%0 Journal Article %J J Thromb Haemost %D 2006 %T Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults. %A Jenny, N S %A Arnold, A M %A Kuller, L H %A Sharrett, A R %A Fried, L P %A Psaty, B M %A Tracy, R P %K Aged %K Aged, 80 and over %K Angina Pectoris %K Biomarkers %K Cardiovascular Diseases %K Female %K Humans %K Incidence %K Intercellular Adhesion Molecule-1 %K Male %K Mortality %K Myocardial Infarction %K Regression Analysis %K Risk Factors %K Sex Factors %K Solubility %K Stroke %X

BACKGROUND: Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.

OBJECTIVES: We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.

METHODS: Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.

RESULTS: sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.

CONCLUSIONS: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.

%B J Thromb Haemost %V 4 %P 107-13 %8 2006 Jan %G eng %N 1 %1 https://www.ncbi.nlm.nih.gov/pubmed/16409459?dopt=Abstract %R 10.1111/j.1538-7836.2005.01678.x