, Rice K, Floyd J, Psaty B, Gutierrez J, Longstreth WT, Mukamal KJ. Blood Pressure and Heart Rate Measures Associated With Increased Risk of Covert Brain Infarction and Worsening Leukoaraiosis in Older Adults. Arterioscler Thromb Vasc Biol. 2017  ;37(8):1579-1586.

Dhamoon MS, Longstreth WT, Bartz TM, Kaplan RC, Elkind MSV. Disability Trajectories Before and After Stroke and Myocardial Infarction: The Cardiovascular Health Study. JAMA Neurol. 2017  ;74(12):1439-1445.

Saber H, Yakoob MYawar, Shi P, Longstreth WT, Lemaitre RN, Siscovick D, Rexrode KM, Willett WC, Mozaffarian D. Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts. Stroke. 2017  ;48(10):2678-2685.

Choi H, Pack A, Elkind MSV, Longstreth WT, Ton TGN, Onchiri F. Predictors of incident epilepsy in older adults: The Cardiovascular Health Study. Neurology. 2017  ;88(9):870-877.

Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP. Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk. J Thromb Haemost. 2018  ;16(1):19-30.

Kamel H, Bartz TM, Elkind MSV, Okin PM, Thacker EL, Patton KK, Stein PK, deFilippi CR, Gottesman RF, Heckbert SR, et al. Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study). Stroke. 2018  ;49(4):980-986.

Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu F-C, Nho K, Hofer E, Hagenaars SP, et al. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in  for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. Stroke. 2018  .

Vojinovic D, Adams HH, Jian X, Yang Q, Smith AVernon, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018  ;9(1):3945.

Yaghi S, Bartz TM, Kronmal R, Kamel H, Gottdiener J, Longstreth WT, Elkind MSV. Left atrial diameter and vascular brain injury on MRI: The Cardiovascular Health Study. Neurology. 2018  .

Hammond CA, Blades NJ, Chaudhry SI, Dodson JA, Longstreth WT, Heckbert SR, Psaty BM, Arnold AM, Dublin S, Sitlani CM, et al. Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circ Heart Fail. 2018  ;11(3):e004476.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese A-K, van der Laan SW, Gretarsdottir S, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018  ;50(4):524-537.

Dhand A, Longstreth WT, Chaves PHM, Dhamoon MS. Social Network Trajectories in Myocardial Infarction Versus Ischemic Stroke. J Am Heart Assoc. 2018  ;7(8).

Mishra A, Chauhan G, Violleau M-H, Vojinovic D, Jian X, Bis JC, Li S, Saba Y, Grenier-Boley B, Yang Q, et al. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019  .

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A?, tau, immunity and lipid processing. Nat Genet. 2019  ;51(3):414-430.

Pase MP, Himali JJ, Beiser AS, DeCarli C, McGrath ER, Satizabal CL, Aparicio HJ, Adams HHH, Reiner AP, Longstreth WT, et al. Association of CD14 with incident dementia and markers of brain aging and injury. Neurology. 2020  ;94(3):e254-e266.

Kalani R, Bartz TM, Suchy-Dicey A, Elkind MSV, Psaty BM, Leung LY, Rice K, Tirschwell D, Longstreth WT. Cholesterol Variability and Cranial Magnetic Resonance Imaging Findings in Older Adults: The Cardiovascular Health Study. Stroke. 2020  ;51(1):69-74.

Rohmann JL, Longstreth WT, Cushman M, Fitzpatrick AL, Heckbert SR, Rice K, Rosendaal FR, Sitlani CM, Psaty BM, Siegerink B. Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study. PLoS One. 2020  ;15(11):e0242062.

Juraschek SP, Longstreth WT, Lopez OL, Gottdiener JS, Lipsitz LA, Kuller LH, Mukamal KJ. Orthostatic Hypotension, Dizziness, Neurology Outcomes, and Death in Older Adults. Neurology. 2020  .

Murthy SB, Zhang C, Diaz I, Levitan EB, Koton S, Bartz TM, DeRosa JT, Strobino K, Colantonio LD, Iadecola C, et al. Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies. JAMA Neurol. 2021  ;78(7):809-816.

Besser LM, Lovasi GS, Michael YL, Garg P, Hirsch JA, Siscovick D, Hurvitz P, Biggs ML, Galvin JE, Bartz TM, et al. Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study. Soc Psychiatry Psychiatr Epidemiol. 2021  .

Huang NK, B?zková P, Matthan NR, Djoussé L, Hirsch CH, Kizer JR, Longstreth WT, Mukamal KJ, Lichtenstein AH. Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort. J Am Heart Assoc. 2021  ;10(6):e019135.

Sofer T, Lee J, Kurniansyah N, Jain D, Laurie CA, Gogarten SM, Conomos MP, Heavner B, Hu Y, Kooperberg C, et al. BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion. HGG Adv. 2021  ;2(3).

Koch M, Aroner SA, Fitzpatrick AL, Longstreth WT, Furtado JD, Mukamal KJ, Jensen MK. HDL (High-Density Lipoprotein) Subspecies, Prevalent Covert Brain Infarcts, and Incident Overt Ischemic Stroke: Cardiovascular Health Study. Stroke. 2021  :STROKEAHA121034299.

Huang NK, Biggs ML, Matthan NR, Djoussé L, Longstreth WT, Mukamal KJ, Siscovick DS, Lichtenstein AH. Serum Nonesterified Fatty Acids and Incident Stroke: The CHS. J Am Heart Assoc. 2021  ;10(22):e022725.

