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Parity and the association with diabetes in older women.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Parity and the association with diabetes in older women. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Fowler-Brown, AG, de Boer, IH, Catov, JM, Carnethon, MR, Kamineni, A, Kuller, LH, Siscovick, DS, Mukamal, KJ |
| Journal | Diabetes Care |
| Volume | 33 |
| Issue | 8 |
| Pagination | 1778-82 |
| Date Published | 2010 Aug |
| ISSN | 1935-5548 |
| Keywords | Aged, Body Weight, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Parity, Pregnancy, Socioeconomic Factors |
| Abstract | <p><b>OBJECTIVE: </b>To examine the relationship of parity with diabetes and markers of glucose homeostasis in older women.</p><p><b>RESEARCH DESIGN AND METHODS: </b>We used data from the female participants in the Cardiovascular Health Study, a longitudinal cohort of adults aged >or=65 years. These data included an assessment of parity (baseline) and fasting serum levels of glucose, insulin, and medication use (baseline and follow-up). We estimated both the cross-sectional relationship of parity with baseline diabetes and the relationship of parity with incident diabetes.</p><p><b>RESULTS: </b>In unadjusted analyses, women with grand multiparity (>or=5 live births) had a higher prevalence of diabetes at baseline compared with those with fewer births and with nulliparous women (25 vs. 12 vs. 15%; P < 0.001). In regression models controlling for age and race, grand multiparity was associated with increased prevalence of diabetes (prevalence ratio 1.57 [95% CI 1.20-2.06]); with addition of demographic and clinical factors to the model, the association was attenuated (1.33 [1.00-1.77]). In final models that included body anthropometrics, the association was no longer significant (1.21 [0.86-1.49]). In those without diabetes at baseline, parity was not associated with incident diabetes or with fasting glucose; however, there was a modest association of parity with fasting insulin and homeostasis assessment model of insulin resistance.</p><p><b>CONCLUSIONS: </b>Grand multiparity is associated with diabetes in elderly women in cross-sectional analyses. This relationship seems to be confounded and/or mediated by variation in body weight and sociodemographic factors by parity status. In older nondiabetic women, higher parity does not pose an ongoing risk of developing diabetes.</p> |
| DOI | 10.2337/dc10-0015 |
| Alternate Journal | Diabetes Care |
| PubMed ID | 20424225 |
| PubMed Central ID | PMC2909061 |
| Grant List | P30 AG024827 / AG / NIA NIH HHS / United States R01 AG-15928 / AG / NIA NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States P30-AG-024827 / AG / NIA NIH HHS / United States R01-HL-075366 / HL / NHLBI NIH HHS / United States U01-HL-080295 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01-AG-20098 / AG / NIA NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |