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Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing.
Tuesday,2012-11-06 12:18 America/Los_Angeles — eenright
| Title | Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Chami, HA, Keyes, MJ, Vita, JA, Mitchell, GF, Larson, MG, Fan, S, Vasan, RS, O'Connor, GT, Benjamin, EJ, Gottlieb, DJ |
| Journal | Vasc Med |
| Volume | 14 |
| Issue | 4 |
| Pagination | 351-60 |
| Date Published | 2009 Nov |
| ISSN | 1358-863X |
| Keywords | Adult, Aged, Aged, 80 and over, Blood Flow Velocity, Brachial Artery, Cross-Sectional Studies, Female, Humans, Hyperemia, Hypoxia, Laser-Doppler Flowmetry, Male, Middle Aged, Polysomnography, Regional Blood Flow, Severity of Illness Index, Sleep Apnea Syndromes, Ultrasonography, Vasodilation |
| Abstract | <p>Clinic-based, case-control studies linked sleep-disordered breathing (SDB) to markers of endothelial dysfunction. We attempted to validate this association in a large community-based sample, and evaluate the relation of SDB to arterial diameter and peripheral blood flow. This community-based, cross-sectional observational study included 327 men and 355 women, aged 42-83 years, from the Framingham Heart Study site of the Sleep Heart Health Study. The polysomnographically derived apnea-hypopnea index and the hypoxemia index (percent sleep time with oxyhemoglobin saturation below 90%) were used to quantify the severity of SDB. Brachial artery ultrasound measurements included baseline diameter, percent flow-mediated dilation, and baseline and hyperemic flow velocity and volume. The baseline brachial artery diameter was significantly associated with both the apnea-hypopnea index and the hypoxemia index. The association was diminished by adjustment for body mass index, but remained significant for the apnea-hypopnea index. Age-, sex-, race- and body mass index-adjusted mean diameters were 4.32, 4.33, 4.33, 4.56, 4.53 mm for those with apnea-hypopnea index < 1.5, 1.5-4.9, 5-14.9, 15-29.9, >/= 30, respectively; p = 0.03. Baseline flow measures were associated with the apnea-hypopnea index but this association was non-significant after adjusting for body mass index. No significant association was observed between measures of SDB and percent flow-mediated dilation or hyperemic flow in any model. In conclusion, this study supports a moderate association of SDB and larger baseline brachial artery diameter, which may reflect SDB-induced vascular remodeling. This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation.</p> |
| DOI | 10.1177/1358863X09105132 |
| Alternate Journal | Vasc Med |
| PubMed ID | 19808720 |
| PubMed Central ID | PMC2956304 |
| Grant List | K24-HL-04334 / HL / NHLBI NIH HHS / United States K24 HL004334-07 / HL / NHLBI NIH HHS / United States N01 HC025195 / HC / NHLBI NIH HHS / United States N01-HC 25195 / HC / NHLBI NIH HHS / United States R01 HL060040 / HL / NHLBI NIH HHS / United States R01 HL070100-04 / HL / NHLBI NIH HHS / United States U01 HL053941-14 / HL / NHLBI NIH HHS / United States K24 HL004334 / HL / NHLBI NIH HHS / United States HL70100 / HL / NHLBI NIH HHS / United States U01-HL53941 / HL / NHLBI NIH HHS / United States HL60040 / HL / NHLBI NIH HHS / United States U01 HL053941 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 HL060040-04 / HL / NHLBI NIH HHS / United States R01 HL070100 / HL / NHLBI NIH HHS / United States |