Merkler AE, Bartz TM, Kamel H, Soliman EZ, Howard V, Psaty BM, Okin PM, Safford MM, Elkind MSV, Longstreth WT. Silent Myocardial Infarction and Subsequent Ischemic Stroke in the Cardiovascular Health Study. Neurology. 2021  .

Fohner AE, Bartz TM, Tracy RP, Adams HHH, Bis JC, Djoussé L, Satizabal CL, Lopez OL, Seshadri S, Mukamal KJ, et al. Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study. Neurology. 2022  ;98(9):e903-e911.

Frenzel S, Bis JC, Gudmundsson EF, O'Donnell A, Simino J, Yaqub A, Bartz TM, Brusselle GGO, Bülow R, DeCarli CS, et al. Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis. J Alzheimers Dis. 2022  .

Yang Y, Knol MJ, Wang R, Mishra A, Liu D, Luciano M, Teumer A, Armstrong N, Bis JC, Jhun MA, et al. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. Brain. 2022  .

Choi H, Elkind MSV, Longstreth WT, Boehme AK, Hafen R, Hoyt EJ, Thacker EL. Epilepsy, Vascular Risk Factors, and Cognitive Decline in Older Adults: The Cardiovascular Health Study. Neurology. 2022  ;99(21):e2346-e2358.

Liang L-J, Casillas A, Longstreth WT, PhanVo L, Vassar SD, Brown AF. Fishing for health: Neighborhood variation in fish intake, fish quality and association with stroke risk among older adults in the Cardiovascular Health Study. Nutr Metab Cardiovasc Dis. 2022  .

Hwang PH, Longstreth WT, Thielke SM, Francis CE, Carone M, Kuller LH, Fitzpatrick AL. Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States. JAMA Netw Open. 2022  ;5(5):e2210734.

Austin TR, McHugh CP, Brody JA, Bis JC, Sitlani CM, Bartz TM, Biggs ML, Bansal N, B?zková P, Carr SA, et al. Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing. Eur J Epidemiol. 2022  .

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022  .

Quaye E, Galecki AT, Tilton N, Whitney R, Briceño EM, Elkind MSV, Fitzpatrick AL, Gottesman RF, Griswold M, Gross AL, et al. Association of Obesity With Cognitive Decline in Black and White Americans. Neurology. 2023  ;100(2):e220-e231.

Georgakis MK, Malik R, Hasbani NR, Shakt G, Morrison AC, Tsao NL, Judy R, Mitchell BD, Xu H, Montasser ME, et al. Carriers of rare damaging  genetic variants are at lower risk of atherosclerotic disease. medRxiv. 2023  .

Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, et al. Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics. medRxiv. 2023  .

Cole KL, Boehme AK, Thacker EL, Longstreth WT, Brown BL, Gale SD, Hedges DW, Anderson JK, Elkind MSV. Hospital-Acquired Infection at Time of Stroke and Cognitive Decline: The Cardiovascular Health Study. Cerebrovasc Dis. 2023  .

Chwa WJong, Lopez OL, Longstreth WT, Dai W, Raji CA. Longitudinal Patterns of Brain Changes in a Community Sample in Relation to Aging and Cognitive Status. J Alzheimers Dis. 2023  .

Besser LM, Lovasi GS, Zambrano JJimenez, Camacho S, Dhanekula D, Michael YL, Garg P, Hirsch JA, Siscovick D, Hurvitz PM, et al. Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study. Alzheimers Dement (Amst). 2023  ;15(4):e12484.

Kalani R, Bartz TM, Psaty BM, Elkind MSV, Floyd JS, Gerszten RE, Shojaie A, Heckbert SR, Bis JC, Austin TR, et al. Plasma Proteomic Associations With Incident Ischemic Stroke in Older Adults: The Cardiovascular Health Study. Neurology. 2023  .

Lemaitre RN, Jensen PN, Wang Z, Fretts AM, Sitlani CM, Nemet I, Sotoodehnia N, Otto MC de Olive, Zhu W, Budoff M, et al. Plasma Trimethylamine--Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2023  ;12(16):e8711.

Moseholm KF, Horn JW, Fitzpatrick AL, Djoussé L, Longstreth WT, Lopez OL, Hoofnagle AN, Jensen MK, Lemaitre RN, Mukamal KJ. Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study. Front Neurol. 2024  ;15:1385623.

Moseholm KF, Cronjé HT, Koch M, Fitzpatrick AL, Lopez OL, Otto MC de Olive, Longstreth WT, Hoofnagle AN, Mukamal KJ, Lemaitre RN, et al. Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study. Alzheimers Dement (Amst). 2024  ;16(3):e12623.

Sargurupremraj M, Soumaré A, Bis JC, Surakka I, Jürgenson T, Joly P, Knol MJ, Wang R, Yang Q, Satizabal CL, et al. Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia. JAMA Netw Open. 2024  ;7(5):e2412824.

Gomez GT, Shi L, Fohner AE, Chen J, Yang Y, Fornage M, Duggan MR, Peng Z, Daya GN, Tin A, et al. Plasma proteome-wide analysis of cerebral small vessel disease identifies novel biomarkers and disease pathways. medRxiv. 2024  .

Moseholm KF, Jensen MK, B?zková P, Aroner SA, Fitzpatrick AL, Longstreth WT, Lopez O, Siscovick DS, Kizer JR, Ix JH, et al. Circulating non-esterified fatty acids, risk of dementia and cognitive decline: The cardiovascular health study and multi-ethnic study of atherosclerosis. Neurobiol Aging. 2025  ;148:71-79.

Georgakis MK, Malik R, Bounkari OEl, Hasbani NR, Li J, Huffman JE, Shakt G, Tack RWP, Kimball TN, Asare Y, et al. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome Med. 2025  ;17(1):27.