You are here
Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults.
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Djoussé, L, Khawaja, O, Bartz, TM, Biggs, ML, Ix, JH, Zieman, SJ, Kizer, JR, Tracy, RP, Siscovick, DS, Mukamal, KJ |
| Journal | Diabetes Care |
| Volume | 35 |
| Issue | 8 |
| Pagination | 1701-7 |
| Date Published | 2012 Aug |
| ISSN | 1935-5548 |
| Keywords | Aged, Aged, 80 and over, Blood Glucose, Body Mass Index, Diabetes Mellitus, Fatty Acid-Binding Proteins, Fatty Acids, Nonesterified, Female, Humans, Male, Prospective Studies |
| Abstract | <p><b>OBJECTIVE: </b>To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults.</p><p><b>RESEARCH DESIGN AND METHODS: </b>We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993.</p><p><b>RESULTS: </b>Mean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10-1.65) for women and 1.45 (1.13-1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m(2) (HR per SD: 1.78 [95% CI 1.13-2.81]). There was a modest and nonsignificant association of NEFA with diabetes (P(trend) = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68 (95% CI 1.12-2.53), and 1.63 (1.07-2.50) across consecutive tertiles of NEFA (P(trend) = 0.03).</p><p><b>CONCLUSIONS: </b>Plasma FABP4 was positively associated with incident diabetes in older adults, and such association was statistically significant in lean men only. A significant positive association between plasma NEFA and incident diabetes was observed during the first 5 years of follow-up.</p> |
| DOI | 10.2337/dc11-1690 |
| Alternate Journal | Diabetes Care |
| PubMed ID | 22584136 |
| PubMed Central ID | PMC3402261 |
| Grant List | R01-AG20098 / AG / NIA NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States R01 HL075366 / HL / NHLBI NIH HHS / United States R01-AG027058 / AG / NIA NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States R01 HL085710 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01-HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R01-HL085710-01 / HL / NHLBI NIH HHS / United States P30-AG-024827 / AG / NIA NIH HHS / United States R01HL094555 / HL / NHLBI NIH HHS / United States R01-HL075366 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 HL094555 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01-AG15928 / AG / NIA NIH HHS / United States N01-HC-55222 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States |