%0 Journal Article %J J Am Geriatr Soc %D 2011 %T Serum 25-hydroxyvitamin D and physical function in older adults: the Cardiovascular Health Study All Stars. %A Houston, Denise K %A Tooze, Janet A %A Davis, Cralen C %A Chaves, Paulo H M %A Hirsch, Calvin H %A Robbins, John A %A Arnold, Alice M %A Newman, Anne B %A Kritchevsky, Stephen B %K Activities of Daily Living %K Aged %K Aged, 80 and over %K Female %K Follow-Up Studies %K Geriatric Assessment %K Health Surveys %K Humans %K Male %K Mobility Limitation %K Muscle Strength %K Physical Fitness %K Proportional Hazards Models %K Reference Values %K United States %K Vitamin D %K Vitamin D Deficiency %X

OBJECTIVES: To examine the association between 25-hydroxyvitamin D (25(OH)D) and physical function in adults of advanced age.

DESIGN: Cross-sectional and longitudinal analysis of physical function over 3 years of follow-up in the Cardiovascular Health Study All Stars.

SETTING: Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Allegheny County, Pennsylvania.

PARTICIPANTS: Community-dwelling adults aged 77 to 100 (N = 988).

MEASUREMENTS: Serum 25-hydroxyvitamin D 25(OH)D), Short Physical Performance Battery (SPPB), and grip and knee extensor strength assessed at baseline. Mobility disability (difficulty walking half a mile or up 10 steps) and activities of daily living (ADLs) disability were assessed at baseline and every 6 months over 3 years of follow-up.

RESULTS: Almost one-third (30.8%) of participants were deficient in 25(OH)D (<20 ng/mL). SPPB scores were lower in those with deficient 25(OH)D (mean (standard error) 6.53 (0.24)) than in those with sufficient 25(OH)D (≥30 ng/mL) (7.15 (0.25)) after adjusting for sociodemographic characteristics, season, health behaviors, and chronic conditions (P = .006). Grip strength adjusted for body size was also lower in those with deficient 25(OH)D than in those with sufficient 25(OH)D (24.7 (0.6) kg vs 26.0 (0.6) kg, P = .02). Participants with deficient 25(OH)D were more likely to have prevalent mobility (OR = 1.44, 95% confidence interval (CI)) = 0.96-2.14) and ADL disability (OR = 1.51, 95% CI = 1.01-2.25) at baseline than those with sufficient 25(OH)D. Furthermore, participants with deficient 25(OH)D were at greater risk of incident mobility disability over 3 years of follow-up (hazard ratio = 1.56, 95% CI = 1.06-2.30).

CONCLUSION: Vitamin D deficiency was common and was associated with poorer physical performance, lower muscle strength, and prevalent mobility and ADL disability in community-dwelling older adults. Moreover, vitamin D deficiency predicted incident mobility disability.

%B J Am Geriatr Soc %V 59 %P 1793-801 %8 2011 Oct %G eng %N 10 %1 http://www.ncbi.nlm.nih.gov/pubmed/22091492?dopt=Abstract %R 10.1111/j.1532-5415.2011.03601.x