The Cardiovascular Health Study

Sponsored by the National Heart, Lung and Blood Institute

The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging (MRI). At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status. The main outcomes are coronary heart disease (CHD), angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication, and mortality. Participants continue to be contacted by phone every 6 months. 

To date, more than 1900 papers from CHS have been published and more than 400 ancillary studies are ongoing or complete.

CHS listing at



CHS solicits applications proposing research projects that involve assays of stored CHS biospecimens. Funding is available for a minimum of $50,000 and maximum of $150,000 for laboratory assays.



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