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Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
Wednesday,2021-04-21 16:45 America/Los_Angeles — ecterry
| Title | Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Natarajan, P, Pampana, A, Graham, SE, Ruotsalainen, SE, Perry, JA, de Vries, PS, Broome, JG, Pirruccello, JP, Honigberg, MC, Aragam, K, Wolford, B, Brody, JA, Antonacci-Fulton, L, Arden, M, Aslibekyan, S, Assimes, TL, Ballantyne, CM, Bielak, LF, Bis, JC, Cade, BE, Do, R, Doddapaneni, H, Emery, LS, Hung, Y-J, Irvin, MR, Khan, AT, Lange, L, Lee, J, Lemaitre, RN, Martin, LW, Metcalf, G, Montasser, ME, Moon, J-Y, Muzny, D, O'Connell, JR, Palmer, ND, Peralta, JM, Peyser, PA, Stilp, AM, Tsai, M, Wang, FFei, Weeks, DE, Yanek, LR, Wilson, JG, Abecasis, G, Arnett, DK, Becker, LC, Blangero, J, Boerwinkle, E, Bowden, DW, Chang, Y-C, Chen, Y-derI, Choi, WJung, Correa, A, Curran, JE, Daly, MJ, Dutcher, SK, Ellinor, PT, Fornage, M, Freedman, BI, Gabriel, S, Germer, S, Gibbs, RA, He, J, Hveem, K, Jarvik, GP, Kaplan, RC, Kardia, SLR, Kenny, E, Kim, RW, Kooperberg, C, Laurie, CC, Lee, S, Lloyd-Jones, DM, Loos, RJF, Lubitz, SA, Mathias, RA, Martinez, KAViaud, McGarvey, ST, Mitchell, BD, Nickerson, DA, North, KE, Palotie, A, Park, CJoo, Psaty, BM, Rao, DC, Redline, S, Reiner, AP, Seo, D, Seo, J-S, Smith, AV, Tracy, RP, Vasan, RS, Kathiresan, S, Cupples, AL, Rotter, JI, Morrison, AC, Rich, SS, Ripatti, S, Willer, C, Peloso, GM |
| Corporate/Institutional Authors | NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, FinnGen |
| Journal | Nat Commun |
| Volume | 12 |
| Issue | 1 |
| Pagination | 2182 |
| Date Published | 2021 04 12 |
| ISSN | 2041-1723 |
| Abstract | <p>Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.</p> |
| DOI | 10.1038/s41467-021-22339-1 |
| Alternate Journal | Nat Commun |
| PubMed ID | 33846329 |
| Grant List | R01 HL139731 / HL / NHLBI NIH HHS / United States R35 HL135818 / HL / NHLBI NIH HHS / United States R01 HL148050 / HL / NHLBI NIH HHS / United States K01 HL125751 / HL / NHLBI NIH HHS / United States R01 HL142711 / HL / NHLBI NIH HHS / United States R03 HL141439 / HL / NHLBI NIH HHS / United States K01 HL135405 / HL / NHLBI NIH HHS / United States K08 HL140203 / HL / NHLBI NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States R01 HL148565 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States |
ePub date:
21/04