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Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Johnson, AD, Newton-Cheh, C, Chasman, DI, Ehret, GB, Johnson, T, Rose, L, Rice, K, Verwoert, GC, Launer, LJ, Gudnason, V, Larson, MG, Chakravarti, A, Psaty, BM, Caulfield, M, van Duijn, CM, Ridker, PM, Munroe, PB, Levy, D |
| Corporate/Institutional Authors | Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium,, Global BPgen Consortium, Women's Genome Health Study, |
| Journal | Hypertension |
| Volume | 57 |
| Issue | 5 |
| Pagination | 903-10 |
| Date Published | 2011 May |
| ISSN | 1524-4563 |
| Keywords | Alleles, Angiotensinogen, Antihypertensive Agents, Blood Pressure, Female, Genetic Predisposition to Disease, Genotype, Humans, Hypertension, Male, Pharmacogenetics, Polymorphism, Single Nucleotide, Receptors, Adrenergic, beta-1 |
| Abstract | <p>We previously conducted genome-wide association meta-analysis of systolic blood pressure, diastolic blood pressure, and hypertension in 29,136 people from 6 cohort studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Here we examine associations of these traits with 30 gene regions encoding known antihypertensive drug targets. We find nominal evidence of association of ADRB1, ADRB2, AGT, CACNA1A, CACNA1C, and SLC12A3 polymorphisms with 1 or more BP traits in the Cohorts for Heart and Aging Research in Genomic Epidemiology genome-wide association meta-analysis. We attempted replication of the top meta-analysis single nucleotide polymorphisms for these genes in the Global BPgen Consortium (n=34,433) and the Women's Genome Health Study (n=23,019) and found significant results for rs1801253 in ADRB1 (Arg389Gly), with the Gly allele associated with a lower mean systolic blood pressure (β: 0.57 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=4.7×10(-10)), diastolic blood pressure (β: 0.36 mm Hg; SE: 0.06 mm Hg; meta-analysis: P=9.5×10(-10)), and prevalence of hypertension (β: 0.06 mm Hg; SE: 0.02 mm Hg; meta-analysis: P=3.3×10(-4)). Variation in AGT (rs2004776) was associated with systolic blood pressure (β: 0.42 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=3.8×10(-6)), as well as diastolic blood pressure (P=5.0×10(-8)) and hypertension (P=3.7×10(-7)). A polymorphism in ACE (rs4305) showed modest replication of association with increased hypertension (β: 0.06 mm Hg; SE: 0.01 mm Hg; meta-analysis: P=3.0×10(-5)). Two loci, ADRB1 and AGT, contain single nucleotide polymorphisms that reached a genome-wide significance threshold in meta-analysis for the first time. Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions.</p> |
| DOI | 10.1161/HYPERTENSIONAHA.110.158667 |
| Alternate Journal | Hypertension |
| PubMed ID | 21444836 |
| PubMed Central ID | PMC3099407 |
| Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States M01-RR00425 / RR / NCRR NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States N02-HL-6-4278 / HL / NHLBI NIH HHS / United States N01-HC-25195 / HC / NHLBI NIH HHS / United States N01 HC055022 / HC / NHLBI NIH HHS / United States G9521010 / / Medical Research Council / United Kingdom R01 HL059367-02 / HL / NHLBI NIH HHS / United States N01AG12100 / AG / NIA NIH HHS / United States N01 AG012100 / AG / NIA NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States U01 HG004402-01 / HG / NHGRI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01 HC055018 / HC / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States R37 HL051021-06 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States R01 HL086694-01A1 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States N01 HC055019 / HC / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States Z01 HL006001-02 / / Intramural NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States ZIA HL006001-04 / / Intramural NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States U10 HL054512-05 / HL / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States R37HL051021 / HL / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States N01 HC055015 / HC / NHLBI NIH HHS / United States N01 HC055021 / HC / NHLBI NIH HHS / United States M01 RR000425 / RR / NCRR NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 HL087641-01 / HL / NHLBI NIH HHS / United States DK063491 / DK / NIDDK NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01 HC055020 / HC / NHLBI NIH HHS / United States U10HL054512 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States Z01 HL006001-01 / / Intramural NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R37 HL051021 / HL / NHLBI NIH HHS / United States N01 HC055016 / HC / NHLBI NIH HHS / United States ZIA HL006001-03 / / Intramural NIH HHS / United States U10 HL054512 / HL / NHLBI NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States |