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Association between baseline kidney function and change in CRP: an analysis of the cardiovascular health study.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Association between baseline kidney function and change in CRP: an analysis of the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Rifkin, DE, Katz, R, Fried, LF, Kestenbaum, B, Jenny, NSwords, Newman, AB, Siscovick, DS, Shlipak, MG, Sarnak, MJ |
| Journal | Nephron Clin Pract |
| Volume | 115 |
| Issue | 2 |
| Pagination | c114-21 |
| Date Published | 2010 |
| ISSN | 1660-2110 |
| Keywords | Aged, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Cohort Studies, Cross-Sectional Studies, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Function Tests, Longitudinal Studies, Male, Residence Characteristics |
| Abstract | <p><b>BACKGROUND: </b>In cross-sectional analyses, C-reactive protein (CRP) levels are inversely related to levels of kidney function. The relationship between kidney function and subsequent changes in CRP is unknown.</p><p><b>METHODS: </b>We studied 4,364 individuals from the Cardiovascular Health Study, a longitudinal cohort of community-dwelling older adults. Baseline eGFRcys was estimated using cystatin C. CRP was measured at baseline and after 3 and 7 years of follow-up; slopes of change in CRP were calculated.</p><p><b>RESULTS: </b>The mean (SD) age of the cohort was 72 (5.2) years; mean (SD) eGFRcys was 78.9 (18.4) ml/min/1.73 m(2). The median (interquartile range IQR) baseline CRP was 2.39 (1.22, 4.33) mg/l; the median (IQR) yearly change in CRP was -0.0051 (-0.020 to 0.27) mg/l/year. After adjustment for demographic characteristics and the initial level of CRP, each standard deviation lower baseline eGFR was associated with a small and non-significant yearly increase in CRP (0.032 mg/l/year; 95% CI: -0.005 to 0.070, p = 0.094).</p><p><b>CONCLUSIONS: </b>We did not find a relationship between eGFR and subsequent changes in CRP. The association between kidney function and CRP in cross-sectional analyses may reflect unmeasured confounding by atherosclerosis; alternatively, the burden of comorbidity and interval mortality in this population may have masked a stronger longitudinal association between kidney function and change in CRP. Further study in younger populations may clarify whether impaired kidney function leads to change in inflammation over time.</p> |
| DOI | 10.1159/000312874 |
| Alternate Journal | Nephron Clin Pract |
| PubMed ID | 20413990 |
| PubMed Central ID | PMC2892648 |
| Grant List | R01-AG-027002 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |