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Age and cystatin C in healthy adults: a collaborative study.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Age and cystatin C in healthy adults: a collaborative study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Odden, MC, Tager, IB, Gansevoort, RT, Bakker, SJL, Katz, R, Fried, LF, Newman, AB, Canada, RB, Harris, T, Sarnak, MJ, Siscovick, D, Shlipak, MG |
| Journal | Nephrol Dial Transplant |
| Volume | 25 |
| Issue | 2 |
| Pagination | 463-9 |
| Date Published | 2010 Feb |
| ISSN | 1460-2385 |
| Keywords | Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Cystatin C, Humans, Kidney, Middle Aged, Reference Values |
| Abstract | <p><b>BACKGROUND: </b>Kidney function declines with age, but a substantial portion of this decline has been attributed to the higher prevalence of risk factors for kidney disease at older ages. The effect of age on kidney function has not been well described in a healthy population across a wide age spectrum.</p><p><b>METHODS: </b>The authors pooled individual-level cross-sectional data from 18 253 persons aged 28-100 years in four studies: the Cardiovascular Health Study; the Health, Aging and Body Composition Study; the Multi-Ethnic Study of Atherosclerosis and the Prevention of Renal and Vascular End-Stage Disease cohort. Kidney function was measured by cystatin C. Clinical risk factors for kidney disease included diabetes, hypertension, obesity, smoking, coronary heart disease, cerebrovascular disease, peripheral arterial disease and heart failure.</p><p><b>RESULTS: </b>Across the age range, there was a strong, non-linear association of age with cystatin C concentration. This association was substantial, even among participants free of clinical risk factors for kidney disease; mean cystatin C levels were 46% higher in participants 80 and older compared with those <40 years (1.06 versus 0.72 mg/L, P < 0.001). Participants with one or more risk factors had higher cystatin C concentrations for a given age, and the age association was slightly stronger (P < 0.001 for age and risk factor interaction).</p><p><b>CONCLUSIONS: </b>There is a strong, non-linear association of age with kidney function, even in healthy individuals. An important area for research will be to investigate the mechanisms that lead to deterioration of kidney function in apparently healthy persons.</p> |
| DOI | 10.1093/ndt/gfp474 |
| Alternate Journal | Nephrol. Dial. Transplant. |
| PubMed ID | 19749145 |
| PubMed Central ID | PMC2904248 |
| Grant List | R01AG027002 / AG / NIA NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States N01-AG-6-2101 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01-AG-6-2103 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States N01-HC-95159 / HC / NHLBI NIH HHS / United States N01-HC-95165 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL063963 / HL / NHLBI NIH HHS / United States / / Intramural NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01-HL-63963-01A1 / HL / NHLBI NIH HHS / United States N01-HC-95169 / HC / NHLBI NIH HHS / United States DK52866 / DK / NIDDK NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-AG-6-2106 / AG / NIA NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States T32 DK007791 / DK / NIDDK NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States T32DK07791 / DK / NIDDK NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |