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New loci associated with kidney function and chronic kidney disease.

Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
TitleNew loci associated with kidney function and chronic kidney disease.
Publication TypeJournal Article
Year of Publication2010
AuthorsKöttgen, A, Pattaro, C, Böger, CA, Fuchsberger, C, Olden, M, Glazer, NL, Parsa, A, Gao, X, Yang, Q, Smith, AV, O'Connell, JR, Li, M, Schmidt, H, Tanaka, T, Isaacs, A, Ketkar, S, Hwang, S-J, Johnson, AD, Dehghan, A, Teumer, A, Paré, G, Atkinson, EJ, Zeller, T, Lohman, K, Cornelis, MC, Probst-Hensch, NM, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, LJ, Harris, TB, Rampersaud, E, Mitchell, BD, Arking, DE, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, BM, Zillikens, CM, Oostra, BA, Feitosa, M, Province, M, de Andrade, M, Turner, ST, Schillert, A, Ziegler, A, Wild, PS, Schnabel, RB, Wilde, S, Munzel, TF, Leak, TS, Illig, T, Klopp, N, Meisinger, C, Wichmann, H-E, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, FB, Johansson, A, Igl, W, Zaboli, G, Wild, SH, Wright, AF, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, YS, Felix, JF, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, HK, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, AN, Ridker, PM, Kardia, SLR, Blankenberg, S, Liu, Y, Curhan, GC, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Gudnason, V, Shuldiner, AR, Coresh, J, Schmidt, R, Ferrucci, L, Shlipak, MG, van Duijn, CM, Borecki, I, Krämer, BK, Rudan, I, Gyllensten, U, Wilson, JF, Witteman, JC, Pramstaller, PP, Rettig, R, Hastie, N, Chasman, DI, Kao, WH, Heid, IM, Fox, CS
JournalNat Genet
Volume42
Issue5
Pagination376-84
Date Published2010 May
ISSN1546-1718
KeywordsCohort Studies, Creatinine, Cystatin C, Diet, Europe, Genetic Markers, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Models, Genetic, Risk Factors
Abstract<p>Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.</p>
DOI10.1038/ng.568
Alternate JournalNat. Genet.
PubMed ID20383146
PubMed Central IDPMC2997674
Grant ListN01 HC055022 / HC / NHLBI NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
R01 DK075787-01A1 / DK / NIDDK NIH HHS / United States
N01 HC085086 / HC / NHLBI NIH HHS / United States
R01 HL059367-02 / HL / NHLBI NIH HHS / United States
R01 AG027002-01 / AG / NIA NIH HHS / United States
R01 DK058845 / DK / NIDDK NIH HHS / United States
K12 RR023250 / RR / NCRR NIH HHS / United States
U01 HG004728 / HG / NHGRI NIH HHS / United States
U01 HG004438 / HG / NHGRI NIH HHS / United States
N01 AG012100 / AG / NIA NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
U01 HG004726-01 / HG / NHGRI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 HG004402-01 / HG / NHGRI NIH HHS / United States
N01 AG062101 / AG / NIA NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
P60 DK079637-01 / DK / NIDDK NIH HHS / United States
R01 HL043851 / HL / NHLBI NIH HHS / United States
U01 DE018993 / DE / NIDCR NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
MC_U127561128 / / Medical Research Council / United Kingdom
U01 HG004436-01A1 / HG / NHGRI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
N02 HL64278 / HL / NHLBI NIH HHS / United States
R01 HL087652-01 / HL / NHLBI NIH HHS / United States
P30 DK072488-01 / DK / NIDDK NIH HHS / United States
U01 HG004399-01 / HG / NHGRI NIH HHS / United States
K12 RR023250-01 / RR / NCRR NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
U01 HG004424 / HG / NHGRI NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
U01 HL069757-01 / HL / NHLBI NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
R01 HL086694-01A1 / HL / NHLBI NIH HHS / United States
U01 HG004438-01 / HG / NHGRI NIH HHS / United States
R01 HL087660-01 / HL / NHLBI NIH HHS / United States
R01 AG032098-01A1 / AG / NIA NIH HHS / United States
P 20545 / / Austrian Science Fund FWF / Austria
R01 AG032098 / AG / NIA NIH HHS / United States
U01 HG004729-01 / HG / NHGRI NIH HHS / United States
R01 DK066574-01A1 / DK / NIDDK NIH HHS / United States
U01 HL084756 / HL / NHLBI NIH HHS / United States
U01 HG004729 / HG / NHGRI NIH HHS / United States
U01 GM074518-04 / GM / NIGMS NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 AG018728-01A1 / AG / NIA NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
U01 HG004422 / HG / NHGRI NIH HHS / United States
N01 HC055222 / HC / NHLBI NIH HHS / United States
N01 AG062103 / AG / NIA NIH HHS / United States
U01 HG004728-01 / HG / NHGRI NIH HHS / United States
U01 HL072515-06 / HL / NHLBI NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
R01 HL088119-01 / HL / NHLBI NIH HHS / United States
U01 HL072515 / HL / NHLBI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
R01 HL043851-09 / HL / NHLBI NIH HHS / United States
U01 HG004446-01 / HG / NHGRI NIH HHS / United States
U01 HG004738-01 / HG / NHGRI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
R01 AG027002 / AG / NIA NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
R01 DK058845-01 / DK / NIDDK NIH HHS / United States
UL1 RR025005-01 / RR / NCRR NIH HHS / United States
P30 DK063491-01 / DK / NIDDK NIH HHS / United States
U01 DE018903 / DE / NIDCR NIH HHS / United States
U01 HG004436 / HG / NHGRI NIH HHS / United States
U01 HG004423-01 / HG / NHGRI NIH HHS / United States
U01 HG004735 / HG / NHGRI NIH HHS / United States
R01 HL087700-01 / HL / NHLBI NIH HHS / United States
R01 HL087641-01 / HL / NHLBI NIH HHS / United States
U01 HG004738 / HG / NHGRI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
U01 HG004424-01 / HG / NHGRI NIH HHS / United States
U01 HG004423 / HG / NHGRI NIH HHS / United States
U01 HG004422-01 / HG / NHGRI NIH HHS / United States
U01 HL084756-01 / HL / NHLBI NIH HHS / United States
R01 HL080295-05 / HL / NHLBI NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
R01 HL117078 / HL / NHLBI NIH HHS / United States
U01 DE018993-01 / DE / NIDCR NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
R01 HL087700 / HL / NHLBI NIH HHS / United States
R01 DK066574 / DK / NIDDK NIH HHS / United States
U01 DE018903-01 / DE / NIDCR NIH HHS / United States
U01 HL069757 / HL / NHLBI NIH HHS / United States
R01 AG018728 / AG / NIA NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
U01 GM074518 / GM / NIGMS NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States
U01 HG004735-01 / HG / NHGRI NIH HHS / United States
R01 HL088119 / HL / NHLBI NIH HHS / United States
U01 HG004726 / HG / NHGRI NIH HHS / United States

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