You are here
Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Sun, C, Klein, R, Wong, TY |
| Journal | Ophthalmology |
| Volume | 116 |
| Issue | 10 |
| Pagination | 1913-9 |
| Date Published | 2009 Oct |
| ISSN | 1549-4713 |
| Keywords | African Americans, Age Factors, Aged, Aged, 80 and over, Blood Pressure, Cholesterol, LDL, Coronary Disease, European Continental Ancestry Group, Female, Humans, Incidence, Macular Degeneration, Male, Prospective Studies, Risk Factors, Sex Factors, Stroke, Triglycerides, United States |
| Abstract | <p><b>PURPOSE: </b>To examine the associations of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and stroke in the Cardiovascular Health Study.</p><p><b>DESIGN: </b>Population-based prospective cohort study.</p><p><b>PARTICIPANTS: </b>A total of 1786 white and African-American participants free of CHD or 2228 participants free of stroke, aged 69 to 97 years.</p><p><b>METHODS: </b>AMD was evaluated from photographs taken in 1997 and 1998.</p><p><b>MAIN OUTCOME MEASURES: </b>Incident CHD and stroke ascertained using standardized methods.</p><p><b>RESULTS: </b>Of the 1786 persons free of CHD, 303 developed incident CHD over 7 years. Participants with early AMD (n = 277) had a higher cumulative incidence of CHD than participants without early AMD (25.8% vs. 18.9%, P = 0.001). By adjusting for age, gender, race, systolic and diastolic blood pressure, hypertension status, fasting glucose, triglyceride, low-density lipoprotein cholesterol, cigarette smoking, pack years of smoking, and C-reactive protein, the presence of early AMD was associated with an increased risk of incident CHD (hazard ratio 1.57; 95% confidence interval, 1.17-2.22). Late AMD (n = 25) was not associated with incident CHD (hazard ratio 0.78; 95% confidence interval, 0.25-2.48). Among 2228 persons at risk, 198 developed incident stroke; neither early nor late AMD was associated with incident stroke.</p><p><b>CONCLUSIONS: </b>This study suggests persons with early AMD have a higher risk of CHD but not stroke in a population aged 69 to 97 years. This provides further support that AMD is associated with underlying systemic vascular disease.</p> |
| DOI | 10.1016/j.ophtha.2009.03.046 |
| Alternate Journal | Ophthalmology |
| PubMed ID | 19592102 |
| PubMed Central ID | PMC3818148 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R21-HL077166 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States R21 HL077166 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |