You are here
Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Endeshaw, YW, Unruh, ML, Kutner, M, Newman, AB, Bliwise, DL |
| Journal | Am J Epidemiol |
| Volume | 170 |
| Issue | 2 |
| Pagination | 193-202 |
| Date Published | 2009 Jul 15 |
| ISSN | 1476-6256 |
| Keywords | Activities of Daily Living, Aged, Cardiovascular Diseases, Cardiovascular System, Cohort Studies, Confidence Intervals, Exercise Tolerance, Female, Frail Elderly, Hand Strength, Humans, Logistic Models, Male, Mobility Limitation, Models, Statistical, Motor Activity, Muscle Strength, Odds Ratio, Polysomnography, Psychometrics, Risk Factors, Sleep Apnea, Obstructive, Weight Loss |
| Abstract | <p>Sleep-disordered breathing (SDB) is associated with pathophysiology that may influence the development and progression of frailty. Using data collected in 1995-1996, the authors explored the relation between SDB and components of frailty among 1,042 participants of the Cardiovascular Health Study. Diagnosis of SDB was based on the results of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per hour of sleep. Slow walking speed, low grip strength, exhaustion, low physical activity, and unexplained weight loss were referred to as frailty indicator variables. There were 584 (56%) female and 458 (44%) male participants, and the mean age was 77 (standard deviation, 4) years. There was independent association between severe SDB and 1 or more frailty indicator variables (adjusted odds ratio = 4.85, 95% confidence interval: 1.40, 16.78), slow walking speed (adjusted odds ratio = 2.67, 95% confidence interval: 1.04, 6.84), and low grip strength (adjusted odds ratio = 3.29, 95% confidence interval: 1.36, 7.96) among female study participants. The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty.</p> |
| DOI | 10.1093/aje/kwp108 |
| Alternate Journal | Am. J. Epidemiol. |
| PubMed ID | 19465743 |
| PubMed Central ID | PMC2727272 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States K23 AG025963 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States UL1 TR000454 / TR / NCATS NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States K23 AG 025963 / AG / NIA NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |