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The risk of Parkinson disease associated with urate in a community-based cohort of older adults.
Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
| Title | The risk of Parkinson disease associated with urate in a community-based cohort of older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Jain, S, Ton, TG, Boudreau, RM, Yang, M, Thacker, EL, Studenski, S, Longstreth, WT, Strotmeyer, ES, Newman, AB |
| Journal | Neuroepidemiology |
| Volume | 36 |
| Issue | 4 |
| Pagination | 223-9 |
| Date Published | 2011 |
| ISSN | 1423-0208 |
| Keywords | Aged, California, Cohort Studies, Female, Humans, Male, Maryland, North Carolina, Parkinson Disease, Pennsylvania, Prospective Studies, Risk Factors, Sex Distribution, Sex Factors, Uric Acid |
| Abstract | <p><b>BACKGROUND/AIMS: </b>Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults.</p><p><b>METHODS: </b>The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (<300 µmol/l), middle (300-500 µmol/l), and high (>500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD.</p><p><b>RESULTS: </b>Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate <300 µmol/l (OR 1.69, 95% CI 1.03-2.78) but not for urate >500 µmol/l (OR 1.55, 95% CI 0.72-3.32) in men. A negative linear term was significant for urate <500 µmol/l, and across the entire range a convex quadratic term was significant.</p><p><b>CONCLUSIONS: </b>Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk.</p> |
| DOI | 10.1159/000327748 |
| Alternate Journal | Neuroepidemiology |
| PubMed ID | 21677446 |
| PubMed Central ID | PMC3124452 |
| Grant List | T32 HL007902 / HL / NHLBI NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States P30 AG-024827 / AG / NIA NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States R01 AG-15928 / AG / NIA NIH HHS / United States UL1 TR000005 / TR / NCATS NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States N01 HC-35129 / HC / NHLBI NIH HHS / United States U01 HL-080295 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC075150 / HC / NHLBI NIH HHS / United States R01 HL-075366 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC-85079 / HC / NHLBI NIH HHS / United States KL2 RR024154 / RR / NCRR NIH HHS / United States R01 AG-023629 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01 HC-85086 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01 HC-45133 / HC / NHLBI NIH HHS / United States HL007902 / HL / NHLBI NIH HHS / United States R01 AG-20098 / AG / NIA NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States 1 KL2 RR024154-01 / RR / NCRR NIH HHS / United States R01 AG-027058 / AG / NIA NIH HHS / United States |