CHS Home | Welcome New Investigators | Directory | Contact Us

 

You are here

Home

Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.

Tuesday,2012-11-06 12:25 America/Los_Angeles — eenright
TitleIdentification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
Publication TypeJournal Article
Year of Publication2011
AuthorsArking, DE, M Junttila, J, Goyette, P, Huertas-Vazquez, A, Eijgelsheim, M, Blom, MT, Newton-Cheh, C, Reinier, K, Teodorescu, C, Uy-Evanado, A, Carter-Monroe, N, Kaikkonen, KS, Kortelainen, M-L, Boucher, G, Lagacé, C, Moes, A, Zhao, XQ, Kolodgie, F, Rivadeneira, F, Hofman, A, Witteman, JCM, Uitterlinden, AG, Marsman, RF, Pazoki, R, Bardai, A, Koster, RW, Dehghan, A, Hwang, S-J, Bhatnagar, P, Post, W, Hilton, G, Prineas, RJ, Li, M, Köttgen, A, Ehret, G, Boerwinkle, E, Coresh, J, Kao, LWH, Psaty, BM, Tomaselli, GF, Sotoodehnia, N, Siscovick, DS, Burke, GL, Marbán, E, Spooner, PM, Cupples, AL, Jui, J, Gunson, K, Kesaniemi, AY, Wilde, AAM, Tardif, J-C, O'Donnell, CJ, Bezzina, CR, Virmani, R, Stricker, BHCH, Tan, HL, Albert, CM, Chakravarti, A, Rioux, JD, Huikuri, HV, Chugh, SS
JournalPLoS Genet
Volume7
Issue6
Paginatione1002158
Date Published2011 Jun
ISSN1553-7404
KeywordsAdult, Aged, Alleles, Chromosomes, Human, Pair 2, Death, Sudden, Cardiac, European Continental Ancestry Group, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Myocardial Contraction, Polymorphism, Single Nucleotide
Abstract<p>Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies, and identify the BAZ2B locus as associated with SCD (P = 1.8×10(-10)). The risk allele, while ancestral, has a frequency of ~1.4%, suggesting strong negative selection and increases risk for SCD by 1.92-fold per allele (95% CI 1.57-2.34). We also tested the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals). Consistent with epidemiological studies showing increased risk of SCD with prolonged QRS/QT intervals, the interval-prolonging alleles are in aggregate associated with increased risk for SCD (P = 0.006).</p>
DOI10.1371/journal.pgen.1002158
Alternate JournalPLoS Genet.
PubMed ID21738491
PubMed Central IDPMC3128111
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CA-34944 / CA / NCI NIH HHS / United States
HL-34595 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
HL-46959 / HL / NHLBI NIH HHS / United States
N01-HC-80007 / HC / NHLBI NIH HHS / United States
HL-26490 / HL / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
R01 HL105170-01 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
CA 97193 / CA / NCI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
P01 CA055075 / CA / NCI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
R01 HL088416 / HL / NHLBI NIH HHS / United States
R01 HL034595 / HL / NHLBI NIH HHS / United States
CA-87969 / CA / NCI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
CA55075 / CA / NCI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
HL-34594 / HL / NHLBI NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
CA 40360 / CA / NCI NIH HHS / United States
R01 HL046959 / HL / NHLBI NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
R01 HL034594 / HL / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
R01 HL068070 / HL / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 HL088416-03S1 / HL / NHLBI NIH HHS / United States
R01 HL026490 / HL / NHLBI NIH HHS / United States
HL-080467 / HL / NHLBI NIH HHS / United States
R01 HL080467 / HL / NHLBI NIH HHS / United States
1UL1RR025005 / RR / NCRR NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
R01 HL035464 / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
R01 CA040360 / CA / NCI NIH HHS / United States
HL-35464 / HL / NHLBI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
HL068070 / HL / NHLBI NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
R01 CA097193 / CA / NCI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R01 CA034944 / CA / NCI NIH HHS / United States
R01 HL091069 / HL / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
R01 HL105170 / HL / NHLBI NIH HHS / United States

© 2001 - 2020 CHS Coordinating Center University of Washington, Seattle, WA

Privacy | Terms