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Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Meta-analysis identifies six new susceptibility loci for atrial fibrillation. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Ellinor, PT, Lunetta, KL, Albert, CM, Glazer, NL, Ritchie, MD, Smith, AV, Arking, DE, Müller-Nurasyid, M, Krijthe, BP, Lubitz, SA, Bis, JC, Chung, MK, Dörr, M, Ozaki, K, Roberts, JD, J Smith, G, Pfeufer, A, Sinner, MF, Lohman, K, Ding, J, Smith, NL, Smith, JD, Rienstra, M, Rice, KM, Van Wagoner, DR, Magnani, JW, Wakili, R, Clauss, S, Rotter, JI, Steinbeck, G, Launer, LJ, Davies, RW, Borkovich, M, Harris, TB, Lin, H, Völker, U, Völzke, H, Milan, DJ, Hofman, A, Boerwinkle, E, Chen, LY, Soliman, EZ, Voight, BF, Li, G, Chakravarti, A, Kubo, M, Tedrow, UB, Rose, LM, Ridker, PM, Conen, D, Tsunoda, T, Furukawa, T, Sotoodehnia, N, Xu, S, Kamatani, N, Levy, D, Nakamura, Y, Parvez, B, Mahida, S, Furie, KL, Rosand, J, Muhammad, R, Psaty, BM, Meitinger, T, Perz, S, Wichmann, H-E, Witteman, JCM, Kao, LWH, Kathiresan, S, Roden, DM, Uitterlinden, AG, Rivadeneira, F, McKnight, B, Sjögren, M, Newman, AB, Liu, Y, Gollob, MH, Melander, O, Tanaka, T, Stricker, BHCh, Felix, SB, Alonso, A, Darbar, D, Barnard, J, Chasman, DI, Heckbert, SR, Benjamin, EJ, Gudnason, V, Kääb, S |
| Journal | Nat Genet |
| Volume | 44 |
| Issue | 6 |
| Pagination | 670-5 |
| Date Published | 2012 Apr 29 |
| ISSN | 1546-1718 |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Asian Continental Ancestry Group, Atrial Fibrillation, Child, Child, Preschool, European Continental Ancestry Group, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Infant, Newborn, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult |
| Abstract | <p>Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.</p> |
| DOI | 10.1038/ng.2261 |
| Alternate Journal | Nat. Genet. |
| PubMed ID | 22544366 |
| PubMed Central ID | PMC3366038 |
| Grant List | R21 DA027021 / DA / NIDA NIH HHS / United States K24 HL105780 / HL / NHLBI NIH HHS / United States R01 HL092217 / HL / NHLBI NIH HHS / United States R01 HL104156 / HL / NHLBI NIH HHS / United States U19 HL065962 / HL / NHLBI NIH HHS / United States U19 HL065962-12 / HL / NHLBI NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States R01 HL090620 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States L30 HL097675 / HL / NHLBI NIH HHS / United States R01 HL092217-04 / HL / NHLBI NIH HHS / United States R21 HL106092 / HL / NHLBI NIH HHS / United States |