You are here
Cardiovascular risk factors and incident acute renal failure in older adults: the cardiovascular health study.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Cardiovascular risk factors and incident acute renal failure in older adults: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Mittalhenkle, A, Stehman-Breen, CO, Shlipak, MG, Fried, LF, Katz, R, Young, BA, Seliger, S, Gillen, D, Newman, AB, Psaty, BM, Siscovick, D |
| Journal | Clin J Am Soc Nephrol |
| Volume | 3 |
| Issue | 2 |
| Pagination | 450-6 |
| Date Published | 2008 Mar |
| ISSN | 1555-905X |
| Keywords | Acute Kidney Injury, Aged, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Risk Factors |
| Abstract | <p><b>BACKGROUND AND OBJECTIVES: </b>Although the elderly are at increased risk for acute renal failure, few prospective studies have identified risk factors for acute renal failure in the elderly.</p><p><b>DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: </b>The associations of cardiovascular disease risk factors, subclinical cardiovascular disease, and clinical coronary heart disease with the risk for development of acute renal failure were examined in older adults in the Cardiovascular Health Study, a prospective cohort study of community-dwelling older adults. Incident hospitalized cases of acute renal failure were identified through hospital discharge International Classification of Diseases, Ninth Revision codes and confirmed through physician diagnoses of acute renal failure in discharge summaries.</p><p><b>RESULTS: </b>Acute renal failure developed in 225 (3.9%) of the 5731 patients during a median follow-up period of 10.2 yr. In multivariate analyses, diabetes, current smoking, hypertension, C-reactive protein, and fibrinogen were associated with acute renal failure. Prevalent coronary heart disease was associated with incident acute renal failure, and among patients without prevalent coronary heart disease, subclinical vascular disease measures were also associated with acute renal failure: Low ankle-arm index (< or =0.9), common carotid intima-media thickness, and internal carotid intima-media thickness.</p><p><b>CONCLUSIONS: </b>In this large, population-based, prospective cohort study, cardiovascular risk factors and both subclinical and clinical vascular disease were associated with incident acute renal failure in the elderly.</p> |
| DOI | 10.2215/CJN.02610607 |
| Alternate Journal | Clin J Am Soc Nephrol |
| PubMed ID | 18256380 |
| PubMed Central ID | PMC2390946 |
| Grant List | N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States T32 DK007721 / DK / NIDDK NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States R01 HL073208 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States DK07721 / DK / NIDDK NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States |