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Obesity is linked with lower brain volume in 700 AD and MCI patients.
Tuesday,2012-11-06 12:19 America/Los_Angeles — eenright
| Title | Obesity is linked with lower brain volume in 700 AD and MCI patients. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Ho, AJ, Raji, CA, Becker, JT, Lopez, OL, Kuller, LH, Hua, X, Lee, S, Hibar, D, Dinov, ID, Stein, JL, Jack, CR, Weiner, MW, Toga, AW, Thompson, PM |
| Corporate/Institutional Authors | Cardiovascular Health Study,, ADNI, |
| Journal | Neurobiol Aging |
| Volume | 31 |
| Issue | 8 |
| Pagination | 1326-39 |
| Date Published | 2010 Aug |
| ISSN | 1558-1497 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Body Mass Index, Brain, Cognition Disorders, Cohort Studies, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Obesity, Organ Size, Prospective Studies, Risk Factors |
| Abstract | <p>Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.</p> |
| DOI | 10.1016/j.neurobiolaging.2010.04.006 |
| Alternate Journal | Neurobiol. Aging |
| PubMed ID | 20570405 |
| PubMed Central ID | PMC3197833 |
| Grant List | K01 AG030514 / AG / NIA NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States R01 EB007813 / EB / NIBIB NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States U19 AG010483 / AG / NIA NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States U54-RR021813 / RR / NCRR NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States R01 HD050735 / HD / NICHD NIH HHS / United States AG05133 / AG / NIA NIH HHS / United States R01 EB008432 / EB / NIBIB NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States U54 RR021813 / RR / NCRR NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States R01 EB008281 / EB / NIBIB NIH HHS / United States AG20098 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |