CHS Home | Welcome New Investigators | Directory | Contact Us

 

You are here

Home

Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
TitleHealth and function of participants in the Long Life Family Study: A comparison with other cohorts.
Publication TypeJournal Article
Year of Publication2011
AuthorsNewman, AB, Glynn, NW, Taylor, CA, Sebastiani, P, Perls, TT, Mayeux, R, Christensen, K, Zmuda, JM, Barral, S, Lee, JH, Simonsick, EM, Walston, JD, Yashin, AI, Hadley, E
JournalAging (Albany NY)
Volume3
Issue1
Pagination63-76
Date Published2011 Jan
ISSN1945-4589
KeywordsAged, Aged, 80 and over, Aging, Blood Pressure, Cardiovascular Diseases, Cohort Studies, Female, Gait, Humans, Longevity, Male, Middle Aged, Psychomotor Performance, Research Design
Abstract<p>Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.</p>
DOI10.18632/aging.100242
Alternate JournalAging (Albany NY)
PubMed ID21258136
PubMed Central IDPMC3047140
Grant ListU01 AG023712-05 / AG / NIA NIH HHS / United States
R01 HL075366-04 / HL / NHLBI NIH HHS / United States
N01 HC085086 / HC / NHLBI NIH HHS / United States
U01 AG023712 / AG / NIA NIH HHS / United States
P30 AG024827 / AG / NIA NIH HHS / United States
R01 AG020098-07 / AG / NIA NIH HHS / United States
R01 AG020098-01 / AG / NIA NIH HHS / United States
R01 AG-15928 / AG / NIA NIH HHS / United States
P30 AG024827-05 / AG / NIA NIH HHS / United States
K24 AG025727-02 / AG / NIA NIH HHS / United States
UL1 TR000005 / TR / NCATS NIH HHS / United States
U01 AG023746-02S2 / AG / NIA NIH HHS / United States
R01 HL075366 / HL / NHLBI NIH HHS / United States
U01 AG023746-01 / AG / NIA NIH HHS / United States
U01 AG023746-03 / AG / NIA NIH HHS / United States
U01 AG023744 / AG / NIA NIH HHS / United States
R01 AG015928-02 / AG / NIA NIH HHS / United States
U01 AG023749-04 / AG / NIA NIH HHS / United States
K24 AG025727-04S1 / AG / NIA NIH HHS / United States
P30 AG024827-02 / AG / NIA NIH HHS / United States
P30 AG024827-01 / AG / NIA NIH HHS / United States
N01 HC085081 / HC / NHLBI NIH HHS / United States
U01 HL080295-04 / HL / NHLBI NIH HHS / United States
U01 AG023755-07 / AG / NIA NIH HHS / United States
U01 AG023749-06 / AG / NIA NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
K24 AG025727-03 / AG / NIA NIH HHS / United States
U01 AG023749-02S1 / AG / NIA NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
U01 AG023712-06 / AG / NIA NIH HHS / United States
U01 AG023712-05S1 / AG / NIA NIH HHS / United States
U01 AG023746-03S1 / AG / NIA NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
R01 AG020098-02 / AG / NIA NIH HHS / United States
R01 HL-075366 / HL / NHLBI NIH HHS / United States
U01 AG023755-05S2 / AG / NIA NIH HHS / United States
U01 AG023746-05S1 / AG / NIA NIH HHS / United States
U01 AG023712-02 / AG / NIA NIH HHS / United States
U01 AG023755-02S1 / AG / NIA NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
U01 AG023755-04 / AG / NIA NIH HHS / United States
N01 HC085083 / HC / NHLBI NIH HHS / United States
R01 AG027058-04 / AG / NIA NIH HHS / United States
U01 AG023746-04 / AG / NIA NIH HHS / United States
U01 AG023746-04S1 / AG / NIA NIH HHS / United States
K24 AG025727-04 / AG / NIA NIH HHS / United States
P30-AG-024827 / AG / NIA NIH HHS / United States
U01 HL080295-01 / HL / NHLBI NIH HHS / United States
R01 AG020098-03 / AG / NIA NIH HHS / United States
N01 HC085085 / HC / NHLBI NIH HHS / United States
R01 AG027058-03 / AG / NIA NIH HHS / United States
R01 AG020098-08 / AG / NIA NIH HHS / United States
K24 AG025727 / AG / NIA NIH HHS / United States
