%0 Journal Article %J J Am Geriatr Soc %D 2008 %T Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults. %A Kaplan, Robert C %A McGinn, Aileen P %A Pollak, Michael N %A Kuller, Lewis %A Strickler, Howard D %A Rohan, Thomas E %A Xue, XiaoNan %A Kritchevsky, Stephen B %A Newman, Anne B %A Psaty, Bruce M %K Activities of Daily Living %K Aged %K Aged, 80 and over %K Biomarkers %K Cardiovascular Diseases %K Enzyme-Linked Immunosorbent Assay %K Fasting %K Female %K Follow-Up Studies %K Hand Strength %K Humans %K Incidence %K Insulin-Like Growth Factor Binding Protein 1 %K Insulin-Like Growth Factor Binding Protein 3 %K Insulin-Like Growth Factor I %K Male %K Middle Aged %K Prognosis %K Prospective Studies %K Risk Factors %K Survival Rate %K United States %K Walking %X

OBJECTIVES: To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults.

DESIGN: Cohort study.

SETTING/PARTICIPANTS: One thousand one hundred twenty-two individuals aged 65 and older without prior cardiovascular disease events participating in the Cardiovascular Health Study.

MEASUREMENTS: Baseline fasting plasma levels of IGF-1, IGFBP-1, and IGFBP-3 (defined as tertiles, T1-T3) were examined in relationship to handgrip strength, time to walk 15 feet, development of new difficulties with activities of daily living (ADLs), and mortality.

RESULTS: Higher IGFBP-1 predicted worse handgrip strength (P-trend(T1-T3)<.01) and slower walking speed (P-trend(T1-T3)=.03), lower IGF-1 had a borderline significant association with worse handgrip strength (P-trend(T1-T3)=.06), and better grip strength was observed in the middle IGFBP-3 tertile than in the low or high tertiles (P=.03). Adjusted for age, sex, and race, high IGFBP-1 predicted greater mortality (P-trend(T1-T3)<.001, hazard ratio (HR)(T3vsT1)=1.48, 95% confidence interval (CI)=1.15-1.90); this association was borderline significant after additional confounder adjustment (P-trend(T1-T3)=.05, HR(T3vsT1)=1.35, 95% CI=0.98-1.87). High IGFBP-1 was associated with greater risk of incident ADL difficulties after adjustment for age, sex, race, and other confounders (P-trend(T1-T3)=.04, HR(T3vsT1)=1.40, CI=1.01-1.94). Neither IGF-1 nor IGFBP-3 level predicted mortality or incident ADL difficulties.

CONCLUSION: In adults aged 65 and older, high IGFBP-1 levels were associated with greater risk of mortality and poorer functional ability, whereas IGF-1 and IGFBP-3 had little association with these outcomes.

%B J Am Geriatr Soc %V 56 %P 652-60 %8 2008 Apr %G eng %N 4 %1 https://www.ncbi.nlm.nih.gov/pubmed/18312313?dopt=Abstract %R 10.1111/j.1532-5415.2007.01637.x