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Heart rate variability and its changes over 5 years in older adults.
Tuesday,2012-11-06 12:10 America/Los_Angeles — eenright
| Title | Heart rate variability and its changes over 5 years in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Stein, PK, Barzilay, JI, Chaves, PHM, Domitrovich, PP, Gottdiener, JS |
| Journal | Age Ageing |
| Volume | 38 |
| Issue | 2 |
| Pagination | 212-8 |
| Date Published | 2009 Mar |
| ISSN | 1468-2834 |
| Keywords | Age Distribution, Aged, Aging, Atrial Premature Complexes, Autonomic Nervous System, Cardiovascular Diseases, Cross-Sectional Studies, Electrocardiography, Ambulatory, Female, Heart Rate, Humans, Hypertension, Male, Nonlinear Dynamics, Prevalence, Prospective Studies, Risk Factors, Ventricular Premature Complexes |
| Abstract | <p><b>PURPOSE: </b>to characterise the association between age, ageing and heart rate variability (HRV) in older individuals, 585 adults age >65 years with two 24-h Holter recordings in the Cardiovascular Health Study were studied.</p><p><b>METHODS: </b>heart rate (HR), ventricular premature contractions (VPCs), atrial premature contractions (APCs), frequency-domain, ratio-based and non-linear HRV and heart rate turbulence (HRT) were examined cross-sectionally by 5-year age groups and prospectively over 5 years. Analyses adjusted for gender, lower versus elevated cardiovascular (CV) risk and for the change in CV risk.</p><p><b>RESULTS: </b>HR declined, and VPCs and APCs increased per 5-year increase in age. Frequency-domain HRV decreased more at 65-69, less at 70-74 and minimally at > or =75 years, independent of CVD risk or change in CVD risk. Ratio and non-linear HRV continued to decline to > or =75 years old. Ratio HRV and HRT slope were more strongly related to CVD risk than frequency-domain HRV.</p><p><b>CONCLUSIONS: </b>cardiac autonomic function, assessed by frequency-domain HRV, declines most at 65-70 and levels off at age >75. The decline is independent of CVD risk or change in CVD risk. Ratio-based and non-linear HRV and HRT slope continued to change with increasing age and were more closely related to CVD risk than frequency-domain HRV.</p> |
| DOI | 10.1093/ageing/afn292 |
| Alternate Journal | Age Ageing |
| PubMed ID | 19147739 |
| PubMed Central ID | PMC2724889 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01 HL062181 / HL / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R0-1 HL62181 / HL / NHLBI NIH HHS / United States |