U01 AG023749-05 / AG / NIA NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
U01 HL080295-03 / HL / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
P30 AG024827-06 / AG / NIA NIH HHS / United States
U01 AG023746-02S3 / AG / NIA NIH HHS / United States
U01 AG023755-02S2 / AG / NIA NIH HHS / United States
R01 HL075366-05 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
U01 AG023712-02S1 / AG / NIA NIH HHS / United States
AG-027058 / AG / NIA NIH HHS / United States
R01 HL075366-03 / HL / NHLBI NIH HHS / United States
N01 HC085082 / HC / NHLBI NIH HHS / United States
N01 HC085080 / HC / NHLBI NIH HHS / United States
U01 AG023749-02 / AG / NIA NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
P30 AG024827-08 / AG / NIA NIH HHS / United States
U01 AG023749-01 / AG / NIA NIH HHS / United States
R01 AG020098-04 / AG / NIA NIH HHS / United States
P30 AG024827-03 / AG / NIA NIH HHS / United States
K24 AG025727-01A1 / AG / NIA NIH HHS / United States
R01 AG020098-06A2 / AG / NIA NIH HHS / United States
U01 AG023749 / AG / NIA NIH HHS / United States
N01 HC055222 / HC / NHLBI NIH HHS / United States
R01 HL075366-01A1 / HL / NHLBI NIH HHS / United States
R01 AG027058-01 / AG / NIA NIH HHS / United States
U01-AG023712 / AG / NIA NIH HHS / United States
P30 AG024827-06S2 / AG / NIA NIH HHS / United States
U01 AG023755-05S1 / AG / NIA NIH HHS / United States
U01 AG023755-01 / AG / NIA NIH HHS / United States
U01 AG023755 / AG / NIA NIH HHS / United States
U01 HL080295-02 / HL / NHLBI NIH HHS / United States
U01 AG023746-05 / AG / NIA NIH HHS / United States
U01 AG023749-05S2 / AG / NIA NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
U01 AG023746-06 / AG / NIA NIH HHS / United States
R01 AG020098-09 / AG / NIA NIH HHS / United States
U01 AG023712-01 / AG / NIA NIH HHS / United States
U01 AG023712-04 / AG / NIA NIH HHS / United States
R01 AG-20098 / AG / NIA NIH HHS / United States
U01 AG023755-05 / AG / NIA NIH HHS / United States
N01 HC085084 / HC / NHLBI NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
R01 HL075366-02 / HL / NHLBI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
U01 AG023755-02 / AG / NIA NIH HHS / United States
U01 AG023746 / AG / NIA NIH HHS / United States
5K24AG025727 / AG / NIA NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
R01 AG027058-02 / AG / NIA NIH HHS / United States
U01-AG23744 / AG / NIA NIH HHS / United States
U01 AG023749-05S1 / AG / NIA NIH HHS / United States
U01 AG023746-02S1 / AG / NIA NIH HHS / United States
P30 AG024827-04 / AG / NIA NIH HHS / United States
P30 AG024827-07 / AG / NIA NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
U01 AG023749-03 / AG / NIA NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
U01 AG023746-02 / AG / NIA NIH HHS / United States
R01 AG027058 / AG / NIA NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
U01 AG023755-06 / AG / NIA NIH HHS / United States
U01-AG023755 / AG / NIA NIH HHS / United States
U01 AG023712-03 / AG / NIA NIH HHS / United States
U01-AG023746 / AG / NIA NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R56 AG023629 / AG / NIA NIH HHS / United States
U01 AG023755-03 / AG / NIA NIH HHS / United States
U01-AG023749 / AG / NIA NIH HHS / United States
K24 AG025727-05S1 / AG / NIA NIH HHS / United States
K24 AG025727-05 / AG / NIA NIH HHS / United States
U01 AG023712-07 / AG / NIA NIH HHS / United States
U01 AG023749-07 / AG / NIA NIH HHS / United States
R01 AG020098-05 / AG / NIA NIH HHS / United States

© 2001 - 2020 CHS Coordinating Center University of Washington, Seattle, WA

Privacy | Terms