You are here
Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Winkelman, JW, Redline, S, Baldwin, CM, Resnick, HE, Newman, AB, Gottlieb, DJ |
| Journal | Sleep |
| Volume | 32 |
| Issue | 6 |
| Pagination | 772-8 |
| Date Published | 2009 Jun |
| ISSN | 0161-8105 |
| Keywords | Adult, Aged, Cohort Studies, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Polysomnography, Prospective Studies, Quality of Life, Restless Legs Syndrome, Sleep Initiation and Maintenance Disorders, Statistics as Topic |
| Abstract | <p><b>STUDY OBJECTIVES: </b>Sleep disturbance is the primary clinical morbidity of restless legs syndrome (RLS). To date, sleep disturbance in RLS has been measured in (1) clinical samples with polysomnography (PSG) or (2) population-based samples by self-report. The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS.</p><p><b>DESIGN: </b>Cross-sectional observational study.</p><p><b>SETTING: </b>Community-based.</p><p><b>PARTICIPANTS: </b>3433 older men and women.</p><p><b>INTERVENTIONS: </b>None.</p><p><b>MEASUREMENTS AND RESULTS: </b>RLS was evaluated using an 8-item self-administered questionnaire based on NIH diagnostic criteria and required symptoms occurring > or = five times per month and associated with at least moderate distress. Health-related quality of life (HRQOL) was determined using the SF-36. Unattended, in-home PSG was performed. Data were assessed using general linear models with adjustment for demographic, health-related variables, and apnea-hypopnea index (AHI). Subjects with RLS had longer adjusted mean sleep latency (39.8 vs 26.4 min, P < 0.0001) and higher arousal index (20.1 vs 18.0, P = 0.0145) than those without RLS. Sleep latency increased progressively as the frequency of RLS symptoms increased from 5-15 days per month to 6-7 days per week. No differences in sleep stage percentages were observed between participants with and without RLS. Subjects with RLS also reported poorer HRQOL in all physical domains as well as in the Mental Health and Vitality domains.</p><p><b>CONCLUSIONS: </b>These novel PSG data from a nonclinical, community-based sample of individuals with RLS document sleep disturbance in the home even in individuals with intermittent symptoms.</p> |
| Alternate Journal | Sleep |
| PubMed ID | 19544754 |
| PubMed Central ID | PMC2690565 |
| Grant List | U01 HL053916 / HL / NHLBI NIH HHS / United States U01 HL063463 / HL / NHLBI NIH HHS / United States R01 HL71515 / HL / NHLBI NIH HHS / United States U01 HL53938 / HL / NHLBI NIH HHS / United States U01 HL53916 / HL / NHLBI NIH HHS / United States U01 HL053938 / HL / NHLBI NIH HHS / United States U01 HL064360 / HL / NHLBI NIH HHS / United States U01 HL53937 / HL / NHLBI NIH HHS / United States U01 HL053941 / HL / NHLBI NIH HHS / United States HL53938-07S1 / HL / NHLBI NIH HHS / United States R01 HL071515 / HL / NHLBI NIH HHS / United States U01 HL53940 / HL / NHLBI NIH HHS / United States U01 HL63463 / HL / NHLBI NIH HHS / United States U01 HL053934 / HL / NHLBI NIH HHS / United States U01 HL063429 / HL / NHLBI NIH HHS / United States U01 HL53931 / HL / NHLBI NIH HHS / United States U01 HL053937 / HL / NHLBI NIH HHS / United States U01 HL53934 / HL / NHLBI NIH HHS / United States U01 HL63429 / HL / NHLBI NIH HHS / United States U01 HL53941 / HL / NHLBI NIH HHS / United States U01 HL64360 / HL / NHLBI NIH HHS / United States U01 HL053931 / HL / NHLBI NIH HHS / United States |