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Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study.
Tuesday,2012-11-06 12:27 America/Los_Angeles — eenright
| Title | Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: results from the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Cushman, M, Rosendaal, FR, Psaty, BM, Cook, EF, Valliere, J, Kuller, LH, Tracy, RP |
| Journal | Thromb Haemost |
| Volume | 79 |
| Issue | 5 |
| Pagination | 912-5 |
| Date Published | 1998 May |
| ISSN | 0340-6245 |
| Keywords | Adult, Age Factors, Aged, Arteries, Factor V, Female, Humans, Male, Middle Aged, Mutation, Risk Factors, Thrombosis |
| Abstract | <p>Coagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up, we studied 373 incident cases of myocardial infarction (MI), angina, stroke. or transient ischemic attack (TIA), and 482 controls. The odds ratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70): TIA, 1.33 (95% CI 0.5 to 3.55); any outcome, 0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is not a risk factor for future arterial thrombosis.</p> |
| Alternate Journal | Thromb. Haemost. |
| PubMed ID | 9609219 |
| Grant List | N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States |