You are here

Left ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study.

TitleLeft ventricular morphology and systolic function in sleep-disordered breathing: the Sleep Heart Health Study.
Publication TypeJournal Article
Year of Publication2008
AuthorsChami, HA, Devereux, RB, Gottdiener, JS, Mehra, R, Roman, MJ, Benjamin, EJ, Gottlieb, DJ
JournalCirculation
Volume117
Issue20
Pagination2599-607
Date Published2008 May 20
ISSN1524-4539
KeywordsAged, Echocardiography, Female, Humans, Hypertrophy, Left Ventricular, Hypoxia, Male, Middle Aged, Odds Ratio, Sleep Apnea Syndromes, Systole, Ventricular Dysfunction, Left
Abstract<p><b>BACKGROUND: </b>Whether sleep-disordered breathing (SDB) is a risk factor for left ventricular (LV) hypertrophy and dysfunction is controversial. We assessed the relation of SDB to LV morphology and systolic function in a community-based sample of middle-aged and older adults.</p><p><b>METHODS AND RESULTS: </b>The present study was a cross-sectional observational study of 2058 Sleep Heart Health Study participants (mean age 65+/-12 years; 58% women; 44% ethnic minorities) who had technically adequate echocardiograms. A polysomnographically derived apnea-hypopnea index (AHI) and hypoxemia index (percent of sleep time with oxyhemoglobin saturation < 90%) were used to quantify SDB severity. LV mass index was significantly associated with both AHI and hypoxemia index after adjustment for age, sex, ethnicity, study site, body mass index, current and prior smoking, alcohol consumption, systolic blood pressure, antihypertensive medication use, diabetes mellitus, and prevalent myocardial infarction. Adjusted LV mass index was 41.3 (SD 9.90) g/m(2.7) in participants with AHI < 5 (n=957) and 44.1 (SD 9.90) g/m(2.7) in participants with AHI > or = 30 (n=84) events per hour. Compared with participants with AHI < 5, those with AHI > or = 30 had an adjusted odds ratio of 1.78 (95% confidence interval 1.14 to 2.79) for LV hypertrophy. A higher AHI and higher hypoxemia index were also associated with larger LV diastolic dimension and lower LV ejection fraction, with a trend toward lower LV fractional shortening. LV wall thickness was significantly associated with the hypoxemia index but not with AHI. Left atrial diameter was not associated with either SDB measure.</p><p><b>CONCLUSIONS: </b>In a community-based cohort, SDB is associated with echocardiographic evidence of increased LV mass and reduced LV systolic function.</p>
DOI10.1161/CIRCULATIONAHA.107.717892
Alternate JournalCirculation
PubMed ID18458174
PubMed Central IDPMC2813728
Grant ListN01-HC-25195 / HC / NHLBI NIH HHS / United States
HL-65521 / HL / NHLBI NIH HHS / United States
U01 HL053934-14 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
U01 HL041642 / HL / NHLBI NIH HHS / United States
U01HL53937 / HL / NHLBI NIH HHS / United States
U01 HL053931-10 / HL / NHLBI NIH HHS / United States
U01 HL053916 / HL / NHLBI NIH HHS / United States
U01 HL041642-19 / HL / NHLBI NIH HHS / United States
U01 HL063463-09 / HL / NHLBI NIH HHS / United States
U01 HL041654 / HL / NHLBI NIH HHS / United States
U01 HL041654-20 / HL / NHLBI NIH HHS / United States
N01-HC85086 / HC / NHLBI NIH HHS / United States
HL-41642 / HL / NHLBI NIH HHS / United States
R01 HL075078 / HL / NHLBI NIH HHS / United States
N01-HC85079 / HC / NHLBI NIH HHS / United States
U01 HL-080295 / HL / NHLBI NIH HHS / United States
HL-30605 / HL / NHLBI NIH HHS / United States
U01 HL053941-09 / HL / NHLBI NIH HHS / United States
U01HL64360 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
U01 HL063463 / HL / NHLBI NIH HHS / United States
N01-HC85083 / HC / NHLBI NIH HHS / United States
U01 HL063429-09 / HL / NHLBI NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
U01 HL053916-14 / HL / NHLBI NIH HHS / United States
U01 HL065521-08 / HL / NHLBI NIH HHS / United States
U01HL53938 / HL / NHLBI NIH HHS / United States
U01 HL080295-05 / HL / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
P01 HL047540 / HL / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
U01 HL064360-09 / HL / NHLBI NIH HHS / United States
R01 NS017950-28 / NS / NINDS NIH HHS / United States
R01 HL080124-05 / HL / NHLBI NIH HHS / United States
U01 HL053938 / HL / NHLBI NIH HHS / United States
U01 HL041652 / HL / NHLBI NIH HHS / United States
HL080124 / HL / NHLBI NIH HHS / United States
U01 HL053941-14 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
U01HL53934 / HL / NHLBI NIH HHS / United States
U01 HL064360 / HL / NHLBI NIH HHS / United States
U01 HL053940-05 / HL / NHLBI NIH HHS / United States
N01-HC85082 / HC / NHLBI NIH HHS / United States
2U01-HL53941 / HL / NHLBI NIH HHS / United States
HL-41654 / HL / NHLBI NIH HHS / United States
6R01-NS-17950 / NS / NINDS NIH HHS / United States
U01 HL041652-20 / HL / NHLBI NIH HHS / United States
U01 HL053941 / HL / NHLBI NIH HHS / United States
U01 HL053937-14 / HL / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
U01HL63429 / HL / NHLBI NIH HHS / United States
U01HL53931 / HL / NHLBI NIH HHS / United States
N01-HC85081 / HC / NHLBI NIH HHS / United States
U01HL53941 / HL / NHLBI NIH HHS / United States
U01 HL053934 / HL / NHLBI NIH HHS / United States
U01HL53916 / HL / NHLBI NIH HHS / United States
U01 HL063429 / HL / NHLBI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
N01-HC85085 / HC / NHLBI NIH HHS / United States
N01-HC85080 / HC / NHLBI NIH HHS / United States
HL-41652 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
U01 HL065521 / HL / NHLBI NIH HHS / United States
HL-47540 / HL / NHLBI NIH HHS / United States
U01 HL053938-14 / HL / NHLBI NIH HHS / United States
N01-HC85084 / HC / NHLBI NIH HHS / United States
R01 HL080124 / HL / NHLBI NIH HHS / United States
U01 HL053937 / HL / NHLBI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
U01HL53940 / HL / NHLBI NIH HHS / United States
U01HL63463 / HL / NHLBI NIH HHS / United States
N01-HC-5222 / HC / NHLBI NIH HHS / United States
U01 HL053931 / HL / NHLBI NIH HHS / United States