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European ancestry as a risk factor for atrial fibrillation in African Americans.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | European ancestry as a risk factor for atrial fibrillation in African Americans. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Marcus, GM, Alonso, A, Peralta, CA, Lettre, G, Vittinghoff, E, Lubitz, SA, Fox, ER, Levitzky, YS, Mehra, R, Kerr, KF, Deo, R, Sotoodehnia, N, Akylbekova, M, Ellinor, PT, Paltoo, DN, Soliman, EZ, Benjamin, EJ, Heckbert, SR |
| Corporate/Institutional Authors | Candidate-Gene Association Resource (CARe) Study, |
| Journal | Circulation |
| Volume | 122 |
| Issue | 20 |
| Pagination | 2009-15 |
| Date Published | 2010 Nov 16 |
| ISSN | 1524-4539 |
| Keywords | African Americans, Aged, Atrial Fibrillation, European Continental Ancestry Group, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic or environmental factors. Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF.</p><p><b>METHODS AND RESULTS: </b>We studied whites (n=4543) and African Americans (n=822) in the Cardiovascular Health Study (CHS) and whites (n=10 902) and African Americans (n=3517) in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517). Percent European ancestry in African Americans was estimated with 1747 ancestry informative markers from the Illumina custom ITMAT-Broad-CARe array. Among African Americans without baseline AF, 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF. A meta-analysis from the 2 studies revealed that every 10% increase in European ancestry increased the risk of AF by 13% (hazard ratio, 1.13; 95% confidence interval, 1.03 to 1.23; P=0.007). After adjustment for potential confounders, European ancestry remained a predictor of incident AF in each cohort alone, with a combined estimated hazard ratio for each 10% increase in European ancestry of 1.17 (95% confidence interval, 1.07 to 1.29; P=0.001). A second analysis using 3192 ancestry informative markers from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results.</p><p><b>CONCLUSIONS: </b>European ancestry predicted risk of incident AF. Our study suggests that investigating genetic variants contributing to differential AF risk in individuals of African versus European ancestry will be informative.</p> |
| DOI | 10.1161/CIRCULATIONAHA.110.958306 |
| Alternate Journal | Circulation |
| PubMed ID | 21098467 |
| PubMed Central ID | PMC3058884 |
| Grant List | (N01-HC-95163 / HC / NHLBI NIH HHS / United States N01HC55020 / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States N01-HB-72992 / HB / NHLBI NIH HHS / United States N01-HC-25195 / HC / NHLBI NIH HHS / United States N01-HB-97068 / HB / NHLBI NIH HHS / United States N01-HB-97053 / HB / NHLBI NIH HHS / United States N01-HB-72997 / HB / NHLBI NIH HHS / United States N01-HB-73003 / HB / NHLBI NIH HHS / United States N01-HC-45205 / HC / NHLBI NIH HHS / United States RC1-HL01056 / HL / NHLBI NIH HHS / United States N01-HC-95162 / HC / NHLBI NIH HHS / United States R21 DA027021 / DA / NIDA NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States K23 HL079114 / HL / NHLBI NIH HHS / United States U01 HL053916 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States R01 HL046380 / HL / NHLBI NIH HHS / United States K24 HL105780 / HL / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States U01 HL063463 / HL / NHLBI NIH HHS / United States N01-HB-97064 / HB / NHLBI NIH HHS / United States N01HC48049 / HL / NHLBI NIH HHS / United States R01HL092577-01A1 / HL / NHLBI NIH HHS / United States M01RR00080 / RR / NCRR NIH HHS / United States R01 HL104156 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States R01 HL092577 / HL / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01HC45205 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-95168 / HC / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States N01-HB-73002 / HB / NHLBI NIH HHS / United States T32 HL007575 / HL / NHLBI NIH HHS / United States KL2 RR024130 / RR / NCRR NIH HHS / United States N01-HC-45204 / HC / NHLBI NIH HHS / United States N01-HB-72993 / HB / NHLBI NIH HHS / United States L30 HL078035-04 / HL / NHLBI NIH HHS / United States N01-HB-97070 / HB / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01-HB-97056 / HB / NHLBI NIH HHS / United States N01-HB-72982 / HB / NHLBI NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States N01-HB-73000 / HB / NHLBI NIH HHS / United States N01-HC-95159 / HC / NHLBI NIH HHS / United States HL053934 / HL / NHLBI NIH HHS / United States RC1 HL099452 / HL / NHLBI NIH HHS / United States R01 HL076784 / HL / NHLBI NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States HHSN268200625226C / / PHS HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States 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United States N01 HC085084 / HC / NHLBI NIH HHS / United States N01HC48050 / HL / NHLBI NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC05187 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01-HC-95172 / HC / NHLBI NIH HHS / United States N01HC48047 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC95171 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 HL071205 / HL / NHLBI NIH HHS / United States N01-HB-72991 / HB / NHLBI NIH HHS / United States N01-HB-97072 / HB / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-95161 / HC / NHLBI NIH HHS / United States N01-HC-95100 / HC / NHLBI NIH HHS / United States N01HC45204 / HL / NHLBI NIH HHS / United States N01-HB-97058 / HB / NHLBI NIH HHS / United States U01 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