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Journal Article

Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, Otto MC de Olive, DiDonato JA, Lee Y, Psaty BM, et al. Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults. JAMA Netw Open. 2022 ;5(5):e2213242.

Lemaitre RN, Jensen PN, Wang Z, Fretts AM, McKnight B, Nemet I, Biggs ML, Sotoodehnia N, Otto MC de Olive, Psaty BM, et al. Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study. JAMA Netw Open. 2021 ;4(8):e2122844.

Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PIW, Mueller M, Lubitz SA, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010 ;42(3):240-4.

Wang M, Wang Z, Lee Y, Lai HTM, Otto MC de Olive, Lemaitre RN, Fretts A, Sotoodehnia N, Budoff M, DiDonato JA, et al. Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2022 ;42(9):e273-e288.

Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, et al. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. Eur Heart J. 2012 ;33(2):238-51.

Do R, Stitziel NO, Won H-H, Jørgensen ABerg, Duga S, Merlini PAngelica, Kiezun A, Farrall M, Goel A, Zuk O, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 ;518(7537):102-6.

Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013 ;22(16):3381-93.

Wang M, Tang WHWilson, Li XS, Otto MC de Olive, Lee Y, Lemaitre RN, Fretts A, Nemet I, Sotoodehnia N, Sitlani CM, et al. The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline. J Am Soc Nephrol. 2024 .

Otto MC de Olive, Li XS, Wang Z, Siscovick D, Newman AB, Lai HTsz Mung, Nemet I, Lee Y, Wang M, Fretts A, et al. Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study. J Alzheimers Dis. 2022 .

Lee Y, Nemet I, Wang Z, Lai HTM, Otto MC de Olive, Lemaitre RN, Fretts AM, Sotoodehnia N, Budoff M, DiDonato JA, et al. Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults. J Am Heart Assoc. 2021 :e020646.

Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 2011 ;480(7376):201-8.

Lemaitre RN, Jensen PN, Wang Z, Fretts AM, Sitlani CM, Nemet I, Sotoodehnia N, Otto MC de Olive, Zhu W, Budoff M, et al. Plasma Trimethylamine--Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2023 ;12(16):e8711.

Elam RE, Bůzková P, Barzilay JI, Wang Z, Nemet I, Budoff MJ, Cauley JA, Fink HA, Lee Y, Robbins JA, et al. Trimethylamine N-oxide and hip fracture and bone mineral density in older adults: The cardiovascular health study. Bone. 2022 ;161:116431.

Tang WHWilson, Katz R, Brennan M-L, Aviles RJ, Tracy RP, Psaty BM, Hazen SL. Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure. Am J Cardiol. 2009 ;103(9):1269-74.