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The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | de Hollander, EL, Bemelmans, WJe, Boshuizen, HC, Friedrich, N, Wallaschofski, H, Guallar-Castillón, P, Walter, S, Zillikens, CM, Rosengren, A, Lissner, L, Bassett, JK, Giles, GG, Orsini, N, Heim, N, Visser, M, de Groot, LCpgm |
| Corporate/Institutional Authors | WC elderly collaborators, |
| Journal | Int J Epidemiol |
| Volume | 41 |
| Issue | 3 |
| Pagination | 805-17 |
| Date Published | 2012 Jun |
| ISSN | 1464-3685 |
| Keywords | Aged, Body Mass Index, Body Weight, Cardiovascular Diseases, Female, Humans, Male, Mortality, Neoplasms, Overweight, Respiratory Tract Diseases, Risk Assessment, Waist Circumference |
| Abstract | <p><b>BACKGROUND: </b>For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.</p><p><b>METHODS: </b>Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC-BMI categories and continuous WC (including WC and WC(2)) were calculated by the investigators and pooled by means of random-effects models.</p><p><b>RESULTS: </b>During a 5-year-follow-up of 32 678 men and 25 931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ≥102 cm, women: ≥88 cm) was associated with increased all-cause mortality RRs for those in the 'healthy' weight {1.7 [95% confidence interval (CI): 1.2-2.2], 1.7 (95% CI: 1.3-2.3)}, overweight [1.1(95% CI: 1.0-1.3), 1.4 (95%: 1.1-1.7)] and obese [1.1 (95% CI: 1.0-1.3), 1.6 (95% CI: 1.3-1.9)] BMI category compared with the 'healthy' weight (20-24.9 kg/m(2)) and a small WC (<94 cm, men; <80 cm, women) category. Underweight was associated with highest all-cause mortality RRs in men [2.2 (95% CI: 1.8-2.8)] and women [2.3 (95% CI: 1.8-3.1]. We found a J-shaped association for continuous WC with all-cause, cardiovascular (CVD) and cancer, and a U-shaped association with respiratory disease mortality (P < 0.05). An all-cause (CVD) mortality RR of 2.0 was associated with a WC of 132 cm (123 cm) in men and 116 cm (105 cm) in women.</p><p><b>CONCLUSIONS: </b>Our results showed increased mortality risks for elderly people with an increased WC-even across BMI categories- and for those who were classified as 'underweight' using BMI. The results provide a solid basis for re-evaluation of WC cut-points in ageing populations.</p> |
| DOI | 10.1093/ije/dys008 |
| Alternate Journal | Int J Epidemiol |
| PubMed ID | 22467292 |
| PubMed Central ID | PMC4492417 |
| Grant List | N01 HC085086 / HC / NHLBI NIH HHS / United States N01 HC085081 / HC / NHLBI NIH HHS / United States G19/35 / / Medical Research Council / United Kingdom U01 HL080295 / HL / NHLBI NIH HHS / United States G0100222 / / Medical Research Council / United Kingdom N01 HC085083 / HC / NHLBI NIH HHS / United States G8802774 / / Medical Research Council / United Kingdom G0902037 / / Medical Research Council / United Kingdom N01 HC085082 / HC / NHLBI NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States RG/07/008/23674 / / British Heart Foundation / United Kingdom |