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Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Irie, F, Fitzpatrick, AL, Lopez, OL, Kuller, LH, Peila, R, Newman, AB, Launer, LJ |
| Journal | Arch Neurol |
| Volume | 65 |
| Issue | 1 |
| Pagination | 89-93 |
| Date Published | 2008 Jan |
| ISSN | 0003-9942 |
| Keywords | African Americans, Age Factors, Aged, Alzheimer Disease, Apolipoprotein E4, Cognition, Cohort Studies, Confidence Intervals, Dementia, Vascular, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genotype, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Proportional Hazards Models, Prospective Studies, Risk Factors, Sex Factors |
| Abstract | <p><b>BACKGROUND: </b>Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes.</p><p><b>OBJECTIVE: </b>To examine the joint effect of type 2 diabetes and APOE epsilon4 on the risk of AD, AD with vascular dementia (mixed AD), and vascular dementia without AD.</p><p><b>DESIGN: </b>The Cardiovascular Health Study (CHS) Cognition Study (1992-2000) is a prospective study designed to identify all existing and new cases of dementia among study participants. Diagnoses were made according to international criteria for dementia and subtypes. There were 2547 dementia-free participants in the CHS Cognition Study cohort with complete information on APOE epsilon4 and type 2 diabetes status; among these, 411 new cases of dementia developed. Risk of dementia was estimated with a Cox proportional hazard model adjusted for age and other demographic and cardiovascular risk factors.</p><p><b>RESULTS: </b>Compared with those who had neither type 2 diabetes nor APOE epsilon4, those with both factors had a significantly higher risk of AD (hazard ratio, 4.58; 95% confidence interval, 2.18-9.65) and mixed AD (hazard ratio, 3.89; 95% confidence interval, 1.46-10.40).</p><p><b>CONCLUSION: </b>These data suggest that having both diabetes and APOE epsilon4 increases the risk of dementia, especially for AD and mixed AD.</p> |
| DOI | 10.1001/archneurol.2007.29 |
| Alternate Journal | Arch Neurol |
| PubMed ID | 18195144 |
| PubMed Central ID | PMC: N/A |
| Grant List | 5R01 AG15928-02 / AG / NIA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States / / Intramural NIH HHS / United States |