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Serum 25-hydroxyvitamin D and physical function in older adults: the Cardiovascular Health Study All Stars.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Serum 25-hydroxyvitamin D and physical function in older adults: the Cardiovascular Health Study All Stars. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Houston, DK, Tooze, JA, Davis, CC, Chaves, PHM, Hirsch, CH, Robbins, JA, Arnold, AM, Newman, AB, Kritchevsky, SB |
| Journal | J Am Geriatr Soc |
| Volume | 59 |
| Issue | 10 |
| Pagination | 1793-801 |
| Date Published | 2011 Oct |
| ISSN | 1532-5415 |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Female, Follow-Up Studies, Geriatric Assessment, Health Surveys, Humans, Male, Mobility Limitation, Muscle Strength, Physical Fitness, Proportional Hazards Models, Reference Values, United States, Vitamin D, Vitamin D Deficiency |
| Abstract | <p><b>OBJECTIVES: </b>To examine the association between 25-hydroxyvitamin D (25(OH)D) and physical function in adults of advanced age.</p><p><b>DESIGN: </b>Cross-sectional and longitudinal analysis of physical function over 3 years of follow-up in the Cardiovascular Health Study All Stars.</p><p><b>SETTING: </b>Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Allegheny County, Pennsylvania.</p><p><b>PARTICIPANTS: </b>Community-dwelling adults aged 77 to 100 (N = 988).</p><p><b>MEASUREMENTS: </b>Serum 25-hydroxyvitamin D 25(OH)D), Short Physical Performance Battery (SPPB), and grip and knee extensor strength assessed at baseline. Mobility disability (difficulty walking half a mile or up 10 steps) and activities of daily living (ADLs) disability were assessed at baseline and every 6 months over 3 years of follow-up.</p><p><b>RESULTS: </b>Almost one-third (30.8%) of participants were deficient in 25(OH)D (<20 ng/mL). SPPB scores were lower in those with deficient 25(OH)D (mean (standard error) 6.53 (0.24)) than in those with sufficient 25(OH)D (≥30 ng/mL) (7.15 (0.25)) after adjusting for sociodemographic characteristics, season, health behaviors, and chronic conditions (P = .006). Grip strength adjusted for body size was also lower in those with deficient 25(OH)D than in those with sufficient 25(OH)D (24.7 (0.6) kg vs 26.0 (0.6) kg, P = .02). Participants with deficient 25(OH)D were more likely to have prevalent mobility (OR = 1.44, 95% confidence interval (CI)) = 0.96-2.14) and ADL disability (OR = 1.51, 95% CI = 1.01-2.25) at baseline than those with sufficient 25(OH)D. Furthermore, participants with deficient 25(OH)D were at greater risk of incident mobility disability over 3 years of follow-up (hazard ratio = 1.56, 95% CI = 1.06-2.30).</p><p><b>CONCLUSION: </b>Vitamin D deficiency was common and was associated with poorer physical performance, lower muscle strength, and prevalent mobility and ADL disability in community-dwelling older adults. Moreover, vitamin D deficiency predicted incident mobility disability.</p> |
| DOI | 10.1111/j.1532-5415.2011.03601.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 22091492 |
| PubMed Central ID | PMC3228270 |
| Grant List | K01 AG030506-01A2 / AG / NIA NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States UL1 TR000005 / TR / NCATS NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States R01 AG024827 / AG / NIA NIH HHS / United States N01-HC85086 / HC / NHLBI NIH HHS / United States N01-HC85079 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG20098 / AG / NIA NIH HHS / United States N01-HC85083 / HC / NHLBI NIH HHS / United States N01-HC75150 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States K01 AG030506 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC85082 / HC / NHLBI NIH HHS / United States N01-HC45133 / HC / NHLBI NIH HHS / United States R01 AG15928 / AG / NIA NIH HHS / United States N01-HC85081 / HC / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States R01 AG023629-01 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC85085 / HC / NHLBI NIH HHS / United States N01-HC85080 / HC / NHLBI NIH HHS / United States N01-HC85084 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01 HC15103 / HC / NHLBI NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC35129 / HC / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |