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Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:10 America/Los_Angeles — eenright
| Title | Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Sun, C, Wang, JJ, Islam, FM, Heckbert, SR, Klein, R, Siscovick, DS, Klein, BEK, Wong, TY |
| Journal | J Hum Hypertens |
| Volume | 23 |
| Issue | 9 |
| Pagination | 578-84 |
| Date Published | 2009 Sep |
| ISSN | 1476-5527 |
| Keywords | African Americans, Aged, Aged, 80 and over, Arterioles, Calmodulin-Binding Proteins, European Continental Ancestry Group, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Longitudinal Studies, Polymorphism, Single Nucleotide, Receptors, Adrenergic, beta-2, Retinal Vessels |
| Abstract | <p>We examined the associations of single nucleotide polymorphisms (SNPs) in three candidate hypertension genes, alpha-adducin (ADD1/G460W), beta2-adrenergic receptor (ADRB2/Arg16Gly and Gln27Glu) and G-protein beta3 subunit (GNB3/C825T), with retinal arteriolar calibre (an intermediate marker of chronic hypertension) and venular calibre. Data in 1842 participants (1554 whites and 288 African Americans) aged 69-96 years from the Cardiovascular Health Study with genotype and retinal vascular calibre data were included. A computer-assisted method was used to measure retinal vascular calibre. We analysed four SNPs and multilocus interaction for three genes. All SNPs were in Hardy-Weinberg equilibrium in whites and African Americans. The study had sufficient power to detect 0.5% of the total variance of retinal vascular calibre contributed by each SNP in the total population, except for the GNB3 gene variant. No significant associations between these SNPs in the genes studied and mean retinal arteriolar and venular calibre were found in single-gene or multilocus analysis (for example, age-, gender-, race-adjusted mean retinal arteriolar calibre was similar between participants who were ADD1/460W homozygotes and ADD1/G allele carriers, 166.2 vs 167.7 microm). In conclusion, this study found no evidence of an association of SNPs in candidate hypertension genes studied here with retinal vascular calibre.</p> |
| DOI | 10.1038/jhh.2008.168 |
| Alternate Journal | J Hum Hypertens |
| PubMed ID | 19148102 |
| PubMed Central ID | PMC2888043 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R21-HL077166 / HL / NHLBI NIH HHS / United States AG015366 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R21 HL077166-01 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States R21 HL077166 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |