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Carotid artery measures are strongly associated with left ventricular mass in older adults (a report from the Cardiovascular Health Study).
Tuesday,2012-11-06 12:26 America/Los_Angeles — eenright
| Title | Carotid artery measures are strongly associated with left ventricular mass in older adults (a report from the Cardiovascular Health Study). |
| Publication Type | Journal Article |
| Year of Publication | 1996 |
| Authors | Kronmal, RA, Smith, VE, O'Leary, DH, Polak, JF, Gardin, JM, Manolio, TA |
| Journal | Am J Cardiol |
| Volume | 77 |
| Issue | 8 |
| Pagination | 628-33 |
| Date Published | 1996 Mar 15 |
| ISSN | 0002-9149 |
| Keywords | Aged, Carotid Arteries, Cohort Studies, Female, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Male, Regression Analysis, Risk Factors, Ultrasonography |
| Abstract | <p>Associations of carotid artery diameter and intimal-medial thickness by ultrasound with echocardiographic left ventricular (LV) structure were examined in 3,409 participants in the Cardiovascular Health Study, a population-based study of risk factors for coronary heart disease and stroke in men and women aged > or = 65 years. At baseline, sector-guided M-mode echocardiography and B-mode ultrasound were used to evaluate the left ventricle and carotid arteries, respectively. Common carotid artery diameter and intimal-medial thickness were significantly related to LV mass in correlational analysis (r=0.40 and 0.20, respectively, p<0.01), and each was independently associated with LV mass after adjustment for age, gender, weight, systolic and diastolic blood pressure, antihypertensive medication use, prior coronary heart disease, electrocardiographic abnormalities, high-density lipoprotein, and factor VII. We speculate that changes in the arterial wall affect impedance to LV ejection leading to increases in LV mass. Further follow-up of this cohort is in progress and will help to determine whether such carotid artery measures could, by exacerbating LV hypertrophy, constitute another important risk factor for adverse cardiovascular outcomes.</p> |
| Alternate Journal | Am. J. Cardiol. |
| PubMed ID | 8610615 |
| Grant List | N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States |