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Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Jenny, NS, French, B, Arnold, AM, Strotmeyer, ES, Cushman, M, Chaves, PHM, Ding, J, Fried, LP, Kritchevsky, SB, Rifkin, DE, Sarnak, MJ, Newman, AB |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 67 |
| Issue | 9 |
| Pagination | 970-6 |
| Date Published | 2012 Sep |
| ISSN | 1758-535X |
| Keywords | Aged, Aged, 80 and over, Aging, C-Reactive Protein, Cardiovascular Diseases, Cognition, Cohort Studies, Cross-Sectional Studies, Female, Humans, Inflammation, Inflammation Mediators, Interleukin-6, Longitudinal Studies, Male, Risk Factors, Vermont |
| Abstract | <p><b>BACKGROUND: </b>Associations of inflammation with age-related pathologies are documented; however, it is not understood how changes in inflammation over time impact healthy aging.</p><p><b>METHODS: </b>We examined associations of long-term change in C-reactive protein (CRP) and interleukin-6 (IL-6) with concurrent onset of physical and cognitive impairment, subsequent cardiovascular disease (CVD), and mortality in 1,051 participants in the Cardiovascular Health Study All Stars Study. Biomarkers were measured in 1996-1997 and 2005-2006.</p><p><b>RESULTS: </b>In 2005-2006, median age was 84.9 years, 63% were women and 17% non-white; 21% had at least a doubling in CRP over time and 23% had at least a doubling in IL-6. Adjusting for demographics, CVD risk factors, and 1996-1997 CRP level, each doubling in CRP change over 9 years was associated with higher risk of physical or cognitive impairment (odds ratio 1.29; 95% confidence interval 1.15, 1.45). Results were similar for IL-6 (1.45; 1.20, 1.76). A doubling in IL-6 change over time, but not CRP, was associated with incident CVD events; hazard ratio (95% confidence interval) 1.34 (1.03, 1.75). Doubling in change in each biomarker was individually associated with mortality (CRP: 1.12 [1.03, 1.22]; IL-6 1.39 [1.16, 1.65]). In models containing both change and 2005-2006 level, only level was associated with CVD events and mortality.</p><p><b>CONCLUSIONS: </b>Although increases in inflammation markers over 9 years were associated with higher concurrent risk of functional impairment and subsequent CVD events and mortality, final levels of each biomarker appeared to be more important in determining risk of subsequent events than change over time.</p> |
| DOI | 10.1093/gerona/glr261 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 22367431 |
| PubMed Central ID | PMC3436091 |
| Grant List | N01-HC-85085 / HC / NHLBI NIH HHS / United States AG-027002 / AG / NIA NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States AG-15928 / AG / NIA NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |