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Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Baker, ML, Wang, JJin, Rogers, S, Klein, R, Kuller, LH, Larsen, EK, Wong, TYin |
| Journal | Arch Ophthalmol |
| Volume | 127 |
| Issue | 5 |
| Pagination | 667-73 |
| Date Published | 2009 May |
| ISSN | 1538-3601 |
| Keywords | Aged, Aged, 80 and over, Cardiovascular Diseases, Cognition Disorders, Dementia, Female, Humans, Intelligence Tests, Macular Degeneration, Male, Neuropsychological Tests, Odds Ratio, Prospective Studies, Risk Factors, United States |
| Abstract | <p><b>OBJECTIVE: </b>To describe the association of cognitive function and dementia with early age-related macular degeneration (AMD) in older individuals.</p><p><b>METHODS: </b>This population-based study included 2,088 persons aged 69 to 97 years who participated in the Cardiovascular Health Study. The AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST) and the Modified Mini-Mental State Examination. Participants were also evaluated for dementia using detailed neuropsychological testing.</p><p><b>RESULTS: </b>After controlling for age, sex, race, and study center, persons with low DSST scores (lowest quartile of scores, < or =30) were more likely to have early AMD (odds ratio, 1.38; 95% confidence interval, 1.03-1.85) than were persons with higher DSST scores. In analyses further controlling for education, systolic blood pressure, total cholesterol level, diabetes mellitus, smoking status, and apolipoprotein E genotype, this association was stronger (odds ratio, 2.00; 95% confidence interval, 1.29-3.10). There was no association of low Modified Mini-Mental State Examination scores, dementia, or Alzheimer disease with early AMD.</p><p><b>CONCLUSIONS: </b>In this older population, cognitive impairment may share common age-related pathogenesis and risk factors with early AMD.</p> |
| DOI | 10.1001/archophthalmol.2009.30 |
| Alternate Journal | Arch. Ophthalmol. |
| PubMed ID | 19433718 |
| PubMed Central ID | PMC3001290 |
| Grant List | N01 HC085086 / HC / NHLBI NIH HHS / United States N01 HC085083 / HC / WHI NIH HHS / United States N01 HC085081 / HC / NHLBI NIH HHS / United States U01 HL080295-04 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC085083 / HC / NHLBI NIH HHS / United States R21-HL077166 / HL / NHLBI NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01 HC055222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01 HC085079 / HC / WHI NIH HHS / United States N01 HC085081 / HC / WHI NIH HHS / United States N01 HC045133 / HC / WHI NIH HHS / United States N01 HC085084 / HC / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States R21 HL077166 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R21 HL077166-02 / HL / NHLBI NIH HHS / United States |