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Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Kizer, JR, Biggs, ML, Ix, JH, Mukamal, KJ, Zieman, SJ, de Boer, IH, Mozaffarian, D, Barzilay, JI, Strotmeyer, ES, Luchsinger, JA, Elkind, MSV, Longstreth, WT, Kuller, LH, Siscovick, DS |
| Journal | Am J Epidemiol |
| Volume | 173 |
| Issue | 1 |
| Pagination | 10-25 |
| Date Published | 2011 Jan 01 |
| ISSN | 1476-6256 |
| Keywords | Adiposity, Age Factors, Aged, Aged, 80 and over, Brain Ischemia, Coronary Disease, Female, Humans, Incidence, Male, Middle Aged, Obesity, Prevalence, Retrospective Studies, Risk Factors, Sex Factors, United States |
| Abstract | <p>The relation between measures of general and central adiposity and individual cardiovascular endpoints remains understudied in older adults. This study investigated the association of measures of body size and composition with incident ischemic stroke or coronary heart disease (1989-2007) in 3,754 community-dwelling US adults aged 65-100 years. Standardized anthropometry and bioelectric impedance measurements were obtained at baseline. Body mass index at age 50 years (BMI50) was calculated on the basis of recalled weight. Although only waist/hip ratio was significantly associated with ischemic stroke in quintile analysis in women, dichotomized body mass index (BMI) (≥ 30 kg/m²) was the only significant predictor in men. For coronary heart disease, there were significant positive adjusted associations for all adiposity measures, without interaction by sex. This was true for both quintiles and conventional cutpoints for obesity, although BMI-defined overweight (25-29.9 kg/m² was significant at midlife but not at baseline. Strengths of association for extreme quintiles (quintile 5 vs. quintile 1) were broadly comparable, but the highest effect estimates were for waist/hip ratio (hazard ratio = 1.56, 95% confidence interval: 1.25, 1.94) and BMI50 (hazard ratio = 1.71, 95% confidence interval: 1.37, 2.14), both of which remained significant after adjustment for mediators, BMI, or each other. Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints.</p> |
| DOI | 10.1093/aje/kwq311 |
| Alternate Journal | Am. J. Epidemiol. |
| PubMed ID | 21123850 |
| PubMed Central ID | PMC3025638 |
| Grant List | N01 HC085086 / HC / NHLBI NIH HHS / United States N01 HC-35129 / HC / NHLBI NIH HHS / United States N01 HC-85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States N01 HC-85082 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC-85085 / HC / NHLBI NIH HHS / United States R01 HL-094555 / HL / NHLBI NIH HHS / United States N01 HC-85081 / HC / NHLBI NIH HHS / United States N01 HC-85079 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01 HC-85086 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01 HC-85083 / HC / NHLBI NIH HHS / United States N01 HC-45133 / HC / NHLBI NIH HHS / United States N01 HC-85084 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |