%0 Journal Article %J Circulation %D 2000 %T Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study. %A Siscovick, D S %A Schwartz, S M %A Corey, L %A Grayston, J T %A Ashley, R %A Wang, S P %A Psaty, B M %A Tracy, R P %A Kuller, L H %A Kronmal, R A %K Adult %K Age Factors %K Aged %K Antibodies, Bacterial %K Antibodies, Viral %K Case-Control Studies %K Chlamydophila pneumoniae %K Coronary Disease %K Cytomegalovirus %K Female %K Herpesvirus 1, Human %K HIV Antibodies %K Humans %K Immunoglobulin G %K Male %K Myocardial Infarction %K Risk Factors %X

BACKGROUND: Whether serological evidence of prior infection with Chlamydia pneumoniae, herpes simplex virus type 1 (HSV-1), and cytomegalovirus (CMV) is associated with myocardial infarction (MI) and coronary heart disease (CHD) death remains a source of controversy.

METHODS AND RESULTS: We conducted a nested case-control study among participants in the Cardiovascular Health Study, a cohort study of persons aged >/=65 years. Cases experienced an incident MI and CHD death (n=213). Control subjects were matched to cases by age, sex, clinic, year of enrollment, and month of blood draw (n=405). Serum was analyzed for IgG antibodies to C pneumoniae, HSV-1, and CMV. After adjustment for other risk factors, the risk of MI and CHD death was associated with the presence of IgG antibodies to HSV-1 (odds ratio [OR] 2.0, 95% CI 1.1 to 3.6) but was not associated with the presence of IgG antibodies to either C pneumoniae (OR 1.1, 95% CI 0.7 to 1.8) or CMV (OR 1.2, 95% CI 0.7 to 1.9). Although there was little association with low to moderate C pneumoniae antibody titers (

CONCLUSIONS: Among older adults, the presence of IgG antibodies to HSV-1 was associated with a 2-fold increase in the risk of incident MI and CHD death. For C pneumoniae, only high-titer IgG antibodies were associated with an increased risk of MI and CHD death. The presence of IgG antibodies to CMV was not associated with risk among the elderly.

%B Circulation %V 102 %P 2335-40 %8 2000 Nov 07 %G eng %N 19 %1 https://www.ncbi.nlm.nih.gov/pubmed/11067785?dopt=Abstract %R 10.1161/01.cir.102.19.2335