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Correlates of thrombin markers in an elderly cohort free of clinical cardiovascular disease.

TitleCorrelates of thrombin markers in an elderly cohort free of clinical cardiovascular disease.
Publication TypeJournal Article
Year of Publication1996
AuthorsCushman, M, Psaty, BM, Macy, E, Bovill, EG, Cornell, ES, Kuller, LH, Tracy, RP
JournalArterioscler Thromb Vasc Biol
Volume16
Issue9
Pagination1163-9
Date Published1996 Sep
ISSN1079-5642
KeywordsAged, Biomarkers, Cardiovascular Diseases, Cohort Studies, Female, Hemostasis, Humans, Male, Risk Factors, Thrombin
Abstract<p>Studies suggest that thrombosis is important in the progression of atherosclerotic lesions. The biochemical markers prothrombin fragment 1-2 and fibrinopeptide A reflect in vivo thrombin generation and activity, respectively. As such, they are markers that might be associated with cardiovascular risk. From the Cardiovascular Health Study, a cohort study of 5201 persons over 65 years of age, 399 persons free of clinical cardiovascular disease (CVD) at the baseline examination were selected for study of specialized markers of hemostasis. We report the cross-sectional relationships of the thrombin markers to CVD risk factors and measures of subclinical CVD. The range of fragment 1-2 2 was 0.12 to 0.85 nmol/L. The range of fibrinopeptide A was 0.9 to 44.1 micrograms/L. High levels of fragment 1-2 and fibrinopeptide A were associated with age, with levels higher in women than men. Fragment 1-2 was associated with smoking; high levels of triglyceride, creatinine, and C-reactive protein; and low levels of glucose. Fibrinopeptide A was associated with high C-reactive protein and apolipoprotein(a) and lower ankle-brachial index. There were no significant associations of the thrombin markers with race, fibrinogen, alcohol consumption, diabetes, or most measures of subclinical CVD. Study findings support a hypothesis that there are physiological interrelationships between cardiac risk factors, hemostasis, inflammation, and progression of atherosclerosis.</p>
Alternate JournalArterioscler. Thromb. Vasc. Biol.
PubMed ID8792770
Grant ListN01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
T3207594 / / PHS HHS / United States