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The relationship between exercise and risk of venous thrombosis in elderly people.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | The relationship between exercise and risk of venous thrombosis in elderly people. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | van Stralen, KJ, Doggen, CJM, Lumley, T, Cushman, M, Folsom, AR, Psaty, BM, Siscovick, D, Rosendaal, FR, Heckbert, SR |
| Journal | J Am Geriatr Soc |
| Volume | 56 |
| Issue | 3 |
| Pagination | 517-22 |
| Date Published | 2008 Mar |
| ISSN | 1532-5415 |
| Keywords | Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Energy Metabolism, Exercise, Female, Humans, Male, Prevalence, Risk Factors, United States, Venous Thrombosis |
| Abstract | <p><b>OBJECTIVES: </b>To study whether exercise is associated with the risk of venous thrombosis in elderly people.</p><p><b>DESIGN: </b>Observational study with a median follow-up of 11.6 years.</p><p><b>SETTING: </b>The Cardiovascular Health Study in four U.S. communities.</p><p><b>PARTICIPANTS: </b>People aged 65 and older without prior venous thrombosis (deep venous thrombosis or pulmonary embolism).</p><p><b>MEASUREMENTS: </b>Self-reported exercise was measured two or three times during follow-up and was defined as expending more than 500 kcal/wk on exercise, including walking for exercise. Venous thrombosis cases were verified using medical record review.</p><p><b>RESULTS: </b>Of 5,534 participants, 171 developed a first venous thrombosis. Self-reported exercise at baseline was not related to the risk of venous thrombosis after adjustment for sex, age, race, self-reported health, and body mass index (adjusted hazard ratio (HR(adj))=1.16, 95% confidence interval (CI)=0.84-1.61), although with exercise modeled as a time-varying exposure, overall results were in the direction of greater risk of venous thrombosis (HR(adj)=1.38, 95% CI=0.99-1.91). For mild-intensity exercise, such as walking, there was a nonsignificant finding in the direction of benefit (HR(adj)=0.75, 95% CI=0.49-1.16), but strenuous exercise, such as jogging, was associated with greater risk of venous thrombosis (HR(adj)=1.75, 95% CI=1.08-2.83) than no exercise at all.</p><p><b>CONCLUSION: </b>In elderly people, strenuous exercise was associated with a higher risk of venous thrombosis than no exercise at all. Future studies are needed to explain this unexpected higher risk.</p> |
| DOI | 10.1111/j.1532-5415.2007.01588.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 18179500 |
| PubMed Central ID | PMC: N/A |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01-HL-59367 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States |