You are here
Alcohol consumption and kidney function decline in the elderly: alcohol and kidney disease.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Alcohol consumption and kidney function decline in the elderly: alcohol and kidney disease. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Menon, V, Katz, R, Mukamal, K, Kestenbaum, B, de Boer, IH, Siscovick, DS, Sarnak, MJ, Shlipak, MG |
| Journal | Nephrol Dial Transplant |
| Volume | 25 |
| Issue | 10 |
| Pagination | 3301-7 |
| Date Published | 2010 Oct |
| ISSN | 1460-2385 |
| Keywords | Aged, Aging, Alcohol Drinking, Cohort Studies, Cystatin C, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Diseases, Male, Prospective Studies |
| Abstract | <p><b>BACKGROUND: </b>Alcohol consumption appears to be protective for cardiovascular disease; however, its relationship with kidney disease is unclear.</p><p><b>METHODS: </b>This prospective cohort study included 4343 subjects from the Cardiovascular Health Study, a longitudinal, community-based cohort of persons aged ≥65 from four US communities. We used previously defined categories based on weekly alcohol consumption: none, former, <1 drink, 1-6 drinks, 7-13 drinks and ≥14 drinks. Cystatin C was measured at baseline, year 3 and year 7; eligible subjects had at least two measures. Estimated GFR(cys) was calculated from cystatin C. The primary outcome was rapid kidney function as an annual estimated GFR (eGFR(cys)) loss >3 mL/min/1.73 m(2)/year.</p><p><b>RESULTS: </b>Eight percent of the cohort reported former alcohol use and 52% reported current alcohol consumption. During a mean follow-up of 5.6 years, 1075 (25%) participants had rapid kidney function decline. In adjusted logistic regression models, there was no association between alcohol use and kidney function decline (odds ratio, 95% confidence interval: none = reference; former = 1.18, 0.89-1.56; <1 drink = 1.20, 0.99-1.47; 1-6 = 1.18, 0.95-1.45; 7-13 = 1.10, 0.80-1.53; >14 = 0.89, 0.61-1.13). Results were similar with kidney function decline as a continuous outcome.</p><p><b>CONCLUSIONS: </b>Our results suggest that moderate alcohol consumption has neither adverse nor beneficial effects on kidney function. Although clinicians will need to consider the potential deleterious effects associated with alcohol consumption, there does not appear to be a basis for recommending that older adults discontinue or initiate light to moderate alcohol consumption to protect against kidney disease.</p> |
| DOI | 10.1093/ndt/gfq188 |
| Alternate Journal | Nephrol. Dial. Transplant. |
| PubMed ID | 20400446 |
| PubMed Central ID | PMC2948837 |
| Grant List | K23 DK067303 / DK / NIDDK NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG 027002 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States K23DK067303 / DK / NIDDK NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01 DK066488 / DK / NIDDK NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States R01 DK066488-01 / DK / NIDDK NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |