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Association of weight status with mortality in adults with incident diabetes.

TitleAssociation of weight status with mortality in adults with incident diabetes.
Publication TypeJournal Article
Year of Publication2012
AuthorsCarnethon, MR, De Chavez, PJohn D, Biggs, ML, Lewis, CE, Pankow, JS, Bertoni, AG, Golden, SH, Liu, K, Mukamal, KJ, Campbell-Jenkins, B, Dyer, AR
JournalJAMA
Volume308
Issue6
Pagination581-90
Date Published2012 Aug 08
ISSN1538-3598
KeywordsAdult, Aged, Aged, 80 and over, Body Mass Index, Body Weight, Cardiovascular Diseases, Cause of Death, Diabetes Mellitus, Type 2, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Overweight, United States
Abstract<p><b>CONTEXT: </b>Type 2 diabetes in normal-weight adults (body mass index [BMI] <25) is a representation of the metabolically obese normal-weight phenotype with unknown mortality consequences.</p><p><b>OBJECTIVE: </b>To test the association of weight status with mortality in adults with new-onset diabetes in order to minimize the influence of diabetes duration and voluntary weight loss on mortality.</p><p><b>DESIGN, SETTING, AND PARTICIPANTS: </b>Pooled analysis of 5 longitudinal cohort studies: Atherosclerosis Risk in Communities study, 1990-2006; Cardiovascular Health Study, 1992-2008; Coronary Artery Risk Development in Young Adults, 1987-2011; Framingham Offspring Study, 1979-2007; and Multi-Ethnic Study of Atherosclerosis, 2002-2011. A total of 2625 participants with incident diabetes contributed 27,125 person-years of follow-up. Included were men and women (age >40 years) who developed incident diabetes based on fasting glucose 126 mg/dL or greater or newly initiated diabetes medication and who had concurrent measurements of BMI. Participants were classified as normal weight if their BMI was 18.5 to 24.99 or overweight/obese if BMI was 25 or greater.</p><p><b>MAIN OUTCOME MEASURES: </b>Total, cardiovascular, and noncardiovascular mortality.</p><p><b>RESULTS: </b>The proportion of adults who were normal weight at the time of incident diabetes ranged from 9% to 21% (overall 12%). During follow-up, 449 participants died: 178 from cardiovascular causes and 253 from noncardiovascular causes (18 were not classified). The rates of total, cardiovascular, and noncardiovascular mortality were higher in normal-weight participants (284.8, 99.8, and 198.1 per 10,000 person-years, respectively) than in overweight/obese participants (152.1, 67.8, and 87.9 per 10,000 person-years, respectively). After adjustment for demographic characteristics and blood pressure, lipid levels, waist circumference, and smoking status, hazard ratios comparing normal-weight participants with overweight/obese participants for total, cardiovascular, and noncardiovascular mortality were 2.08 (95% CI, 1.52-2.85), 1.52 (95% CI, 0.89-2.58), and 2.32 (95% CI, 1.55-3.48), respectively.</p><p><b>CONCLUSION: </b>Adults who were normal weight at the time of incident diabetes had higher mortality than adults who are overweight or obese.</p>
DOI10.1001/jama.2012.9282
Alternate JournalJAMA
PubMed ID22871870
PubMed Central IDPMC3467944
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
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N01-HC-85081 / HC / NHLBI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
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N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
R56 AG020098 / AG / NIA NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
AG-20098 / AG / NIA NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
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N01HC95165 / HL / NHLBI NIH HHS / United States
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N01HC55016 / HL / NHLBI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
5 R01 HL078972 / HL / NHLBI NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
N01HC48050 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
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