CHS Home | Welcome New Investigators | Directory | Contact Us

 

You are here

Home

Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study.

Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
TitleAssociation of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study.
Publication TypeJournal Article
Year of Publication2011
AuthorsZakai, NA, Lange, L, Longstreth, WT, O'Meara, ES, Kelley, JL, Fornage, M, Nikerson, D, Cushman, M, Reiner, AP
JournalJ Thromb Haemost
Volume9
Issue2
Pagination267-74
Date Published2011 Feb
ISSN1538-7836
KeywordsBlood Coagulation Factors, Cardiovascular Diseases, Cohort Studies, Factor VII, Female, Humans, Inflammation, Male, Polymorphism, Single Nucleotide, Prospective Studies, Risk Factors, Stroke
Abstract<p><b>BACKGROUND: </b>Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are inconclusive.</p><p><b>OBJECTIVES: </b>To test the associations between 736 single-nucleotide polymorphisms (SNPs) between tagging haplotype patterns of 130 coagulation and inflammation genes, and stroke events, in the 5888 participants aged ≥ 65 years of the observational Cardiovascular Health Study cohort.</p><p><b>PATIENTS/METHODS: </b>With 16 years of follow-up, age-adjusted and sex-adjusted Cox models were used to estimate associations of SNPs and FVIIc levels with future stroke.</p><p><b>RESULTS: </b>Eight hundred and fifteen strokes occurred in 5255 genotyped participants without baseline stroke (748 ischemic strokes; 586 among whites). Among whites, six SNPs were associated with stroke, with a nominal P-value of < 0.01: rs6046 and rs3093261 (F7); rs4918851 and rs3781387 (HABP2); and rs3138055 (NFKB1A) and rs4648004 (NFKB1). Two of these SNPs were associated with FVIIc levels (units of percentage activity): rs6046 (β = -18.5, P = 2.38 × 10(-83)) and rs3093261 (β = 2.99, P = 3.93 × 10(-6)). After adjustment for age, sex, race, and cardiovascular risk factors, the association of FVIIc quintiles (Q) with stroke were as follows (hazard ratio; 95% confidence interval): Q1, reference; Q2, 1.4, 1.1-1.9); Q3, 1.1, 0.8-1.5); Q4, 1.5, 1.1-2.0); and Q5, 1.6, 1.2-2.2). Associations between SNPs and stroke were independent of FVIIc levels.</p><p><b>CONCLUSIONS: </b>Variations in FVII-related genes and FVIIc levels were associated with risk of incident ischemic stroke in this elderly cohort, suggesting a potential causal role for FVII in stroke etiology.</p>
DOI10.1111/j.1538-7836.2010.04149.x
Alternate JournalJ. Thromb. Haemost.
PubMed ID21114618
PubMed Central IDPMC3030667
Grant ListN01 HC085086 / HC / NHLBI NIH HHS / United States
P30 AG024827 / AG / NIA NIH HHS / United States
R01 AG020098-01 / AG / NIA NIH HHS / United States
R01 HL059367-02 / HL / NHLBI NIH HHS / United States
R01 AG-15928 / AG / NIA NIH HHS / United States
P30 AG024827-05 / AG / NIA NIH HHS / United States
R01 HL075366 / HL / NHLBI NIH HHS / United States
R01 HL059367-05 / HL / NHLBI NIH HHS / United States
R01 AG015928-02 / AG / NIA NIH HHS / United States
P30 AG024827-02 / AG / NIA NIH HHS / United States
P30 AG024827-01 / AG / NIA NIH HHS / United States
U01 HL080295-04 / HL / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
R01 HL059367-03 / HL / NHLBI NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
R01 AG023629-03 / AG / NIA NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
R01 AG020098-02 / AG / NIA NIH HHS / United States
R01 HL-075366 / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
R01 HL071862-01A1 / HL / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
R01 HL059367-04 / HL / NHLBI NIH HHS / United States
R01 AG027058-04 / AG / NIA NIH HHS / United States
R01 HL59367 / HL / NHLBI NIH HHS / United States
P30-AG-024827 / AG / NIA NIH HHS / United States
U01 HL080295-01 / HL / NHLBI NIH HHS / United States
R01 AG020098-03 / AG / NIA NIH HHS / United States
R01 AG023629-02 / AG / NIA NIH HHS / United States
R01 HL-071862 / HL / NHLBI NIH HHS / United States
R01 HL059367-10 / HL / NHLBI NIH HHS / United States
R01 AG027058-03 / AG / NIA NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
U01 HL080295-03 / HL / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
P30 AG024827-06 / AG / NIA NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
AG-027058 / AG / NIA NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
P30 AG024827-08 / AG / NIA NIH HHS / United States
R01 AG020098-04 / AG / NIA NIH HHS / United States
P30 AG024827-03 / AG / NIA NIH HHS / United States
R01 HL059367-08 / HL / NHLBI NIH HHS / United States
N01 HC055222 / HC / NHLBI NIH HHS / United States
R01 AG027058-01 / AG / NIA NIH HHS / United States
R01 HL071862-03 / HL / NHLBI NIH HHS / United States
P30 AG024827-06S2 / AG / NIA NIH HHS / United States
U01 HL080295-02 / HL / NHLBI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
R01 HL071862-04 / HL / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
R01 HL071862 / HL / NHLBI NIH HHS / United States
R01 AG-20098 / AG / NIA NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
R01 AG023629-01 / AG / NIA NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
R01 HL059367-09 / HL / NHLBI NIH HHS / United States
R01 AG027058-02 / AG / NIA NIH HHS / United States
P30 AG024827-04 / AG / NIA NIH HHS / United States
P30 AG024827-07 / AG / NIA NIH HHS / United States
R01 HL071862-02 / HL / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
R01 HL059367-06 / HL / NHLBI NIH HHS / United States
R01 AG027058 / AG / NIA NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R56 AG023629 / AG / NIA NIH HHS / United States
N01-HC-85084 / HC / NHLBI NIH HHS / United States
R01 HL059367-07 / HL / NHLBI NIH HHS / United States
R01 AG020098-05 / AG / NIA NIH HHS / United States
R01 AG023629-04 / AG / NIA NIH HHS / United States

© 2001 - 2020 CHS Coordinating Center University of Washington, Seattle, WA

Privacy | Terms