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Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study.

TitleFactor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study.
Publication TypeJournal Article
Year of Publication1998
AuthorsCushman, M, Rosendaal, FR, Psaty, BM, Cook, EF, Valliere, J, Kuller, LH, Tracy, RP
JournalThromb Haemost
Volume79
Issue5
Pagination912-5
Date Published1998 May
ISSN0340-6245
KeywordsAdult, Age Factors, Aged, Arteries, Factor V, Female, Humans, Male, Middle Aged, Mutation, Risk Factors, Thrombosis
Abstract<p>Coagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up, we studied 373 incident cases of myocardial infarction (MI), angina, stroke. or transient ischemic attack (TIA), and 482 controls. The odds ratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70): TIA, 1.33 (95% CI 0.5 to 3.55); any outcome, 0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is not a risk factor for future arterial thrombosis.</p>
Alternate JournalThromb. Haemost.
PubMed ID9609219
Grant ListN01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States